Moduladores GABA
Os moduladores de GABA são compostos que influenciam a função dos receptores de GABA (ácido gama-aminobutírico), os principais receptores inibitórios de neurotransmissores no sistema nervoso central. Estes moduladores podem aumentar ou inibir a atividade GABAérgica, afetando a excitabilidade neuronal e a transmissão sináptica. Os moduladores de GABA são cruciais no tratamento e estudo de vários distúrbios neurológicos e psiquiátricos, incluindo ansiedade, epilepsia e insônia. Na CymitQuimica, oferecemos uma ampla gama de moduladores de GABA para apoiar sua pesquisa em neurociência, farmacologia e neuroterapêutica.
Produtos da "Moduladores GABA"
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7-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:166.19900512695312Flubromazepam
CAS:Produto ControladoApplications Flubromazepam is a designer benzodiazepine drug structurally related to Phenazepam (P295300); a drug used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. Phenazepam (P295300) can also be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. References Moosmann, B., et al.: J. Mass Spectrom., 48, 1150 (2013); Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989); Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993); Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008)Fórmula:C15H10BrFN2OCor e Forma:WhitePeso molecular:333.164-Boc-2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:248.32600402832032,2’-(1,4-Piperazinediyl)bis-pyrimidine
CAS:Produto ControladoImpurity Buspirone EP Impurity G Applications 2,2’-(1,4-Piperazinediyl)bis-pyrimidine is an impurity of Buspirone (B689850), an non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist. References Quaglia, M.G., et al.: J. Pharma. Biomed. Anal., 13, 505 (1995);Fórmula:C12H14N6Cor e Forma:NeatPeso molecular:242.28Butalbital-d5
CAS:Produto ControladoApplications Labelled Butalbital (B690100). Controlled substance (depressant). Sedative, hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Inaba, T., et al.: Clin. Pharmacol. Ther., 18, 558 (1975), Fritch, D., et al.: J. Anal. Toxicol., 33, 569 (2009), Wille, S., et al.: Ther. Drug Monit., 31, 511 (2009),Fórmula:C112H5H11N2O3Cor e Forma:WhitePeso molecular:229.297-BROMO-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE HCL
CAS:Pureza:95.0%Peso molecular:263.55999755859375Secbutabarbital
CAS:Produto ControladoApplications Controlled substance (depressant). Sedative, hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Heller, D., et al.: J. Agric. Food Chem., 49, 4597 (2001), Ramirez, A., et al.: Anal. Chem., 79, 3155 (2007),Fórmula:C10H16N2O3Cor e Forma:WhitePeso molecular:212.256-Chloro-2-(chloromethyl)-4-phenyl-quinazoline
CAS:Produto ControladoApplications Chlordiazepoxide (C327050) derivative.Fórmula:C15H10Cl2N2OCor e Forma:NeatPeso molecular:305.1610H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-4-oxido-1-piperazinyl)-
CAS:Fórmula:C17H20N4OSPureza:97%Cor e Forma:SolidPeso molecular:328.4319Pentanenitrile (Valeronitrile)
CAS:Produto ControladoFórmula:C5H9NCor e Forma:NeatPeso molecular:83.135,10-Dihydro-2-methyl-4H-thieno[2,3-β][1,5]benzodiazepin-4-one (Olanzapine Impurity)
CAS:Fórmula:C12H10N2OSPureza:96%Cor e Forma:SolidPeso molecular:230.2856Ref: IN-DA00C31Z
