Açúcares e Nucleobases da Espinha Dorsal

Please enquire for more information about 9-(2’-O-Acetyl-5’-O-benzoyl-3’-O-methyl-beta-D-ribofuranosyl)-2,6-dichloropurine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Pyrimidine with the ability to form complexes with heavy metal ions. References Iltzsch, M., et al.: Biochem. Pharmacol., 48, 781 (1994),

2-Iodo-9H-purine is a synthetic molecule that is used for labeling dna duplexes. It binds to the ATP binding site on the enzyme and can be detected by magnetic resonance imaging. 2-Iodo-9H-purine has shown to be effective in synthesizing cross-coupling products, which are used in the synthesis of purines and polyhydroxylated compounds. The compound was also synthesized using a solid phase synthesis method and has shown to have antituberculosis activity.

Please enquire for more information about 6-Amino-1-benzyl-3-methyl-5-(N-formyl-N-methyl)uracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

8-Methylxanthine is a metabolite of caffeine and theophylline. It has been shown to be a pro-inflammatory cytokine that stimulates the production of other pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha (TNFα). 8-Methylxanthine is also a substrate for cytochrome P450 enzyme activity, which is responsible for metabolizing many drugs and other chemicals in the body. This compound has been detected in human liver and urine samples. 8-Methylxanthine has cytotoxic properties and may serve as an antioxidant. Mass spectrometric detection methods are used to identify this compound in biological fluids.

Please enquire for more information about N6-Isopentenyladenine-3-glucuronide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Lambda DNA is a double stranded linear DNA of 48,502 base pairs in length. It is isolated from bacteriophage Lambda. The Lambda Phage is a bacterial virus (bacteriophage), that infects the bacterial species E. coli. The phage is isolated from the heat inducible lysogen E. coli strain.

Stability Hygroscopic Applications Adenine Hemisulfate can be one of the factors that influence in vitro growth and shoot multiplication of pomegranate. It can be used in biological study along with varied levels of sucrose, light intensity, and MS medium hydrogen ion concentration where those factors can all significantly influence multiplication and growth of Punica granatum shoots. References Singh, P., & Patel, R., M.: Bioscan, 9, 1031-1035 (2014)

1-Allyl-3,7-dimethyl-8-sulfophenylxanthine sodium salt is a chemical compound that is a competitive antagonist at the adenosine A1 receptor. It has been shown to be proconvulsant in mice and antagonizes the effects of caffeine. This drug also has an effect on neurotransmitter receptors and neurotransmitters, such as adenosine, which may be due to its ability to inhibit the breakdown of adenosine by methylxanthines.

Sulfo-Cy5.5 Trifluoroacetate: a cyano dye for low-background, non-invasive near-infrared in vivo imaging.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]-beta-D-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Fluoro-9-benzylpurine is a stable and halogenated analog of purine. It is hydrolyzed by the enzyme in the body and converted to fluorodeoxyglucose, which is then used for labeling of cells. 2-Fluoro-9-benzylpurine has been used for positron emission tomography (PET) imaging studies as a radiolabeling agent and for diagnosis of malignant tumors. Its specific activity is high enough to allow it to be used in preparations with low concentrations of active ingredient. 2-Fluoro-9-benzylpurine's uptake has been shown to be influenced by chloride ions and glutathione levels in the blood, which can be beneficial when using it as a tracer.

2-Thiothymine is a nucleotide that can be synthesized by the polymerase chain reaction. It is used as a probe for determining the sequence of DNA duplexes. 2-Thiothymine binds to dna and forms hydrogen bonds with the nitrogen atoms in dna bases, which prevents them from being able to bind with other dna bases, thereby disrupting the binding of dna strands. This leads to chain reactions that result in high temperatures and could cause damage to the cells. 2-Thiothymine has been shown to be toxic to both bacteria and human cells. It was found to inhibit HIV infection by binding to viral RNA and preventing it from being translated into protein, leading to cell death.

2'-Deoxy-2'-Fluoroguanylyl-(3'-5')Uridine is a ribose analog that has been shown to inhibit catalytic activity. This compound binds to the active site of ribonucleotide reductase, which is an enzyme that catalyzes the reduction of ribonucleotides to deoxyribonucleotides. The 2'-deoxy-2'-fluoroguanylyl-(3'-5')uridine analogs have been shown to bind at different positions on the enzyme than the natural substrate and have been used as inhibitors in studies of ribonucleotide reductase. These compounds have also been shown to interact with other enzymes such as DNA polymerase and protein kinases, which are involved in signal transduction pathways.

