CDK
CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.
Products of "CDK"
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PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formula:C22H25N7O2Purity:98.34% - 99.62%Color and Shape:SolidMolecular weight:419.48Milciclib
CAS:Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Formula:C25H32N8OPurity:99.28%Color and Shape:SolidMolecular weight:460.57Ref: TM-T6081
1mg51.00€5mg106.00€10mg177.00€25mg376.00€50mg603.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)110.00€BLU-222
CAS:BLU-222 is a potent, selective and orally active CDK2 inhibitor. BLU-222 shows robust antitumor activity.Formula:C15H17F2N7O2Purity:99.25% - 99.88%Color and Shape:SoildMolecular weight:365.34Ref: TM-T84321
1mg120.00€5mg283.00€10mg502.00€25mg937.00€50mg1,264.00€100mg1,700.00€1mL*10mM (DMSO)319.00€CLK1/2-IN-3
CAS:CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.Formula:C21H21N5O2Purity:98.71%Color and Shape:SolidMolecular weight:375.42Roniciclib
CAS:Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.Formula:C18H21F3N4O3SPurity:98% - 98.63%Color and Shape:SolidMolecular weight:430.44Ca2+ channel agonist 1
CAS:Ca2+ channel agonist 1 activates N-type Ca2+ channels and inhibits Cdk2 (EC50: 14.23 μM/3.34 μM) for motor nerve issues.Formula:C19H26N6OPurity:97.71%Color and Shape:SolidMolecular weight:354.45Ref: TM-T10659
1mg97.00€5mg188.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)217.00€CDK9-IN-23
CAS:CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].Formula:C22H25ClN4O3Purity:98%Color and Shape:SolidMolecular weight:428.91LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Formula:C16H12FN5OPurity:99.87%Color and Shape:SolidMolecular weight:309.3Ref: TM-T7810
1mg40.00€5mg85.00€10mg115.00€25mg224.00€50mg335.00€100mg502.00€200mg715.00€1mL*10mM (DMSO)92.00€Zeltociclib
CAS:Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.Formula:C18H20F3N4O2PColor and Shape:SolidMolecular weight:412.346CDK8-IN-4
CAS:CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Formula:C20H18N4OColor and Shape:SolidMolecular weight:330.38Indisulam
CAS:Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.Formula:C14H12ClN3O4S2Purity:98.68% - 99.77%Color and Shape:SolidMolecular weight:385.85Ref: TM-T4321
1mg35.00€2mg46.00€5mg66.00€10mg93.00€25mg137.00€50mg210.00€100mg314.00€1mL*10mM (DMSO)72.00€CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Formula:C18H18N4O2Purity:97.07%Color and Shape:SolidMolecular weight:322.36Toyocamycin
CAS:Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (Formula:C12H13N5O4Purity:98.1% - 98.17%Color and Shape:SolidMolecular weight:291.26Ref: TM-T17143
5mg47.00€10mg65.00€25mg113.00€50mg202.00€100mg354.00€500mg825.00€1mL*10mM (DMSO)50.00€THZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Formula:C31H28ClN7O2Purity:98%Color and Shape:SolidMolecular weight:566.05GSK 3 Inhibitor IX
CAS:GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.Formula:C16H10BrN3O2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:356.17Ref: TM-T1917
1mg44.00€2mg55.00€5mg82.00€10mg101.00€25mg229.00€50mg411.00€100mg610.00€500mg1,301.00€1mL*10mM (DMSO)90.00€CDK9/PARP-IN-1
CAS:CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.Formula:C38H34F2N8O3Color and Shape:SolidMolecular weight:688.725Ribociclib succinate hydrate
CAS:Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).Formula:C27H38N8O6Purity:98%Color and Shape:SolidMolecular weight:570.651CDK6-IN-1
CAS:CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Formula:C30H23N5Color and Shape:SolidMolecular weight:453.54AUZ 454
CAS:AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.Formula:C24H26F3N7O2Purity:99.59%Color and Shape:SolidMolecular weight:501.5CDK9-IN-7
CAS:CDK9-IN-7: selective, oral CDK9/cyclin T inhibitor with 11 nM IC50, stronger than CDK4/6.Formula:C29H37N7O2SPurity:98.19%Color and Shape:SolidMolecular weight:547.71Ref: TM-T10745
1mg116.00€5mg298.00€10mg432.00€25mg652.00€50mg900.00€100mg1,206.00€500mg2,432.00€1mL*10mM (DMSO)325.00€