Produto descontinuadoMethylphenobarbital-d3
CAS:Produto ControladoApplications Controlled substance (depressant). Anticonvulsant; sedative; hypnotic. References Price, W.C., et al.: J. Pharm. Pharmacol., 6, 522 (1954), Brochman-Hanssen, E., et al.: J. Pharm. Sci., 58, 370 (1969), Lackner, H., et al.: Arch. Toxikol., 26, 220 (1970),Fórmula:C13H11D3N2O3Cor e Forma:NeatPeso molecular:249.28Flubromazepam (7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) 1.0 mg/ml in Methanol
CAS:Produto ControladoFórmula:C15H10BrFN2O5-Methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
CAS:Produto ControladoFórmula:C11H10N2O3Cor e Forma:NeatPeso molecular:218.21Nitrazepam (100μg/ml in Acetonitrile)
CAS:Produto ControladoFórmula:C15H11N3O3Cor e Forma:ColourlessPeso molecular:281.27Zolpidem Phenyl-4-carboxylic Acid
CAS:Applications A major metabolite of Zolpidem. References Crestani, F., et al.: Br. J. Pharmacol., 131, 1251 (2000), Li, Q., et al.: Bioorg. Med. Chem. Lett., 12, 465 (2002), Goulle, J., et al.: Ther. Drug Monit., 26, 206 (2004), Ohkanda, J., et al.: J. Med. Chem., 47, 432 (2004), Blackaby, W., et al.: Bioorg. Med. Chem. Lett., 16, 1175 (2006),Fórmula:C19H19N3O3Cor e Forma:Off-White To Light BeigePeso molecular:337.37(2S)-2-(5-Fluoro-2,4-dinitroanilino)propanamide
CAS:Produto ControladoFórmula:C9H9FN4O5Cor e Forma:NeatPeso molecular:272.192-Hydroxypropyl 4-(2-Chlorophenyl)-6-nitro-quinazoline-2-carboxylate
Fórmula:C18H14ClN3O5Cor e Forma:Neat5-Allyl-6-imino-5-(1-methyl-2-pentynyl)hydrouracil
CAS:Produto ControladoFórmula:C13H17N3O2Cor e Forma:NeatPeso molecular:460.6067-Fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:194.1649932861328N-Desmethyl Clotiazepam
CAS:Produto ControladoApplications Clotiazepam (C587410) metabolite, with central nervous depressant and anxiolytic activity. References Ito, K. et al.: Biopharm. Drug. Dispos., 18, 293 (1997); Nakanishi, M. et al.: J. Med. Chem., 16, 214 (1973)Fórmula:C15H13ClN2OSCor e Forma:NeatPeso molecular:304.79Clotiazepam
CAS:Produto ControladoApplications A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance. References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);Fórmula:C16H15ClN2OSCor e Forma:Off-WhitePeso molecular:318.82Methylphenobarbital
CAS:Produto ControladoApplications Controlled substance (depressant). Anticonvulsant; sedative; hypnotic. References Price, W.C., et al.: J. Pharm. Pharmacol., 6, 522 (1954), Brochman-Hanssen, E., et al.: J. Pharm. Sci., 58, 370 (1969), Lackner, H., et al.: Arch. Toxikol., 26, 220 (1970),Fórmula:C13H14N2O3Cor e Forma:WhitePeso molecular:246.264-(2-Methylpropyl)piperidine-2,6-dione (3-Isobutylglutarimide)
CAS:Produto ControladoFórmula:C9H15NO2Cor e Forma:NeatPeso molecular:169.224-Boc-7-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:266.3160095214844N-Methyl Zonisamide
CAS:Produto ControladoApplications A methylated analog of Zonisamide (Z700000) with anticonvulsant activity. References Uno, H., et al.: J. Med. Chem., 22, 180 (1979)Fórmula:C9H10N2O3SCor e Forma:NeatPeso molecular:226.25Tizanidine Hydrochloride
CAS:Produto ControladoApplications An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). References Turski, L., et al.: Brain Res., 379, 367 (1986), Ono, H., et al.: Gen. Pharmacol., 17, 137 (1986), Hoogstraten, M.C., et al.: Acta Neurol. Scand., 77, 224 (1988)Fórmula:C9H8ClN5S·ClHCor e Forma:Light YellowPeso molecular:290.177-Bromo-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Pureza:95+%Peso molecular:269.0979919433594Butobarbital-d5