Please enquire for more information about 4-(3-Hydroxypropylamino)-1,3-dimethyluracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

3,7-Dimethyl-1-propargylxanthine is a cyclase inhibitor that has been shown to have pharmacological effects. It has been shown to be effective in vivo models of Parkinson's disease and has reduced locomotor activity. This drug also inhibits the production of adenosine and dopamine, leading to neuronal death. The 3,7-dimethyl-1-propargylxanthine shows high selectivity for adenosine A3 receptors and is an antagonist at these receptors. It prevents mitochondrial membrane potential from decreasing, which may be due to inhibition of the production of reactive oxygen species by mitochondria. 3,7-Dimethyl-1-propargylxanthine also inhibits platelet aggregation by blocking the activation of phospholipase C and enhances platelet aggregation by inhibiting phosphodiesterase activity.

2',3'-Di-O-isopropylidene-5-hydroxymethyl uridine (DIOI) is a fine chemical that can be used as a versatile building block or an intermediate in the research of complex compounds. DIOI is also a useful reagent, which may be used as a starting material for the synthesis of other compounds. It has been shown to have high quality and is available at CAS No. 3816-77-1.

Please enquire for more information about 3’-Deoxy-3’-fluoro-5-methoxyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

2’-Deoxy-6-azauridine is a pyrimidine nucleoside that is structurally similar to thymidylate. It has been shown to have antibacterial activity and can be used as an analog for the treatment of tuberculosis. The molecular modeling of 2’-deoxy-6-azauridine shows that it binds to the active site of bacterial enzymes, such as DNA gyrase and thymidylate synthase, which are involved in the synthesis of DNA. This binding prevents the bacterial enzymes from synthesizing DNA and RNA, leading to cell death. 2′-Deoxy-6′-azauridine also inhibits bacterial growth by inhibiting ribonucleotide reductase, which reduces ribonucleotides into deoxyribonucleotides. This inhibition leads to a decrease in dNTPs and an increase in dNMPs, causing a depletion of nucleotides necessary for DNA synthesis and

Intermediate in the synthesis of tipiracil + trifluridine

Please enquire for more information about 6-Amino-1-methyl-5-(methylamino)uracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-[3-(tert-butoxycarbonyl)amino]propyl-beta-D-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Resorufin (NSC-12097) (NSC-12097) is a highly fluorescent pink dye.

AMCA-6-dUTP can be used for enzymatic labeling of DNA/cDNA [1] .

5-(2-Chloroethyl)-2'-fluoroarabinofuranosyluracil is an analog of acyclovir that has been shown to inhibit the growth of uninfected cells. It also has a significant inhibitory effect on simplex virus type 1 and herpes simplex virus type 2. 5-(2-Chloroethyl)-2'-fluoroarabinofuranosyluracil inhibits protein synthesis by inhibiting viral DNA polymerase and the production of ribonucleic acid (RNA). This agent can be used for the treatment of cutaneous or mucosal lesions caused by herpes simplex virus infection.

9-(2-Chloro-6-Fluorobenzyl)-6-Methylaminopurine (9-MP) is an anticoccidial drug that inhibits coccidiosis in birds. It has a wide range of effective dose, which can be administered orally as well as through feed or water. The drug is a purine derivative that is converted to hypoxanthine, xanthine, and uric acid. 9-(2-Chloro-6-Fluorobenzyl)-6-Methylaminopurine also has a role in the life cycle of the parasite by inhibiting gametogenesis. This drug is used as a remedy for tenella infections in poultry and for prevention of coccidiosis in chickens.

Applications 4-Amino-1,3-dimethyl-5-nitrosouracil is a useful building block for organic synthesis.

9-Benzyl-6-chloro-7-deazapurine is an aryl halide that has been used in biomolecular chemistry as an arylation reagent. It reacts with nucleophiles to form covalent bonds. This compound has been used in Suzuki reactions to synthesize heterocycles, such as indoles and benzodiazepines. 9-Benzyl-6-chloro-7-deazapurine is also a halide that can be produced by removing a hydrogen atom from the corresponding alcohol. The functional group of this compound is the phenyl group, which contains a benzene ring and two adjacent carbon atoms. This compound can be catalyzed by acids or bases.

