Açúcares e Nucleobases da Espinha Dorsal

Nb-N-(benzhydryloxycarbonyl)cytosine)-1-acetic acid is a speciality chemical that is used as a reagent, building block, and scaffold for organic synthesis. This compound can be used in various reactions to produce complex compounds with high purity. Nb-N-(benzhydryloxycarbonyl)cytosine)-1-acetic acid is an excellent starting material for the production of fine chemicals, research chemicals, and versatile building blocks. It is also a useful intermediate for the production of pharmaceuticals and other useful compounds.

3-Benzyladenine is an alkylating agent that has been shown to inhibit the growth of certain bacteria. It has been used as a marker for epidemiological studies and in the production of monoclonal antibodies. 3-Benzyladenine binds to DNA by methylating the N7 position of guanine, which blocks DNA replication and transcription. 3-Benzyladenine also inhibits chloride transport in cells with a diet high in protein and prevents the growth of bacteria through hydrophobic interactions with cell membranes. The bactericidal activity of 3-benzyladenine can be increased by deuteration or base excision, which selectively destroys bacterial DNA.

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N9-Methyladenine is a purine derivative that has been shown to be an antagonist at the adenosine receptor. It can be synthesized by reacting N6-benzoyladenine with methanol, followed by treatment with aqueous sodium hydroxide and hydrogen peroxide. The molecule is planar, with a neutral pKa of 7.4. Proton and nitrogen NMR spectra were obtained for this compound, which showed it to have two hydrogen bonds and one intermolecular hydrogen bond. The proton resonances are observed at 2.97 ppm (H1) and 3.27 ppm (H2).

3'-Amino-2',3'-dideoxyuridine (3'ADU) is an nucleoside analog that inhibits the growth of tumor cells by blocking the enzymatic reaction required for DNA synthesis. 3'ADU has been shown to be effective in treating immunodeficiency, and has been shown to inhibit the proliferation of cervical cancer cells. 3'ADU also inhibits HIV-1 replication in cultured lymphocytes, but does not affect the viral load in a rat liver microsome assay. The 6-fluoro-3-indoxyl-beta-D-galactopyranoside is a potent antituberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis and is metabolized through a number of metabolic transformations including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction

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Sulfo-Cyanine5 is an analog of Cy7, a very popular fluorophore, therefore this reagent is compatible to a wide range of standard fluorescent instrumentation

6-Chloro-7-methylpurine is a nucleoside analogue that inhibits the multidrug resistance-associated protein (MRP) and the pumps that are responsible for drug efflux. It is useful in the treatment of multidrug resistant organisms, including bacteria, yeast, and protozoa. 6-Chloro-7-methylpurine has been shown to be effective against MRP1 and MRP2, which are important for maintaining drug levels in cells. This compound also inhibits the uptake of drugs by cells. The uptake of 6-chloropurine by humans may be due to its ability to react with thiolate groups on proteins or endogenous substances such as phospholipids or nucleotides. 6-Chloro-7-methylpurine has been shown to inhibit translation in human brain tissue.

Applications 5-Carboxy-2-thiouracil is a possible anti-tumor agent when part of a metal complex.