CAS:Produto ControladoApplications Labelled Butobarbital, a barbiturate derivative that is used as a hypnotic agent with sedative and anticonvulsant properties. Butobarbital is a Controlled Substance. References Sitsen, J.M.A. et al.: Pharmac. Week., 109, 1 (1974); Adams, R.G.: Psychopharmacologia, 40, 185 (1974);Fórmula:C10H11D5N2O3Cor e Forma:NeatPeso molecular:217.28N-Demethyl Olanzapine
CAS:Produto ControladoApplications A metabolite of Olanzapine.Fórmula:C16H18N4SCor e Forma:BrownPeso molecular:298.416-(8-Chloro-4,5-dihydro-1-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ylidene)-2,4-cyclohexadien-1-one
CAS:Produto ControladoFórmula:C18H14ClN3OCor e Forma:NeatPeso molecular:323.78Oxcarbazepine EP Impurity F
CAS:Produto ControladoFórmula:C16H12ClNO2Cor e Forma:NeatPeso molecular:286.00Nitrazepam (1.0 mg/mL in Acetonitrile)
CAS:Produto ControladoFórmula:C15H11N3O3Cor e Forma:ColourlessPeso molecular:281.274-Boc-8-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:266.3160095214844EMEDASTINE FUMARATE
CAS:Fórmula:C25H34N4O9Pureza:98%Cor e Forma:SolidPeso molecular:534.55885999999993-AMINO-1-METHYL-5-PHENYL-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:265.31600952148447-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione
CAS:Pureza:95.0%Peso molecular:208.192001342773442-[[(2-Amino-5-nitrophenyl)(2-chlorophenyl)methylene]amino]acetic Acid
Fórmula:C15H12ClN3O4Cor e Forma:Neat7-Bromo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:255.07099914550786-Amino-5-ethyl-5-(1-methylbutyl)-2,4(3H,5H)-pyrimidinedione
CAS:Produto ControladoApplications 6-Amino-5-ethyl-5-(1-methylbutyl)-2,4(3H,5H)-pyrimidinedione is an impurity of Pentobarbital (P276000), an sedative and hypnotic.Fórmula:C11H19N3O2Cor e Forma:WhitePeso molecular:225.298-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:166.199005126953124-Boc-7,8-Dimethoxy-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Pureza:97.0%Peso molecular:308.377990722656253-Amino-4-(2-chlorophenyl)-6-nitroquinolin-2(1H)-one
CAS:Fórmula:C15H10ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:315.7112Mesocarb
CAS:Produto ControladoApplications Mesocarb is a CNS stimulant that acts as a dopamine reuptake inhibitor. Mesocarb is a psychotropic drug. Mesocarb is used to counteract the sedative effects of benzodiazepine drugs. References Gainetdinov, R.R. et al.: Eur. J. Pharmacol., 340, 53 (1997); Kholodov, L.E. et al.: Khim.-Farmat. Zhur., 7, 50 (1973); Valueva, L.N. et al.: Zhur. Nevropatol. Psikh. S. S. Korsak., 82, 1212 (1982);Fórmula:C18H18N4O2Cor e Forma:NeatPeso molecular:322.36Bromazepam-d4
CAS:Produto ControladoApplications Controlled substance (depressant). Anxiolytic. Labelled Bromazepam. References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),Fórmula:C142H4H6BrN3OCor e Forma:NeatPeso molecular:320.18Olanzapine (1mg/ml in Acetonitrile)
CAS:Fórmula:C17H20N4SCor e Forma:Single SolutionPeso molecular:312.43Flumazenil Carboxylic Acid
