Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
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Produtos da "Sinalização PI3K/Akt/mTOR"
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Sevabertinib
CAS:Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.Fórmula:C24H25ClN4O5Pureza:99.81%Cor e Forma:SolidPeso molecular:484.93EGFR-IN-122
CAS:EGFR-IN-122 (compound Yfq07) serves as a potent inhibitor of EGFR. It effectively inhibits the proliferation of PC-9GR and HCC827GR cells.Fórmula:C19H20N4O3Cor e Forma:SolidPeso molecular:352.39BIO-acetoxime
CAS:BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.Fórmula:C18H12BrN3O3Pureza:97.28%Cor e Forma:SolidPeso molecular:398.21Ref: TM-T6787
1mg35,00€2mg48,00€5mg70,00€10mg104,00€25mg187,00€50mg298,00€100mg464,00€1mL*10mM (DMSO)78,00€Allitinib
CAS:Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Fórmula:C24H18ClFN4O2Pureza:99.10% - 99.28%Cor e Forma:SolidPeso molecular:448.88Ref: TM-T14336
1mg52,00€5mg111,00€10mg175,00€25mg329,00€50mg494,00€100mg700,00€1mL*10mM (DMSO)135,00€Alflutinib mesylate
CAS:Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.Fórmula:C29H35F3N8O5SPureza:97.94% - 99.81%Cor e Forma:SolidPeso molecular:664.7PI3Kδ-IN-3
CAS:PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.Fórmula:C28H24N6O3Pureza:98.43%Cor e Forma:SolidPeso molecular:492.53EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cellFórmula:C20H21N7O2SPureza:98%Cor e Forma:SolidPeso molecular:423.49Becotatug
CAS:Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugatePureza:98%Cor e Forma:LiquidLapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Fórmula:C29H26ClFN4O4SPureza:99.00% - 99.81%Cor e Forma:PowderPeso molecular:581.06IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Fórmula:C25H25N7O2Pureza:99.08%Cor e Forma:SolidPeso molecular:455.51Ref: TM-T15592
1mg47,00€2mg64,00€5mg104,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)113,00€Mobocertinib
CAS:Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agentFórmula:C32H39N7O4Pureza:98.66% - 99.47%Cor e Forma:SolidPeso molecular:585.7Saracatinib
CAS:Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.Fórmula:C27H32ClN5O5Pureza:98% - 99.63%Cor e Forma:SolidPeso molecular:542.03N,N-Didesethyl Sunitinib
CAS:N,N-Didesethyl Sunitinib Hydrochloride is a potent AMPK inhibitor with IC50 of 393 nM and 141 nM for AMPKα1 and AMPK2,respectively.Fórmula:C18H19FN4O2Pureza:97.1%Cor e Forma:SoildPeso molecular:342.37Parsaclisib hydrochloride
CAS:Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.Fórmula:C20H23Cl2FN6O2Pureza:98%Cor e Forma:SolidPeso molecular:469.34GSK3-IN-4
CAS:GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.Fórmula:C18H20N4OPureza:97.1%Cor e Forma:SoildPeso molecular:308.38Ref: TM-T64366
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg472,00€100mg645,00€200mg868,00€1mL*10mM (DMSO)153,00€EGFR-IN-83
EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50Fórmula:C22H17F3N4OPureza:98%Cor e Forma:SolidPeso molecular:410.39O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Fórmula:C21H22ClFN4O3Pureza:97.17%Cor e Forma:SolidPeso molecular:432.88Ref: TM-T16369
1mg56,00€5mg111,00€10mg170,00€25mg343,00€50mg547,00€100mg783,00€1mL*10mM (DMSO)120,00€SJF 1521
CAS:SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.Fórmula:C57H61ClFN7O9SPureza:99.20%Cor e Forma:SolidPeso molecular:1074.65Befotertinib
CAS:Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.Fórmula:C29H32F3N7O2Pureza:99.40%Cor e Forma:SolidPeso molecular:567.61Ref: TM-T39275
1mg88,00€5mg187,00€10mg298,00€25mg525,00€50mg747,00€100mg1.026,00€1mL*10mM (DMSO)235,00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Fórmula:C24H18N2O3SPureza:99.34%Cor e Forma:SolidPeso molecular:414.48Ref: TM-T15789
5mg46,00€10mg74,00€25mg145,00€50mg245,00€100mg364,00€200mg532,00€1mL*10mM (DMSO)49,00€
