DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Products of "DNA Methyltransferase"
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Tazemetostat
CAS:Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Formula:C34H44N4O4Purity:98.24% - ≥95%Color and Shape:SolidMolecular weight:572.74Ref: TM-T1788
2mg38.00€5mg55.00€10mg78.00€25mg96.00€50mg97.00€100mg160.00€500mg404.00€1mL*10mM (DMSO)70.00€O6BTG-C8-αGlu
CAS:O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.Formula:C24H34BrN5O7SColor and Shape:SolidMolecular weight:616.525PRMT5-IN-48
CAS:PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).Formula:C30H37N5O3Color and Shape:SolidMolecular weight:515.646PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Color and Shape:Odour SolidGSK-3484862
CAS:Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formula:C19H19N5OSPurity:100% - 97.83%Color and Shape:SolidMolecular weight:365.45Ref: TM-T11469
1mg50.00€5mg119.00€10mg187.00€25mg335.00€50mg512.00€100mg730.00€500mg1,473.00€1mL*10mM (DMSO)215.00€EPZ004777 hydrochloride
CAS:EPZ004777 hydrochloride (EPZ004777 HCl) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.Formula:C28H42ClN7O4Color and Shape:SolidMolecular weight:576.13W4275
CAS:W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.Formula:C25H36N6O3Color and Shape:SolidMolecular weight:468.591-Hydrazinophthalazine Hydrochloride
CAS:Formula:C8H8N4·HClPurity:>99.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:196.64BI-9321 trihydrochloride
CAS:BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.Formula:C22H24Cl3FN4Purity:99.12% - 99.96%Color and Shape:SolidMolecular weight:469.81EML734
CAS:EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.Formula:C27H32N10O7Purity:98%Color and Shape:SolidMolecular weight:608.61DCLX069
CAS:DCLX069: PRMT1 inhibitor, IC50=17.9µM, targets SAM pocket, inhibits breast/liver cancer, and AML cell growth.Formula:C20H25N3O2Purity:97.76%Color and Shape:SolidMolecular weight:339.43Ref: TM-T27133
1mg38.00€2mg49.00€5mg79.00€10mg111.00€25mg187.00€50mg305.00€100mg487.00€500mg1,035.00€1mL*10mM (DMSO)92.00€3-deazaneplanocin A HCl
CAS:3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.Formula:C12H15ClN4O3Purity:93.24% - 98.34%Color and Shape:SolidMolecular weight:298.73GSK3326595
CAS:GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).Formula:C24H32N6O3Purity:97.43% - 97.7%Color and Shape:SolidMolecular weight:452.55Antitumor agent-101
CAS:Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM forFormula:C26H38N6O3Purity:98%Color and Shape:SolidMolecular weight:482.62WDR5-0102
CAS:WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.Formula:C18H19ClN4O3Purity:97.16%Color and Shape:SolidMolecular weight:374.82Ref: TM-T67947
1mg77.00€5mg169.00€10mg274.00€25mg550.00€50mg792.00€100mg1,093.00€500mg2,175.00€1mL*10mM (DMSO)215.00€Igermetostat
CAS:Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].Formula:C32H46N4O4Purity:98%Color and Shape:SolidMolecular weight:550.73Dihydro-5-azacytidine
CAS:Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.Formula:C8H14N4O5Purity:100%Color and Shape:SolidMolecular weight:246.22WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Formula:C21H25N3O4Purity:98% - 99.61%Color and Shape:SolidMolecular weight:383.44SGC-iMLLT
CAS:SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular targetFormula:C22H24N6OPurity:99.21%Color and Shape:SolidMolecular weight:388.47DC-S239
CAS:Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Formula:C15H15N3O5SPurity:99.36%Color and Shape:SolidMolecular weight:349.36Ref: TM-T60002
1mg49.00€5mg104.00€10mg169.00€25mg329.00€50mg533.00€100mg847.00€200mg1,159.00€1mL*10mM (DMSO)115.00€
