Açúcares e Nucleobases da Espinha Dorsal

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Temozolomide is an anticancer drug that is used in the treatment of malignant brain tumors. It is a prodrug which undergoes conversion to its active form 7-methylguanine by deamination and oxidation. Temozolomide inhibits viral replication by inhibiting the synthesis of nuclear DNA and blocking the progression of RNA polymerase. The reaction mechanism involves oxidative injury to DNA, leading to crosslinking and breakage with subsequent inhibition of polymerase chain reaction amplification. Temozolomide has been shown to have carcinogenic potential in laboratory animals. This drug has been shown to have biochemical properties that are similar to those found in other drugs such as cisplatin, vinblastine, and adriamycin, which also inhibit cellular growth through reactive oxygen species (ROS) production. Structural analysis has revealed that temozolomide binds tightly to nuclear DNA with a conformation that is similar to the natural substrate for DNA gyrase, top

Applications N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate is a metabolite of Purine. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission. References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

5-Methoxy-4-thiouridine is a polymerization inhibitor of polynucleotides. It has been shown to be an inducer of polynucleotide phosphorylase, which is involved in the synthesis of DNA and RNA. 5-Methoxy-4-thiouridine also has antiviral activity by inhibiting interferon production. This drug can also inhibit protein synthesis by preventing phosphorylation of enzymes such as phosphorylase and glycogen synthase kinase 3β. The molecular weight of this compound is about 368 daltons, and it has a molecular formula of C5H6N5S2.

2'-Deoxy-5-fluorouridine 5'-(dihydrogen phosphate) is a potential anti-cancer compound. It is a prodrug that undergoes enzymatic conversion to 5-fluorouracil, its active form. The mechanism of action of 2'-deoxy-5-fluorouridine 5'-(dihydrogen phosphate) is not fully understood but it has been shown to inhibit tumor growth in mice. This drug also inhibits thymidylate synthase, an enzyme that converts thymine into thymidylate in the DNA synthesis pathway. Inhibition of this enzyme leads to the accumulation of thymine and depletion of deoxythymidine monophosphate (dTMP), which are necessary for DNA replication.

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2,6-Dibromopurine is a purine that is found in caffeine. It is an analogue of adenosine and inhibits the growth of human cells lines by competitively inhibiting the incorporation of deoxyadenosine into ribonucleotides. The kinetic study showed that 2,6-dibromopurine has a higher affinity for the adenosine receptor than adenosine. The effect of 2,6-dibromopurine on cellular metabolism has been shown to be stereospecific as it can inhibit both deoxyadenosine kinase and adenylate kinase activities. This drug also inhibited hematopoietic cells in vitro, which may be due to its ability to inhibit ribonucleotide reductase activity.