Fluoroethylguanosine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which is necessary for the synthesis of DNA. It has been shown to be effective against murine leukemia and other types of cancer cells. Fluoroethylguanosine reacts with guanosine at its 2’-position in an intrastrand cross-link, thereby preventing DNA replication and transcription. This analog also has a high affinity for purines and can form intramolecular crosslinks with p-388 (a protein) as well as other purines such as adenine and hypoxanthine.

Please enquire for more information about N3-(2S)-[2-(tert-Butoxycarbonyl)amino-3-(tert-butoxycarbonyl)]propyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-tetrahydrofurfuryl-beta-D-arabinouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

N2-Phenoxyacetyl guanine is a labile nucleoside that can be synthesized by the aminoacylation of guanosine with phenoxyacetic acid. It has been shown to have an important role in oxidative DNA damage, which may lead to mutagenesis and cancer. N2-Phenoxyacetyl guanine is stereoselective and binds preferentially to the GGC sequence, and it is also aminopropylated at its 2′ position. This nucleoside is not ionizing but can be degraded by radiation or enzymes such as deaminases.

Please enquire for more information about 3’-Deoxy-3’-fluoro-6-thioguanosine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5,6-Diamino-1,3-diethyluracil hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Sulfo-Cyanine7: Enhanced Cy7 analog with 20% better quantum yield, increased photostability for NIR imaging.

7-Deaza-6-hydroxypurine is a skeleton of nucleosides that inhibits enzymes. It has been shown to inhibit the activity of hydrochloric acid, a tumor metastasis promoter. The constant for this drug was determined using molecular modeling and inhibition constants. 7-Deaza-6-hydroxypurine has anticancer activity and can be used for the treatment of cancer. This drug is used as a noncompetitive inhibitor in which it binds to two different sites on the enzyme. It has also been shown to bind to subunits, which are parts of a protein that make up its structure, in biological studies.br> 7-Deaza-6-hydroxypurine is an inhibitor that binds to two different sites on an enzyme. It has been shown to have anticancer activity and can be used for the treatment of cancer. This drug is used as a noncompetitive inhibitor in which it binds to two different sites on the enzyme. It

Please enquire for more information about 2,6-Diaminopurine hemisulfateHemihydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page

3'-Fluoro-2',3'-Dideoxy-5-Iodouridine (3'-FDU) is a nucleoside analog that inhibits the replication of HIV in vitro. 3'-FDU is an analog of uracil and binds to viral RNA, which prevents viral DNA synthesis by blocking the incorporation of nucleotides into the growing strand. The antiviral activity was found to be dose dependent. 3'-FDU showed inhibitory effects on the replication of murine sarcoma virus and guinea pig hepatoma virus in vitro. The effective dose for treatment of HIV infection was found to be 500 micrograms per kilogram body weight. 3'-FDU has also been shown to inhibit RNA synthesis and protein synthesis in human cells infected with murine leukemia virus or human T-cell leukemia virus type 1.

Applications 3-BENZYLADENINE (cas# 7280-81-1) is a useful research chemical.

Guanosine 5'-(gamma-fluorotriphosphate) is a nucleotide that is involved in the hydrolysis of ATP. The catalytic activity of GTPase is an important factor in the activation energy for hydrolysis, which can be determined by kinetic studies. When magnesium ions are added to the reaction solution, the GTPase becomes more active. Guanosine 5'-(gamma-fluorotriphosphate) has been shown to have a constant sedimentation coefficient, which may be due to its hydroxyl group and fluorine atom. This nucleotide has been shown to inhibit guanine nucleotide binding in vitro and this inhibition may be competitively based on postulated models.

5-Iodocytosine (5-IC) is an analog of cytosine that can be used as a precursor for the synthesis of thymine. 5-IC has been shown to cross-couple with DNA, which may contribute to its antiviral potency. 5-IC is also a potent inhibitor of dna replication and herpes simplex virus. The biochemical properties of 5-IC have been extensively studied, including its ability to react with hydrochloric acid to form the corresponding tautomers. The hydrolysis rate increases at higher pH values and decreases at lower pH values. Bioconjugate chemistry has been applied to synthesize a bioconjugated prodrug of 5-IC for cancer treatment.