Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
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Produtos da "Sinalização PI3K/Akt/mTOR"
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(R)-(-)-Rolipram
CAS:(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.Fórmula:C16H21NO3Pureza:99.6%Cor e Forma:SolidPeso molecular:275.34GDC0084
CAS:GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.Fórmula:C18H22N8O2Pureza:99.16% - 99.76%Cor e Forma:SolidPeso molecular:382.42G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Fórmula:C22H19F2NO3Pureza:97.30%Cor e Forma:SolidPeso molecular:383.39Ref: TM-T8742
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg374,00€100mg523,00€200mg710,00€1mL*10mM (DMSO)105,00€ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFórmula:C16H11N3O3Pureza:99.39%Cor e Forma:SolidPeso molecular:293.28Ref: TM-T7426
1mg58,00€5mg116,00€10mg183,00€25mg313,00€50mg449,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)111,00€Avitinib maleate
CAS:Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.Fórmula:C30H30FN7O6Pureza:98% - 99.74%Cor e Forma:SolidPeso molecular:603.61EGFR-IN-136
EGFR-IN-136 (compound 21v) is a potent inhibitor of EGFR, demonstrating IC50 values of 20.2 nM, 1.2 nM, 2.3 nM, and 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, and EGFRLR/TM/CS, respectively. It exhibits antiproliferative and antitumor activities and holds potential for research in non-small cell lung cancer (NSCLC).Fórmula:C30H36N7O4PPeso molecular:589.625DA-143
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.Cor e Forma:Odour SolidCNX-2006
CAS:CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.Fórmula:C26H27F4N7O2Pureza:98.85% - 99.16%Cor e Forma:SolidPeso molecular:545.53Tilatamig
Tilatamig is a humanized antibody of the Ig(G1-κ, G1-λ2) type targeting EGFR/MET.Cor e Forma:Odour LiquidMK-3903
CAS:MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).Fórmula:C27H19ClN2O3Pureza:98.54% - 98.63%Cor e Forma:SolidPeso molecular:454.9Ref: TM-T5187
1mg35,00€5mg80,00€10mg120,00€25mg188,00€50mg354,00€100mg588,00€200mg833,00€1mL*10mM (DMSO)88,00€AS-041164
CAS:AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.Fórmula:C11H7NO4SPureza:99.45%Cor e Forma:SolidPeso molecular:249.24Selective PI3Kδ Inhibitor 1
CAS:Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).Fórmula:C23H20FN7OPureza:97.96%Cor e Forma:SolidPeso molecular:429.45Anti-EGFR Monoclonal Antibody-AF647
Anti-EGFR Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF647 can be used in FACS.Pureza:> 95% as determined by SDS-PAGE.Cor e Forma:LiquidPeso molecular:150 kDaBrivanib
CAS:Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFórmula:C19H19FN4O3Pureza:98.87%Cor e Forma:SolidPeso molecular:370.38Ref: TM-T6036
1mg47,00€5mg88,00€10mg144,00€25mg259,00€50mg375,00€100mg560,00€200mg815,00€1mL*10mM (DMSO)97,00€NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Fórmula:C24H26N4O3Pureza:99.38%Cor e Forma:SolidPeso molecular:418.49Ref: TM-T16343
1mg85,00€5mg160,00€10mg250,00€25mg424,00€50mg562,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€Neptinib
CAS:Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.Fórmula:C22H23ClFN5O2Cor e Forma:SolidPeso molecular:443.90SHR-A1201
SHR-A1201 is an antibody-drug conjugate (ADC) targeting HER2. This compound is composed of a humanized anti-HER2 antibody, the linker SMCC, and the cytotoxic payload Mertansine, which is a microtubule inhibitor. SHR-A1201 is utilized in research for HER2-positive breast cancer.Fórmula:C50H63ClF3N5O12Cor e Forma:LiquidPeso molecular:1018.51EGFR-IN-84
EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 μM and is utilized for lungFórmula:C25H20N6O3S2Pureza:98%Cor e Forma:SolidPeso molecular:516.59MTX-241F
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families.Fórmula:C20H14ClFN6Pureza:98%Cor e Forma:SolidPeso molecular:392.82hAChE-IN-5
hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency withPureza:98%Cor e Forma:Odour Solid