CAS:Applications Flumazenil carboxylic acid is a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine. References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)Fórmula:C13H10FN3O3Cor e Forma:White To Off-WhitePeso molecular:275.24Clonazepam-d4 (1.0 mg/mL in Methanol)
CAS:Produto ControladoFórmula:C152H4H6ClN3O3Cor e Forma:Single SolutionPeso molecular:319.74Ketazolam
CAS:Produto ControladoStability Unstable in Solution Applications A psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance. References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);Fórmula:C20H17ClN2O3Cor e Forma:Off White CrystallinePeso molecular:368.81Ketazolam-13C,d3
CAS:Produto ControladoApplications A labelled psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance. References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);Fórmula:C1913CH14D3ClN2O3Cor e Forma:NeatPeso molecular:372.827-Chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-amine
CAS:Applications An impurity of Alprazolam (A575650). The major degradation product in Alprazolam tablets during their stability assay. References Nudelman, N., et al.: J. Pharm. Sci., 91, 1274 (2002), Marin, A., et al.: Anal. Chem., 77, 471 (2005),Fórmula:C17H13ClN4Cor e Forma:White To Off-WhitePeso molecular:308.76Tilivalline
CAS:Applications Tilivalline, is a metabolite from Klebsiella oxytoca. Tilivalline, is shown to be cytotoxin, and the key event causing Antibiotic-Associated Hemorrhagic Colitis. References Mori, Sh., et al.: Tetrahedron, 47, No.27, 5051 (1991); Nagasaka, T., et al.: Tetrahedron Lett., 14, 1871 (1989);Fórmula:C20H19N3O2Cor e Forma:Light BrownPeso molecular:333.38Pyrrolidin-2-one (2-Pyrrolidone)
CAS:Produto ControladoFórmula:C4H7NOCor e Forma:NeatPeso molecular:85.102,3,4,5-Tetrahydro-1H-1,4-benzodiazepine, 95%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C9H12N2Pureza:95%Cor e Forma:Yellow with orange to pale brown, Crystals or powder or crystalline powder or lumpy solidPeso molecular:148.217-Amino Clonazepam
CAS:Produto ControladoApplications The major metabolite of Clonazepam (C587080). References Clark, D., et al.: Drugs, 29, 342 (1985), Colmenero, J., et al.: Antimicrob. Agents Chemother., 38, 2798 (1994), Grant, D., et al.: Pharmacology, 61, 204 (2000), Negrusz, A., et al.: Anal. Bioanal. Chem., 376, 1198 (2003),Fórmula:C15H12ClN3OCor e Forma:YellowPeso molecular:285.73Cloxazolam
CAS:Produto ControladoApplications Cloxazolam is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Substance. References Oliveira-Silva, D. et al.: Biomed. Chrom., 23, 1266 (2009); Kamioka, T. et al.: Psychopharmacol., 52, 17 (1977); Fischer-Cornelssen, K.A. et al.: Arzneim.-Forsch., 31, 1757 (1981);Fórmula:C17H14Cl2N2O2Cor e Forma:NeatPeso molecular:349.21Nimetazepam-d3
CAS:Produto ControladoApplications Labelled Nimetazepam (N477800). Sedative, hypnotic. Controlled substance. References Inaba, et al.: Chem. Pharm. Bull., 19, 722 (1971), Sakai, S., et al.: Arzneim.-Forsch., 22, 534 (1972),Fórmula:C16H10D3N3O3Cor e Forma:NeatPeso molecular:298.318-Chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS:Produto ControladoFórmula:C17H12ClFN4Cor e Forma:NeatPeso molecular:326.765-(2-Bromophenyl)-7-fluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Flubromazepam Isomer)
CAS:Fórmula:C15H10BrFN2OPirenzepine, Dihydrochloride
