Açúcares e Nucleobases da Espinha Dorsal

2’-Chloro-2’-deoxy-5-methyluridine is a prodrug that is converted to 5-fluoro-2'-deoxyuridine monophosphate (5FdUMP) in mammalian cells. This conversion is catalyzed by cytidine deaminase, which converts the 2' position of the sugar moiety to an amino group. In mammalian cells, this conversion occurs at a low rate and requires incubation. The 5FdUMP derivative is then phosphorylated by deoxycytidine kinase to form 5-fluorouracil, which inhibits DNA synthesis and replication. The cytosine residues in DNA are converted to uracil residues, resulting in misreading of the genetic code. This leads to cell death due to depletion of cellular energy stores and eventual DNA fragmentation. Radiation enhances the effect of 2'chloro-2'-deoxy-5-methyluridine as it increases cytosine

6-Amino-1,3-dipropyl-5-nitrosouracil is a xanthine derivative that exhibits selectivity for adenosine A1 receptors. It binds to the receptor with high affinity and blocks the binding of adenosine. The compound also has an affinity for other adenosine receptors, including A2 and A3. 6-Amino-1,3-dipropyl-5-nitrosouracil has been shown to block the respiratory depressant effects of caffeine and theophylline in rats and dogs. This drug may be useful in treating bronchial asthma or chronic obstructive pulmonary disease (COPD).

Applications Protected guanine References Tretyakova, N., et al.: Chem. Res. Toxicol., 20, 284 (2007), Rana, S., et al.: Bioorg. Med. Chem. Lett., 19, 670 (2009),

5-Pyrrolidinomethyluridine is a nucleic acid which is an analog of uridine. It can be used to inhibit the synthesis of RNA and DNA by binding reversibly to ribonucleotide reductase and deoxyribonucleotide reductase, respectively. 5-Pyrrolidinomethyluridine also inhibits the production of mitochondrial respiratory chain complex I, which reduces oxidative phosphorylation by inhibiting ATP production. This drug has been shown to have anti-inflammatory activities in mice due to its ability to inhibit prostaglandin synthesis.

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Stability Hygroscopic Applications 6-Azauridine is can be applied in antiviral studies.

CY5 triethylamine salt is a water-soluble dye, Excitation (nm):649, Emission (nm): 670.

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Phosphoribosyltransferase inhibitor; photocytotoxic

5-Methoxyuracil is a labile, colorless and crystalline compound that occurs spontaneously in the presence of oxygen. It has a chemical structure similar to thiourea, with one methyl group substituted for the amino group on the heterocycle. 5-Methoxyuracil is used as a precursor for synthesis of thymine and uracil. It also acts as an antioxidant, preventing reactive oxygen species from causing cellular damage. 5-Methoxyuracil can be used in regenerative medicine to increase the production of messenger RNA (mRNA) and ribosomal RNA (rRNA). This drug is used as a prebiotic agent and can be synthetically produced by dimethylation of uridine followed by ethyl formate oxidation.