Açúcares e Nucleobases da Espinha Dorsal

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5,6-Diamino-1,3-dipropyluracil (DAU) is a synthetic drug that acts as an adenosine receptor antagonist. DAU binds to the adenosine receptors in the brain and inhibits the binding of adenosine, which may result in an anti-congestive effect. DAU has been found to be a potent inhibitor of the A2A adenosine receptor at nanomolar concentrations. This inhibition may be due to its ability to form covalent bonds with the receptor or its affinity for or blocking of agonist binding sites on the receptor. It also has been shown to have affinity for dopamine receptors, although it is not yet known if this activity contributes to its anti-congestive effects.

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1-Cyclohexyluracil is a hydrogen bond donor. It has a chromophore and absorbs in the ultraviolet region of the electromagnetic spectrum. 1-Cyclohexyluracil is thermodynamically stable and has a constant, which is dependent on the pressure and temperature. The molecular weight of 1-Cyclohexyluracil is 174.16 g/mol and it has a molecular formula C5H6N4O2. 1-Cyclohexyluracil can bifurcate into two products, one with water as an intermediate, or it can undergo repair mechanism to regenerate itself. Intermolecular hydrogen bonding occurs between water molecules that are adjacent to each other on opposite sides of the molecule, which stabilizes the molecule by reducing energy fluctuations.

Cy5.5 is a near-infrared fluorescent dye (Ex=673 nm, Em=707 nm) that can be used to label biomolecules such as peptides, proteins, and oligonucleotides.Cost-effective and quality-assured.

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9-(2-Hydroxyethyl)adenine is a synthetic adenine derivative that has been used in the study of the structural and functional theory of DNA. It is a residue that is found in both RNA and DNA. Adenine forms hydrogen bonds with thymine, guanine, cytosine and uracil. 9-(2-Hydroxyethyl)adenine can be used to analyze environmental pollution by measuring the amount of free hydroxyl radicals present in a sample. It reacts spontaneously with other molecules at constant rates, but its reaction time depends on the number of complex molecules it interacts with. 9-(2-Hydroxyethyl)adenine has been shown to have anticancer effects on carcinoma cells by inhibiting ribonucleotide reductase activity.

N2-Pivaloylguanine is a versatile building block that can be used in the synthesis of many complex compounds. It has been shown to be an excellent reagent for the synthesis of heterocyclic molecules, and is also used as a reactant in a number of chemical reactions. N2-Pivaloylguanine is a high quality, useful intermediate that can be used to make other compounds, such as pharmaceuticals and agrochemicals. It is also a useful scaffold for the synthesis of research chemicals.

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Cy7.5 (Cyanine 7.5) is an anthocyanin fluorescent dye that emits near infrared (NIR) fluorescence.

7-Deazaadenine is a pyrimidine compound that inhibits the enzyme kinase, which is involved in DNA synthesis. 7-Deazaadenine has significant cytotoxicity against cells and has been shown to inhibit the polymerase chain reaction (PCR). It can be used as an analytical tool for investigating enzymatic reactions by selectively inhibiting specific enzymes. 7-Deazaadenine binds to nitrogen atoms in DNA and inhibits the activity of proteases, which are enzymes that break down proteins. This drug also has pharmacokinetic properties such as oral absorption and distribution, metabolism, and elimination.

6-Azauracil is a heterocycle with the chemical formula C8H10N2O3. It is approved by the FDA to treat HIV infections and has been shown to have pharmacokinetic properties in humans. 6-Azauracil is structurally similar to uracil, which is found in RNA, but lacks the hydroxyl group on the para position of the heterocyclic ring. The synthesis of this drug was accomplished through acid complex formation with nucleotides and nitrous acid. The compound inhibits replication of retroviruses by competitive inhibition of primer binding. 6-Azauracil has also been shown to be toxic in rats, leading to congestive heart failure and death when administered at high doses. This drug may also act as an anti-inflammatory agent by inhibiting prostaglandin synthesis or platelet aggregation.

