Açúcares e Nucleobases da Espinha Dorsal

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N2,9-Diacetylguanine is a synthetic molecule that can be used to inhibit the replication of herpes simplex virus. It has been found to inhibit the growth of viruses in vitro by binding to the viral DNA and inhibiting viral RNA synthesis. N2,9-Diacetylguanine is also a substrate for acetylation and may undergo this reaction with acetyl coenzyme A to form N4,9-diacetylguanine. The acetylated form of guanine inhibits the virus by blocking its ability to replicate DNA. The potential mechanism for this drug's anti-viral activity includes inhibition of the enzyme ribonucleotide reductase, which converts ribonucleotides into deoxyribonucleotides.

8-Cyclopentyl-1,3-dimethylxanthine (CPT) is a xanthine derivative that binds to the adenosine receptor and inhibits the phosphodiesterase enzyme. CPT is used in vivo as a model for measuring locomotor activity, dopamine receptors, adenosine receptors, and glutamate receptors. The binding of CPT to these receptors can lead to bronchoconstriction by stimulating the release of vasoactive substances from airway cells and increasing the sensitivity of airway cells to bronchoconstrictor stimuli. This drug also has been shown to inhibit calcium ion influx into cytosol and increase intracellular levels of cAMP.

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Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(2S)-(2-amino-3-carbonyl)propyluridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 9-(3-Deoxy-3-fluoro-beta-D-ribofuranosyl)-2-chloro-6-(thiophen-3-yl)purine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Intermediate in the synthesis of alogliptin

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Please enquire for more information about 3’,5’-Bis-O-benzoyl-2’-deoxy-2’-fluoro-beta-D-arabino-6-azidouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Applications 6-Benzyl-2-thiouracil (cas# 6336-50-1) is a useful research chemical.

Applications 5,6-Diaminouracil sulfate is an intermediate in the synthesis of Paraxanthine (P192500) and Paraxanthine analogs. References Mueller, C.E., et al.: J. Med. Chem., 36, 3341 (1993),

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6-Methyluracil is an antimetabolite that inhibits protein synthesis and is therefore used in the treatment of infectious diseases. 6-Methyluracil has two hydroxyl groups, which are located in adjacent positions on the ring. The optimum concentration for this drug is 3-10 μM, which can be achieved with a malonic acid buffer solution at pH 7.4. 6-Methyluracil reacts with sodium succinate to form an acid complex, which may have antiinflammatory activity. 6-Methyluracil has been shown to inhibit prostaglandin synthesis and exhibits a reaction with radiation to produce photoproducts that can be detected by analytical chemistry.

6-Aza-2-thiothymine is a hydrophobic base that is used in the preparation of DNA sequencing samples. It can be incorporated into DNA by enzymatic reactions with picolinic acid, which results in an increase in the number of thiol groups on the DNA. The incorporation of 6-aza-2-thiothymine into DNA is detected by binding to malonic acid and subsequent detection by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The presence of 6-aza-2-thiothymine can also be detected using a photochemical reaction with hydroxyl radicals, resulting in a change in the fluorescence properties of oligosaccharides bound to the DNA. This compound has been shown to inhibit prostate cancer cells and may be useful as a treatment for this type of cancer.

1-(2-Hydroxyethoxy)methyl-5-methyluracil is a nitro-substituted uracil derivative that inhibits the replication of DNA by binding to nucleic acids and inhibiting the synthesis of RNA. It has been shown to have strong inhibitory effects on solid tumours in mice. 1-(2-Hydroxyethoxy)methyl-5-methyluracil is orally active and can be used as an anti-cancer agent with a low toxicity for mammals.

2'-Deoxy-3',5'-bis-O-(4-methoxyphenoxy carbonyl)-5-fluoro-3-(4-n-propoxybenzoyl)uridine is an analog of uridine. It is used for the treatment of hypercalciuria in pediatric patients, as well as for the treatment of cancer. 2'-Deoxy-3',5'-bis-O-(4-methoxyphenoxy carbonyl)-5-fluoro-3-(4-n-propoxybenzoyl)uridine enhances the immune response to tumor cells by increasing the number of monoclonal antibodies that can react with tumor cells. This drug also has anti-cancer effects, and has been shown to inhibit tumor growth in animal models. 2'-Deoxy -3',5'-bis -O-(4 -methoxyphenoxy carbonyl)-5 -fluoro -3-(4 -

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