CAS:Produto ControladoApplications An antiulcerative. Tricyclic gastric-acid inhibitor. References Eberlein, W., et al.: Arzneimittel-Forsch., 27, 356 (1977), Hellerr, G., et al.: Verh. Deut. Ges. Inn. Med., 84, 991 (1978), Carmine, A.A., et al.: Drugs, 30,85 (1985), El-Obeid, H.A., et al.: Anal. Profiles Drug Subs., 16, 445 (1987), Homon, C.A., et al.: Ther. Drug Monit., 9, 236 (1987),Fórmula:C19H21N5O2·2ClHCor e Forma:NeatPeso molecular:424.324-Amino-2-methyl-10H-thieno[2,3-b][1,5]-benzodiazapine, Hydrochloride
CAS:Produto ControladoImpurity Olanzapine Impurity 6 HCl Applications Intermediate in the preparation of Olanzapine (O253750). Olanzapine Impurity 6 HCl. References Calligaro, D., et al.: Bioorg. Med. Chem. Lett., 7, 25 (1997),Fórmula:C12H11N3S·ClHCor e Forma:NeatPeso molecular:265.76Sultiame 100 µg/mL in Acetonitrile
CAS:Fórmula:C10H14N2O4S2Cor e Forma:Single SolutionPeso molecular:290.362-Bromo-2'-(2-chlorobenzoyl)-4'-nitroacetanilide
CAS:Produto ControladoFórmula:C15H10BrClN2O4Cor e Forma:NeatPeso molecular:397.61N-Descarboxymethyl-N-carboxyethyl Lacosamide (Impurity)
CAS:Produto ControladoApplications N-Descarboxymethyl-N-carboxyethyl Lacosamide is an impurity of Lacosamide (L098500), an anticonvulsant drug that enhances sodium channel slow inactivation, and is used to treat patients with epilepsy. References Doty, P., et al.: Neurotherapeutics, 4, 145 (2007); Perucca, E., et al.: Nat. Rev. Drug Discov., 7, 973 (2008); Sake, J., et al.: CNS Drugs, 24, 1055 (2010)Fórmula:C14H20N2O3Cor e Forma:NeatPeso molecular:264.327-Amino Nimetazepam
CAS:Produto ControladoApplications A metabolite of Nimetazepam. Controlled substance. References Nishikawa, M., et al.: Forensic Sci. Int., 66, 149 (1994), Katagi, M., et al.: J. Anal. Toxicol., 24, 354 (2000),Fórmula:C16H15N3OCor e Forma:NeatPeso molecular:265.31Lixivaptan
CAS:Produto ControladoApplications Drug used in the treatment and prevention of cardiovascular diseases. References Lo, R., et al.: Curr. Clin. Pharmacol., 3, 156 (2008), Ghali, J., et al.: Cardiol., 111, 147 (2008),Fórmula:C27H21ClFN3O2Cor e Forma:NeatPeso molecular:473.93Phenobarbital
CAS:Produto ControladoApplications This is a controlled substance (depressant). Anticonvulsant; sedative; hypnotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Chao, M.K.C., et al.: Anal. Profiles Drug Subs., 7, 359 (1978),Fórmula:C12H12N2O3Cor e Forma:White To Off-WhitePeso molecular:232.247-Amino Clonazepam-d4
CAS:Produto ControladoApplications A labelled major metabolite of Clonazepam (C587080). References Clark, D., et al.: Drugs, 29, 342 (1985), Colmenero, J., et al.: Antimicrob. Agents Chemother., 38, 2798 (1994), Grant, D., et al.: Pharmacology, 61, 204 (2000), Negrusz, A., et al.: Anal. Bioanal. Chem., 376, 1198 (2003),Fórmula:C152H4H8ClN3OCor e Forma:Yellow To Light Orange ColourPeso molecular:289.754-Hydroxy Midazolam (100 μg/mL in methanol)
CAS:Produto ControladoFórmula:C18H13ClFN3OCor e Forma:Single SolutionPeso molecular:341.77Phenazepam
CAS:Produto ControladoApplications A benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. References Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989), Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993), Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008),Fórmula:C15H10BrClN2OCor e Forma:Light YellowPeso molecular:349.61
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