Açúcares e Nucleobases da Espinha Dorsal

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5-Propargylamino-ddCTP is used to make cyanine dye-nucleotide for DNA labeling and sequencing.

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6-Amino-1-methyl-5-nitrosouracil is a neutral form of the molecule that has both protonated and unprotonated forms. It is a bidentate ligand that can bind to a metal ion. The nitrogen atom in the molecule is an important part of its structure, as it contains two nitro groups and one amino group. 6-Amino-1-methyl-5-nitrosouracil has been used in techniques such as spectroscopies and dinitroso analysis. The neutral form of the molecule can be converted into its ionic form by adding either chlorine or nitrate ions to it, which causes the nitrogen atoms to be more electronegative. This conversion changes the nature of the compound, making it more acidic. Dehydration also occurs when water molecules are removed from 6-amino 1 methyl 5 nitrosourea, which causes a change in shape and shifts its properties to

Isocytosine is a prodrug that has been synthesized with the intramolecular hydrogen on the nitrogen atoms, which makes it more chemically stable. Isocytosine is a reactive molecule, and can react with tautomers to form isocytosine derivatives. Isocytosine contains three hydrogen atoms that are transferable through reactions to other molecules. The chemical stability of isocytosine allows for its use in wastewater treatment. It also has metabolic effects, such as the inhibition of colorectal adenocarcinoma and metabolic disorders. Isocytosine can be used as a model system for studying transfer reactions and reaction mechanisms.

1,2-Dipalmitoylphosphatidylfluorouridine is a drug that has been shown to be effective at treating inflammatory diseases. It is an uronic acid and may have anti-inflammatory properties due to its ability to inhibit the release of proinflammatory cytokines. 1,2-Dipalmitoylphosphatidylfluorouridine is taken orally and it enters the blood stream through the intestinal tract. This drug can also be administered in liposomal form. The drug binds to lipid bilayers and is slowly released from the body, which contributes to its long half-life. Pharmacokinetic studies have shown that this drug has a high uptake in tissues such as liver, heart, lungs, spleen, kidneys and bone marrow.

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Applications 6-​Phenyl-​2-​thiouracil is a reagent used in the synthesis of antifungal agents. References Gullapelli, K. et al.: Int. J. Pharm. Biol. Sci., 4, 59 (2014);

1,3-Dipropyl-7-methylxanthine is a xanthine compound that is structurally related to caffeine. It has been shown to have an inhibitory effect on the production of reactive oxygen species and cytosolic calcium levels in primary cells, as well as a nonselective adenosine receptor antagonist activity. It has also been shown to antagonize the effects of adenosine receptors, p2 receptors, and p2y receptors. This drug is used for the treatment of basophilic leukemia.

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Applications 5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.

3',5'-O-Dipalmitoyl-5-Fluoro-2'-Deoxyuridine is a liposome binding drug that has been shown to inhibit the growth of tumour cells in vitro. It can be used as a monoclonal antibody, monolayer, or fluidity enhancer. 3',5'-O-Dipalmitoyl-5-Fluoro-2'-Deoxyuridine binds to the surface of endothelial cells and prevents the attachment of platelets to the vessel wall. This activity may be due to its anticoagulant properties. 3',5'-O-Dipalmitoyl-5-Fluoro-2'-Deoxyuridine is not active against the major strains of bacteria that cause sepsis, such as methicillin resistant Staphylococcus aureus (MRSA). However, it has shown potential for use as an antibiotic because it inhibits bacterial cell division

Sulfo-Cyanine 3 is an alternative dye primarily used for labeling peptides and oligos in replacing Cy3 that was originally developed by GE Healthcare.

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8-Azahypoxanthine is a hydroxyl analog of hypoxanthine. It contains a nitrogen atom in place of the oxygen atom on the 2-position. 8-Azahypoxanthine has been shown to be an effective inhibitor of purine biosynthesis in yeast cells and can be used as a replacement for xanthine during the synthesis of adenosine triphosphate (ATP) from uracil. 8-Azahypoxanthine was found to have good detection sensitivity, with an estimated detection limit of 0.2 µM. The optimum pH for this compound is 7.8, which is similar to that of wild type strain and tissue culture media. Mutants resistant to 8-azahypoxanthine were generated by exposure to high concentrations (>100 mM) for long periods (>2 days). Mutant strains showed no detectable enzyme activity against orotic acid or glycosidic bond formation with erythromycin

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