2'-(N-Methylanthraniloyl)guanosine 3',5'-cyclicmonophosphate sodium salt is a fluorescent analog of guanosine that has been synthesized to study the signal transduction pathway. It inhibits cyclic nucleotide phosphodiesterase, an enzyme that breaks down cyclic GMP, which is a second messenger involved in synaptic transmission. 2'-(N-Methylanthraniloyl)guanosine 3',5'-cyclicmonophosphate sodium salt has been shown to inhibit the enzymatic activity of cyclic nucleotide phosphodiesterase in vitro and in vivo. This compound also exhibits fluorescence properties and can be used for assays.

5(6)-ROX, a nucleic acid fluorescent label, serves as a reference dye in real-time polymerase chain reaction (PCR) applications.

3',3'-Difluoro-3'-Deoxythymidine is an anti-HIV drug that belongs to the group of nucleoside analogues. It is a synthetic nucleoside analogue that is structurally similar to thymidine. 3',3'-Difluoro-3'-Deoxythymidine has been shown to inhibit HIV replication in cell culture, and has shown a low incidence of resistance development. 3',3'-Difluoro-3'-Deoxythymidine inhibits HIV by competitively binding to viral reverse transcriptase, thereby blocking its activity and preventing the production of viral DNA. This drug also inhibits cellular RNA synthesis, which may be due to its inhibition of purine synthesis.

6-Mercaptopurine is an antigen binding molecule that is biocompatible with the human body. It binds to 6-mercaptopurine and inhibits the oxidation of proteins. The inhibition of protein oxidation has been shown to decrease disease activity in patients with inflammatory bowel disease. 6-Mercaptopurine also inhibits the production of inhibitor molecules, which are responsible for the development of cardiac effects such as arrhythmias and cardiomyopathy. 6-Mercaptopurine has inhibitory properties against polymerase chain reactions, which may be due to its ability to bind with protein thiols at high rates.

N4-Hydroxycytosine is an intramolecular hydrogen that inhibits the replication of viruses by inhibiting their DNA polymerase. It is a structural analogue of cytosine and can be found in both left- and right-handed forms, which are termed isomers. The chemical study of N4-hydroxycytosine has shown it to have inhibitory effects on human immunodeficiency virus and hepatitis C virus. 13C-NMR spectroscopy has been used to identify the chemical structure of N4-hydroxycytosine and its reactivity with other molecules. N4-Hydroxycytosine can be synthesized by the reaction between formaldehyde and 2,3,5,6-tetrafluorocytosine.

2-Thioxanthine is a hydrated form of xanthine, which is a purine base that occurs in all living cells. This compound has been shown to be able to inhibit the growth of resistant mutants and the formation of atherosclerotic lesions in mice. 2-Thioxanthine also inhibits the transfer reactions that are required for bacterial DNA synthesis. The stability of 2-thioxanthine can be increased by forming stable complexes with hydrochloric acid and by reducing the pH to less than 7. 2-Thioxanthine has been shown to have genotoxic effects on mouse liver cells and human fibroblasts, as well as pharmacological properties against cardiovascular disease.

8-Aminoguanine is an anti-cancer agent that is used to treat leukemia. It is a hydrophobic molecule with a redox potential of −0.20 V and has been shown to inhibit the enzyme ribonucleotide reductase in vitro and in vivo. 8-Aminoguanine inhibits the production of guanine nucleotides, which are necessary for DNA synthesis and cell division. This drug also has angiogenic properties, which may be due to its ability to stimulate the formation of new blood vessels by increasing nitric oxide synthase activity. 8-Aminoguanine has also been shown to improve congestive heart failure by reducing myocardial fibrosis and ventricular hypertrophy through activation of the glycosidic bond cleavage system.

