Açúcares e Nucleobases da Espinha Dorsal

6-Cyanopurine is an antiviral agent that is a structural analog of adenine. The compound has been shown to inhibit the growth of murine sarcoma virus and herpes simplex virus, while also inhibiting the synthesis of bacterial DNA. 6-Cyanopurine inhibits bacterial growth by binding to the enzyme aldehyde oxidase, which is required for the production of cellular energy in mitochondria. This binding prevents the formation of ATP, which is required for replication and transcription in bacteria. In addition, 6-Cyanopurine may also have antimicrobial activity against tuberculosis and other infections caused by intracellular bacteria. 6-Cyanopurine binds to phosphonates and imidazoles and inhibits their regulatory function on bacterial growth.

9-Ethylguanine is a protonated guanine derivative that has significant cytotoxicity. It is an analog of the natural nucleobase guanosine and is structurally similar to the group P2 purine base, hypoxanthine. 9-Ethylguanine specifically binds with nitrogen atoms in DNA, forming hydrogen bonds with adjacent bases. The compound has low potency and therefore must be administered at high doses for it to be effective. 9-Ethylguanine has been shown to have anticancer activity against cervical cancer cells in cell cultures, but no biological studies have been conducted on other cancer types.

Cy7-YNE is a fluorescence labeling agent (Ex=700-770 nm,Em=790 nm) used for labeling antibodies, proteins, and peptides.

5-O-Carboranyl-1-(2-Deoxy-2-Fluoro-beta-D-Arabinofuranosyl)Uracil is a cell culture reagent that can be used to study the physicochemical properties of HIV. It has been shown to inhibit human immunodeficiency virus (HIV) infection of both CD4+ and CD8+ T cells in the laboratory. This compound also inhibits herpes simplex virus type 1 (HSV1) replication, which may be due to its ability to act as a sensitizer and modify the viral protein capsid. 5-O-Carboranyl-1-(2-Deoxy-2-Fluoro-beta-D-Arabinofuranosyl)Uracil has been shown to have pharmaceutical properties that are beneficial in treating human gliomas and other cancers.

2-Thiouracil is a photochemical that reacts with DNA by intermolecular hydrogen bonding, leading to DNA strand breakage. The reaction mechanism of 2-thiouracil has been elucidated through in vitro assays, which showed that the drug binds to the major groove of DNA duplexes and causes cleavage in the region containing two nitrogen atoms.

Sulfo-Cy5.5 is a near-infrared fluorescent dye that can be used to label biomolecules such as peptides, proteins, and oligonucleotides [2].

6-Benzylamino-7-deazapurine is a drug that has been shown to be effective in the treatment of pancreatic cancer. It is a monomer that reacts with nucleophiles such as 6-mercaptopurine, which are present in the human lung. The reaction generates an exergonic molecule that can be used to generate ATP and regenerate NAD+ during irradiation. This process has been observed using kinetic studies on human colon adenocarcinoma cells. 6-Benzylamino-7-deazapurine can also react with triazole compounds to form a linker and increase the rate of polymerization. The optimization of this reaction time could lead to more efficient cancer treatments.

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3-(2-Tetrahydrofuryl)-5-fluorouracil (3HFTU) is a fluorinated analog of 5-fluorouracil, a drug used in the clinical treatment of cancer. 3HFTU is used as an adjuvant therapy to increase the uptake and inhibitory properties of 5-fluorouracil in tumor tissue. This compound has been shown to be effective in inhibiting the growth of tumors by reducing their size and spread. 3HFTU has also been shown to have inhibitory properties against DNA synthesis, RNA synthesis, and protein synthesis. The chemical ionization technique is used to measure the diameter of 3HFTU particles. 3HFTU samples are prepared for measurement by adding a solvent that dissolves all solids and then filtering away the solids. A clinical use for this product is to provide adjuvant therapy for patients with cancerous tumors, who are undergoing radiation therapy or

O,O'-Bis(trimethylsilyl)thymine is a synthetic nucleoside that is used in the synthesis of DNA and RNA. It is a chloride-free nucleoside that contains an organic solvent, which makes it suitable for use in vitro tests. O,O'-Bis(trimethylsilyl)thymine has been shown to cause immunodeficient mice to produce antibodies when injected with this drug. It also has conformational properties that are similar to natural thymine, making it useful for nucleotide syntheses. O,O'-Bis(trimethylsilyl)thymine can be desulfurized by the enzyme desulfoviridin, which can increase its uptake by cells.

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