Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
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Produtos da "Sinalização PI3K/Akt/mTOR"
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MOMIPP
CAS:MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.Fórmula:C18H16N2O2Pureza:99.66%Cor e Forma:SolidPeso molecular:292.33Ref: TM-T33467
1mg114,00€5mg160,00€10mg250,00€25mg455,00€50mg628,00€100mg944,00€1mL*10mM (DMSO)245,00€SRX3207
CAS:SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.Fórmula:C29H29N7O3SPureza:99.85%Cor e Forma:SolidPeso molecular:555.65HER2-IN-21
CAS:HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.Fórmula:C20H18N4O3SCor e Forma:SolidPeso molecular:394.447GSK-3β inhibitor 20
CAS:GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.Fórmula:C22H21N5O2SCor e Forma:SolidPeso molecular:419.50SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Fórmula:C16H10ClN3O5Pureza:99.55%Cor e Forma:SolidPeso molecular:359.72CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Fórmula:C20H17Cl2N9O2Pureza:97.25% - 99.41%Cor e Forma:SolidPeso molecular:486.31GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFórmula:C14H13N3OSPureza:98.42%Cor e Forma:SolidPeso molecular:271.34AZD8186
CAS:AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).Fórmula:C24H25F2N3O4Pureza:99.89% - 99.91%Cor e Forma:SolidPeso molecular:457.47Ref: TM-T6773
2mg46,00€5mg66,00€10mg99,00€25mg168,00€50mg304,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)72,00€K 00546
CAS:K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Fórmula:C15H13F2N7O2S2Pureza:99.12%Cor e Forma:SolidPeso molecular:425.44GSK-3β inhibitor 2
CAS:GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50Fórmula:C14H14N4O3SPureza:95.69%Cor e Forma:SolidPeso molecular:318.35Duvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Fórmula:C22H18Cl2N6OPureza:99.76% - 99.87%Cor e Forma:SoildPeso molecular:453.32Ref: TM-T11129L
1mg313,00€5mg758,00€10mg1.035,00€25mg1.568,00€50mg2.118,00€100mg2.783,00€1mL*10mM (DMSO)945,00€WZ4003
CAS:WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.Fórmula:C25H29ClN6O3Pureza:100% - 99.65%Cor e Forma:SolidPeso molecular:496.99Ref: TM-T6291
5mg50,00€10mg77,00€25mg117,00€50mg170,00€100mg255,00€200mg378,00€500mg622,00€1mL*10mM (DMSO)52,00€Theliatinib
CAS:Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Fórmula:C25H26N6O2Pureza:99.67%Cor e Forma:SolidPeso molecular:442.51MK8722
CAS:MK8722 is an effective and systemic activator of pan-AMPK.Fórmula:C24H20ClN3O4Pureza:98.08% - 99.88%Cor e Forma:SolidPeso molecular:449.89Ref: TM-T16099
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg226,00€50mg419,00€100mg617,00€1mL*10mM (DMSO)87,00€Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFórmula:C14H11ClN6O3Pureza:99.25% - 99.41%Cor e Forma:SolidPeso molecular:346.73Safingol hydrochloride
CAS:Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.Fórmula:C18H40ClNO2Pureza:99.31% - 99.71%Cor e Forma:SoildPeso molecular:337.969Anti-EGFR Monoclonal Antibody
Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: HumanPureza:> 95% as determined by SDS-PAGE.Cor e Forma:LiquidPeso molecular:150 kDaEGFRVIII Protein, Human, Recombinant (His & Avi)
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Cor e Forma:Lyophilized PowderPeso molecular:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.YH32367
YH32367 (ABL105) is a bispecific antibody targeting HER2 and 4-1BB. It induces the secretion of IFN-γ, resulting in the death of tumor cells when co-cultured with hPBMC and HER2-expressing tumor cells. YH32367 demonstrates notable antitumor activity.Cor e Forma:Odour LiquidDMNB
CAS:DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.Fórmula:C9H9NO5Pureza:97.87%Cor e Forma:Yellow SolidPeso molecular:211.17
