Açúcares e Nucleobases da Espinha Dorsal

6-Chloro-9-benzylpurine is a purine derivative that has been shown to possess potential as an antiinflammatory agent. This compound reacts in a short time, with high efficiency and few byproducts, and has the potential for use in pharmaceuticals. 6-Chloro-9-benzylpurine is a potent inhibitor of histamine release from mast cells, which may be due to its ability to inhibit the production of inflammatory cytokines. It has also been shown to reduce the number of T cells which have infiltrated the skin in an animal model with psoriasis. 6-Chloro-9-benzylpurine is an anion that can be synthesized using acrylonitrile and butyl acrylate, and it has been found in nature. The reaction mechanism of 6-chloro 9-benzylpurine involves nucleophilic attack on the c-h bond followed by elimination of chloride ion and

Applications Used in therapy of mouse leukemia L1210 in combinations with Nebularin and Nitrobenzylthioinosine 5’-monophosphate. References Anderson, C., et al.: Neurosci. Lett., 219, 191 (1996), Allay, J., et al.: Nat. Med., 4, 1136 (1998),

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6-Azathymine is a compound that belongs to the group of amides. It has shown bacterial strain specificity and can be used for the treatment of infections caused by Group P2 bacteria. 6-Azathymine inhibits the enzyme activity of toll-like receptor, which is responsible for immune response and inflammation. It also has been shown to inhibit photosynthetic activity in plants. This drug may also be useful for eye disorders, such as retinitis pigmentosa and macular degeneration. 6-Azathymine is activated by hydroxyl groups, which leads to its toxicity at high concentrations.

8-Methoxymethyl-1-methyl-3-(2-methylpropyl) xanthine (8MMX) is an intracellular calcium ion chelator that inhibits enzyme activity in the cyclic nucleotide phosphodiesterase enzyme family. 8MMX has been shown to be a potent inhibitor of both cyclic nucleotide phosphodiesterases and cyclic nucleotide phosphodiesterase isoenzymes. 8MMX has been shown to inhibit bladder contractility and improve bladder function in animal models. It also reduces the incidence of papillary muscle rupture, which can lead to heart failure, and improves ventricular function by increasing the rate of relaxation of the left ventricle. 8MMX is a potential treatment for pulmonary hypertension, which is caused by increased concentrations of intracellular calcium ions.

Applications Labelled Guanine (G836000). Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009), Manini, P., et al.: Toxicol. Lett., 190, 41 (2009), Gong, B., et al.: Biochem., 48, 11961 (2009), Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010),

6-ROX (6-Carboxy-X-rhodamine) is a fluorescent oligonucleotide marker and acts as an acceptor molecule coupled to 5-FAM as the donor in FRET imaging with

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3'-O-Benzyl-2'-Deoxy-5-Trifluoromethyluridine (BDBMU) is a pyrimidine derivative that can be used as an antiviral drug. It inhibits the synthesis of DNA and RNA by inhibiting viral polymerase. BDBMU is a prodrug of uracil, which is converted to the active compound in tissues. The benzoylation reaction produces a fluorine atom at C5, which increases its potency. This drug has been shown to have minimal toxicity in tumor cells and has been used for the treatment of leukemia and other cancers.