5-Amino-6-azauracil is an isomeric amino acid derivative that inhibits the growth of gram-negative bacteria, such as Escherichia coli, Salmonella typhimurium and Klebsiella pneumonia. It has been shown to be effective against Shigella dysenteriae and coliforms. 5-Amino-6-azauracil inhibits the synthesis of adenosine by competitive inhibition with ATP. This compound also inhibits prophage induction in E. coli K12 and Shigella flexneri 2a.

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Cy3.5 diacid is commonly used in biomolecular labeling, fluorescence imaging and other fluorescence biological analysis.

Intermediate in the synthesis of alogliptin

6-Chlorothymine is a purine nucleoside that is structurally similar to the natural nucleosides adenosine and guanosine. It is found in many organisms and has been shown to have inhibitory properties against the transfer of uracil from one nucleotide to another. 6-Chlorothymine can also be used as an acceptor for the conversion of 6-aminopurines into their pyrimidine derivatives, which are important precursors for DNA synthesis. This chemical compound is found in chloroplasts, where it is used as a precursor for deoxyribonucleotides.

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5-(2-Fluorovinyl)-2'-Deoxyuridine is a hydrophobic analogue of acyclovir that has potent activity against herpes simplex virus type 1. It inhibits the synthesis of viral DNA, and thus prevents the formation of plaques in tissue culture. This drug also inhibits cell proliferation and viral production by l1210 cells as well as lung fibroblasts. 5-(2-Fluorovinyl)-2'-Deoxyuridine has shown inhibitory effects against uninfected cells, but not against cells infected with herpes simplex virus type 2.

Cy2 (CY2 Non-Sulfonated) is a cyanine dye with long wavelength, tunable absorption and emission, high extinction coefficient and good water solubility.

Erythro-9-(2-hydroxy-3-nonyl)adenine hydrochloride (EHA) is a molecule that has been shown to inhibit skin tumor formation in mice. It has also been shown to be effective against solid tumours and cancer stem cells in mice. EHA is an amino acid derivative that inhibits the growth of cancer cells by targeting the molecules involved in the formation of skin tumors. The mechanism of action involves the inhibition of protein synthesis and DNA replication, as well as the induction of apoptosis. EHA can be used for pharmaceutical preparations against skin cancer and other solid tumours.

6-Aminouracil is a hydroxylated form of uracil. It has inhibitory properties against protein synthesis in bacteria, acting as an inhibitor of the enzyme dihydroorotase. 6-Aminouracil has been shown to be effective against PC3 cells and has high resistance to hydrolysis by acid or alkali. The reaction mechanism for the conversion of uracil to 6-aminouracil is unclear; however, it may involve a nucleophilic attack on the hydroxyl group.

Applications (E)-5-(2-Carboxvinyl)uracil (cas# 57412-59-6) is a compound useful in organic synthesis.

6-Amino-3-methyluracil is a synthetic compound that is used as an impurity in the synthesis of alogliptin. It is also used as a catalyst for the manufacture of aminomethylbenzene, which is a target product. 6-Amino-3-methyluracil can be extracted by filtration and has been shown to be trackable in the rat urine. The synthesis method of 6-amino-3-methyluracil involves chloride and alkylation reactions. This product's spectrum includes peaks at m/z 187, 196, 231, 238, 315 and 334.

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9-Methylxanthine is a purine alkaloid that is structurally related to caffeine. It is used as a bronchodilator and to treat cardiac arrhythmias. 9-Methylxanthine has been shown to have an effect on the rate of DNA replication by binding to the enzyme xanthosine phosphorylase, which converts xanthosine monophosphate (XMP) to xanthosine diphosphate (XDP). The drug's effect on other nucleobases, such as adenosine monophosphate (AMP), cannot be ruled out. 9-Methylxanthine also has a strong affinity for macrochelates, which are compounds that contain chelating agents with a large number of ethylenediaminetetraacetic acid (EDTA) groups. This property is due to the high number of nitrogen atoms in the molecule and its ability to form hydrogen bonds between water molecules