mTOR
Os inibidores de mTOR são compostos que inibem a atividade do Alvo da Rapamicina em Mamíferos (mTOR), um regulador central do crescimento celular, proliferação, metabolismo e sobrevivência. A via de sinalização mTOR é frequentemente alterada em casos de câncer e outras doenças, tornando o mTOR um alvo crítico para intervenções terapêuticas. Inibidores de mTOR são amplamente utilizados em pesquisas relacionadas ao câncer, envelhecimento e distúrbios metabólicos. Na CymitQuimica, oferecemos uma variedade de inibidores de mTOR para apoiar sua pesquisa em transdução de sinais, oncologia e desenvolvimento terapêutico.
Produtos da "mTOR"
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Torkinib
CAS:Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).Fórmula:C16H16N6OPureza:99.11%Cor e Forma:SolidPeso molecular:308.34Ref: TM-T2414
5mg57,00€10mg74,00€25mg96,00€50mg136,00€100mg227,00€200mg338,00€500mg560,00€1mL*10mM (DMSO)63,00€3BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Fórmula:C18H17NO5Pureza:96.00%Cor e Forma:SolidPeso molecular:327.33Ref: TM-T14033
2mg47,00€5mg69,00€10mg97,00€25mg208,00€50mg331,00€100mg520,00€200mg777,00€500mg1.188,00€1mL*10mM (DMSO)74,00€ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Fórmula:C16H17N5O2Pureza:99.13%Cor e Forma:SolidPeso molecular:311.34Ref: TM-T25399
1mg52,00€5mg111,00€10mg175,00€25mg316,00€50mg512,00€100mg747,00€1mL*10mM (DMSO)124,00€MKC-1
CAS:MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Fórmula:C22H16N4O4Pureza:98.38% - 99.46%Cor e Forma:SolidPeso molecular:400.39Ref: TM-T9831
1mg57,00€5mg125,00€10mg177,00€25mg309,00€50mg445,00€100mg622,00€500mgA consultar1mL*10mM (DMSO)134,00€KU-0063794
CAS:KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.Fórmula:C25H31N5O4Pureza:100% - 98.35%Cor e Forma:SolidPeso molecular:465.54PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:96.59% - 99.3%Cor e Forma:SolidPeso molecular:348.36VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Fórmula:C17H22N8OPureza:97.82% - 99.54%Cor e Forma:SolidPeso molecular:354.41DIM-C-pPhOH
CAS:CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.Fórmula:C23H18N2OPureza:98.61%Cor e Forma:SolidPeso molecular:338.4Ref: TM-T4400
2mg44,00€5mg65,00€10mg84,00€25mg153,00€50mg227,00€100mg376,00€200mg495,00€1mL*10mM (DMSO)59,00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Fórmula:C17H20F3N7O2Pureza:97.58% - 98.92%Cor e Forma:SolidPeso molecular:411.38PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Fórmula:C20H13ClF2N4O4SPureza:96.16%Cor e Forma:SolidPeso molecular:478.86Ref: TM-T12459
1mg58,00€5mg145,00€10mg226,00€25mg378,00€50mg540,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)153,00€Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Fórmula:C15H12O8Pureza:96.68% - 98.13%Cor e Forma:SolidPeso molecular:320.25WAY-600
CAS:WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).Fórmula:C28H30N8OPureza:99.63%Cor e Forma:SolidPeso molecular:494.59Ref: TM-T6730
1mg38,00€2mg64,00€5mg97,00€10mg140,00€25mg245,00€50mg363,00€100mg507,00€500mgA consultar1mL*10mM (DMSO)111,00€mTORC1-IN-1
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseasesPureza:98%Cor e Forma:Odour SolidmTOR inhibitor-12
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to centralFórmula:C19H24N6O2SPureza:98%Cor e Forma:SolidPeso molecular:400.5D-α-Hydroxyglutaric acid disodium
CAS:D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.Fórmula:C5H6Na2O5Pureza:98%Cor e Forma:SolidPeso molecular:192.08Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Fórmula:C35H28F3N5O2Pureza:98.3% - 99.38%Cor e Forma:SolidPeso molecular:607.62ElteN378
CAS:ElteN378: potently inhibits FKBP12 (Ki=0.5 nM), low weight, similar affinity to Rapamycin.Fórmula:C23H26N2O3Pureza:98.09%Cor e Forma:SolidPeso molecular:378.46Ref: TM-T9950
1mg170,00€5mg376,00€10mg557,00€25mg895,00€50mg1.216,00€100mg1.691,00€200mg2.262,00€1mL*10mM (DMSO)329,00€AZD 3147
CAS:AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).Fórmula:C24H31N5O4S2Pureza:98.34%Cor e Forma:SolidPeso molecular:517.66Ref: TM-T36200
1mg97,00€5mg210,00€10mg338,00€25mg582,00€50mg777,00€100mg1.074,00€1mL*10mM (DMSO)273,00€Zotarolimus
CAS:Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).Fórmula:C52H79N5O12Pureza:95% - ≥98%Cor e Forma:SolidPeso molecular:966.21Ref: TM-T6033
1mg66,00€2mg96,00€5mg144,00€10mg225,00€25mg393,00€50mg565,00€100mg818,00€1mL*10mM (DMSO)239,00€mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Fórmula:C23H21N7OPureza:98%Cor e Forma:SolidPeso molecular:411.46
