Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
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Produtos da "Sinalização PI3K/Akt/mTOR"
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mTOR inhibitor-3
CAS:mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.Fórmula:C25H30N8O2Pureza:98.29% - 99%Cor e Forma:SolidPeso molecular:474.56Ref: TM-T12123
1mg60,00€5mg127,00€10mg180,00€25mg306,00€50mg464,00€100mg655,00€500mg1.359,00€1mL*10mM (DMSO)135,00€Naquotinib mesylate
CAS:Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFórmula:C31H46N8O6SPureza:98%Cor e Forma:SolidPeso molecular:658.813F8
CAS:3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used inFórmula:C15H14N2O4Pureza:98.05% - 98.49%Cor e Forma:SolidPeso molecular:286.28ARRY-380 (analog )
CAS:ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.Fórmula:C29H27N7O4SPureza:98.22%Cor e Forma:SolidPeso molecular:569.63Ref: TM-T2518
1mg35,00€2mg49,00€5mg74,00€10mg110,00€25mg180,00€50mg266,00€100mgA consultar1mL*10mM (DMSO)96,00€PI3Kδ-IN-18
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].Pureza:98%Cor e Forma:Odour SolidUmbralisib hydrochloride
CAS:Umbralisib hydrochloride: PI3Kδ inhibitor; IC50=22.2 nM, EC50=24.3 nM; active vs CK1ε, EC50=6.0 μM.Fórmula:C31H25ClF3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:608.01Icotinib
CAS:Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Fórmula:C22H21N3O4Pureza:100%Cor e Forma:SolidPeso molecular:391.42Ref: TM-T6153
1mg48,00€2mg64,00€5mg96,00€10mg155,00€25mg283,00€50mg527,00€100mg712,00€1mL*10mM (DMSO)97,00€WH-4-025
CAS:WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.Fórmula:C39H38F3N7O5Pureza:99.41%Cor e Forma:SolidPeso molecular:741.76Ref: TM-T9219
1mg40,00€2mg52,00€5mg88,00€10mg137,00€25mg264,00€50mg419,00€100mg617,00€1mL*10mM (DMSO)87,00€GSK3-IN-9
CAS:GSK3-IN-9 (0713) is a selective inhibitor of glycogen synthase kinase 3 (GSK3). It holds potential for research into fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood epilepsy, intellectual disabilities, diabetes, acute myeloid leukemia (AML), autism, and mental disorders.Fórmula:C18H20N4OCor e Forma:SolidPeso molecular:308.378Cloperastine fendizoate
CAS:Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Fórmula:C40H38ClNO5Pureza:99.85%Cor e Forma:SolidPeso molecular:648.19Sapanisertib
CAS:Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Fórmula:C15H15N7OPureza:100% - 99.67%Cor e Forma:SolidPeso molecular:309.33Ref: TM-T1838
1mg40,00€2mg51,00€5mg85,00€10mg96,00€25mg160,00€50mg235,00€100mg350,00€500mg838,00€1mL*10mM (DMSO)88,00€GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Fórmula:C18H22N6O2SPureza:99.77%Cor e Forma:SolidPeso molecular:386.47Ref: TM-T22339
1mg85,00€2mg115,00€5mg188,00€10mg321,00€25mg509,00€50mg702,00€100mg932,00€200mg1.283,00€1mL*10mM (DMSO)205,00€AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Fórmula:C25H24ClNO9Pureza:98%Cor e Forma:SolidPeso molecular:517.91Avitinib
CAS:Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,Fórmula:C26H26FN7O2Pureza:100%Cor e Forma:SolidPeso molecular:487.53DMH-25
CAS:DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.Fórmula:C15H8Br3NO3Pureza:99.26%Cor e Forma:SolidPeso molecular:489.94Ref: TM-T8569
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)212,00€Dehydroglyasperin D
CAS:Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29Fórmula:C22H24O5Pureza:98%Cor e Forma:SolidPeso molecular:368.42EGFR-IN-130
EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.Fórmula:C27H25N3O6SCor e Forma:SolidPeso molecular:519.57EGFR/CSC-IN-1
CAS:EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potentialFórmula:C54H54Cl2FN7O7S2Pureza:98%Cor e Forma:SolidPeso molecular:1067.08AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Fórmula:C12H7N3O2SPureza:97% - 99.91%Cor e Forma:SolidPeso molecular:257.27EGFR-IN-138
EGFR-IN-138 (compound 19) is a potent inhibitor of EGFR, with IC50 values of 37, 2.6, and 1.9 nM for the wild-type, L858R, and T790M EGFR, respectively.Fórmula:C42H37N7O5Cor e Forma:SolidPeso molecular:719.79
