Açúcares e Nucleobases da Espinha Dorsal

6-Methylaminouracil is a drug that is used to treat bacterial infections. It has been shown to inhibit the growth of staphylococcus by inhibiting the synthesis of nucleic acids and proteins, which are required for cell division. 6-Methylaminouracil also inhibits the UV irradiation of subtilis and causes a bathochromic shift in the absorption spectrum. The photodestruction of 6-methylaminouracil has been observed in experiments with viologen and catalytic effect.

5-Bromocytosine is a nucleoside analog that inhibits the replication of RNA and DNA viruses. It binds to the 5-hydroxymethylcytosine residue in the viral dna duplexes, forming an acid complex. The reaction products are then cleaved by cellular enzymes, which leads to termination of the viral genetic material. 5-Bromocytosine can also be converted into a tautomeric form (5-bromouracil) by electron transfer. The vibrational frequencies of this tautomer are different from those of thymine, so it has been used for vibrational spectroscopy studies as well as FTIR spectroscopy studies.

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5-Azauracil is a glycosylase that specifically hydrolyzes the N-glycosidic bond in uridine. It is a potential anticancer agent that inhibits the growth of cancer cells by targeting intracellular targets and inhibiting enzyme activities. 5-Azauracil binds to nitrogen atoms in the enzyme active site, causing an alteration in the hydrogen bonding network and resulting in inhibition of enzyme activity. The reaction mechanism involves the formation of orotic acid as a product. 5-Azauracil also has been shown to inhibit x-ray diffraction data, which may be due to its ability to bind to an enzyme's metal cofactors such as iron or copper.

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1-(2'-Tetrahydrothienyl)-5 Fluorouracil-1-'1'-Dioxide (THTF) is an anti-cancer drug that is structurally related to 5-fluorouracil. It has been shown to be more resistant to oxidation and can be used in the treatment of skin cancer, cancer, and lymphocytic leukemia. THTF has been shown to inhibit the activity of oxidases, which are enzymes involved in the production of reactive oxygen species (ROS). This can lead to cell death by preventing DNA repair and oxidation of lipids. THTF has been shown to be effective against l1210 murine leukemia cells, but not human leukemia cells. The difference in sensitivity may be due to a different number of primers for PCR amplification or differences between the strains of mice used.

5-Bis(2-chloroethyl)aminouracil is a molecule that can be used to treat metastatic colorectal cancer. It has been shown to induce antibody responses in mice and to inhibit the growth of mouse monoclonal antibodies. 5-Bis(2-chloroethyl)aminouracil is used in the preparation of pharmaceuticals, including an effective chemotherapy for metastatic colorectal cancer. It also induces aminouracil synthesis in the mouse and is toxic to k562 cells, which are leukemia cells from a patient with acute myelocytic leukemia. 5-Bis(2-chloroethyl)aminouracil has also been shown to have anti-inflammatory properties and can be used as an agent against infectious diseases such as erythromycin resistant staphylococcus aureus (MRSA).

3-Deazaadenine is a purine nucleoside. It has been found to inhibit the growth of herpes simplex virus and other DNA viruses. 3-Deazaadenine inhibits viral DNA replication by interfering with the hydroxylation of deoxyguanosine, which is required for viral DNA synthesis. 3-Deazaadenine also has an inhibitory effect on the activity of human target enzymes such as dna polymerases, topoisomerases, and helicases. In vivo studies have shown that 3-deazaadenine can be used to treat herpes simplex virus infections in mice and rats.

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Applications Tris(trimethylsilyl)guanine is an intermediate used in the synthesis of 9-(2-Hydroxyethyl)guanine (H942035), which is an impurity of the antiviral agent Acyclovir (A192400). 9-(2-Hydroxyethyl)guanine is a nucleoside phosphotransferase acceptor. References Kamimura, A. et al.: Agric. Biol. Chem., 37, 2037 (1973);