DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Products of "DNA Methyltransferase"
Sort by
Valemetostat tosylate
CAS:Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.Formula:C33H42ClN3O7SPurity:98%Color and Shape:SolidMolecular weight:660.22Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Formula:C10H8BrN5OSPurity:99.26% - 99.62%Color and Shape:SolidMolecular weight:326.17Isomaltotriose
CAS:Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.Formula:C18H32O16Purity:98%Color and Shape:Lyophilized PowderMolecular weight:504.44PRMT5-IN-1
CAS:PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).Formula:C19H19ClN4O5Purity:98%Color and Shape:SolidMolecular weight:418.83BAY-598
CAS:BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.Formula:C22H20Cl2F2N6O3Purity:98.68% - 99.18%Color and Shape:SolidMolecular weight:525.34MRK-740
CAS:MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.Formula:C25H32N6O3Purity:99.66%Color and Shape:SolidMolecular weight:464.56ORIC-944
CAS:ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Formula:C26H25FN6OPurity:98.08%Color and Shape:SolidMolecular weight:456.52Ziftomenib
CAS:Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity and can be used to study leukemia.Formula:C33H42F3N9O2S2Purity:99.65%Color and Shape:SolidMolecular weight:717.871BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Formula:C28H38N6O2·3HClPurity:99.41% - 99.95%Color and Shape:SolidMolecular weight:600.02Ref: TM-T1959
1mg44.00€2mg55.00€5mg71.00€10mg107.00€25mg192.00€50mg274.00€100mg492.00€500mg1,103.00€1mL*10mM (DMSO)139.00€5-Fluoro-2'-deoxycytidine
CAS:5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .Formula:C9H12FN3O4Purity:97.91%Color and Shape:Fine White PowderMolecular weight:245.21Ref: TM-T7718
2mg35.00€5mg50.00€10mg67.00€25mg96.00€50mg145.00€100mg210.00€200mg313.00€500mg525.00€1mL*10mM (DMSO)52.00€AMI-408
CAS:AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Formula:C20H13Cl2N6NaO5SColor and Shape:SolidMolecular weight:543.32MS9715
MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligaseFormula:C58H74FN9O5SPurity:98%Color and Shape:SolidMolecular weight:1028.33UNC6934
CAS:UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Formula:C24H21N5O4Purity:99.81%Color and Shape:SolidMolecular weight:443.45Ref: TM-T9584
1mg86.00€2mg111.00€5mg180.00€10mg283.00€25mg455.00€50mg645.00€100mg882.00€500mg1,758.00€1mL*10mM (DMSO)188.00€EEDi-5285
CAS:EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Formula:C24H22FN5O3SPurity:100%Color and Shape:SolidMolecular weight:479.53UNC6852
CAS:UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.Formula:C43H48N10O6SPurity:≥98%Color and Shape:SolidMolecular weight:832.97Ref: TM-T13954
1mg133.00€5mg274.00€10mg454.00€25mg750.00€50mg1,026.00€100mg1,406.00€1mL*10mM (DMSO)378.00€EED226
CAS:EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.Formula:C17H15N5O3SPurity:98.14% - 99.33%Color and Shape:SolidMolecular weight:369.4DW14800
CAS:DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formula:C31H36N4O3Purity:97.26% - 99.12%Color and Shape:SolidMolecular weight:512.64Ref: TM-T11131
1mg87.00€2mg130.00€5mg216.00€10mg378.00€25mg717.00€50mg948.00€100mg1,415.00€1mL*10mM (DMSO)245.00€UNC0321
CAS:UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Formula:C27H45N7O3Purity:99.25%Color and Shape:SolidMolecular weight:515.69SGC0946
CAS:SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Formula:C28H40BrN7O4Purity:98% - 99.82%Color and Shape:SolidMolecular weight:618.57
