Açúcares e Nucleobases da Espinha Dorsal

Uracil-4-acetic acid is a monocarboxylic acid that is synthesized in mammalian cells. It can also be obtained by hydrolysis of orotic acid, which was previously synthesized from uridine and phosphorolysis of sephadex g-100. Uracil-4-acetic acid is used to produce uridine through the action of an enzyme called uridine phosphorylase. This enzyme catalyzes the reaction between ATP and uracil, as well as the conversion of orotic acid to orotidine 5′-monophosphate decarboxylase. Uracil-4-acetic acid has been shown to inhibit the growth of toxoplasma, but it has not been determined whether this inhibition is due to its role in the synthesis of uridine or its toxic effects on the parasite.

N9-Benzyladenine is a drug that regulates the activity of adenosine receptors. It is an endogenous substance found in plants and animals, but can also be synthesized chemically. N9-Benzyladenine has been shown to inhibit protein synthesis by binding to cyclic nucleotide phosphodiesterases, resulting in the accumulation of cyclic AMP and activation of adenylate cyclase. This leads to an increase in intracellular cAMP levels that is mediated by Gs protein coupled receptors. N9-Benzyladenine has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit the release of tumor necrosis factor-α (TNF-α).

Cy7 cadaverine is commonly used in biomolecular labeling, fluorescence imaging and other fluorescence biological analysis.

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Applications N2-Acetyl-O6-diphenylcarbamoylguanine is a reactant in the synthesis of 1',2'-oxetane-nucleosides bearing 2'-C-Me substituents with anti-HCV activity. References Komsta, Z., et. al.: Tetrahedron Lett., 55, 6216 (2014)

LDS-751 is a stain of nucleic acid.

Applications 9-(2-Propenyl)adenine is an N-substituted purine used in the preparation of mesityl dihydroisoxazolyl homo-N-nucleosides. References Thalassitis, A. et al.: Bioorg. Med. Chem. Lett., 19, 6433 (2009); Chiacchio, U. et al.: Tetrahedron, 60, 441 (2004)

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Sulfo-Cyanine 3 is an alternative dye primarily used for labeling peptides and oligos in replacing Cy5 that was originally developed by GE Healthcare.

O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

5-Propargylamino-ddUTP: used in making cyanine dye conjugates for DNA labeling and sequencing.

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6-Amino-1,3-dimethyluracil is a synthetic compound that has been shown to have antiinflammatory activity. This drug was synthesized from recycled methylene biphenyls and quinoline derivatives. 6-Amino-1,3-dimethyluracil inhibits the synthesis of proteins in cells by inhibiting the production of amino acids such as methionine through an attack on the amino group of methionine. 6-Amino-1,3-dimethyluracil also has apoptotic activity, which may be due to its ability to inhibit protein synthesis and increase the levels of active methylene.

1-Methyl-7-nitroisatoic anhydride (1M7) is a reagent. It detects local nucleotide flexibility, for probing 2'-hydroxyl reactivity.

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Sulfo-Cyanine7 is an improved analog of Cy7 fluorophore with quantum yield improved by 22%, and higher photostability.

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6-Amino-4-methoxy-2-methylthiouracil is a heterocyclic compound that belongs to the group of pyrimidine derivatives. It is a dimer that contains two rings and six carbon atoms. The molecule can be classified as centrosymmetric, hydrogen bonded, and chain. 6-Amino-4-methoxy-2-methylthiouracil has been shown to react with dimethyl acetylenedicarboxylate in the presence of light to form chains. This reaction is reversible and can be used for the synthesis of other compounds.

5-Methyoxycarbonyl methyl uracil is a nucleoside that contains a ribose sugar and a 5-methyloxycarbonyl methyluracil base. It is classified as a ribonucleoside, which are the building blocks of RNA. 5-Methyoxycarbonyl methyl uracil has been used in research to explore the structural diversity of nucleic acids and their posttranscriptional modifications. It has also been studied for its potential use as an antiviral agent against HIV.

5-Fluorouracil-1-yl acetic acid is a cytostatic drug that belongs to the amide class of drugs. It is used to treat cancer and other diseases. When 5-fluorouracil is reacted with sodium hydroxide solution, it yields 5-fluoroacetic acid (5FA). The resulting 5FA reacts with dibutyltin oxide in the presence of hydrogen gas, yielding 5-fluoroacetic anhydride (5FAA) and dibutyltin oxide monofluoride. The reaction produces a fluorescence spectrometry that can be used as a marker for the detection of cancerous cells in tissue culture.