DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Products of "DNA Methyltransferase"
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EPZ020411 hydrochloride
CAS:EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.Formula:C25H39ClN4O3Purity:100%Color and Shape:SolidMolecular weight:479.05Ref: TM-T22325
1mg60.00€5mg131.00€10mg215.00€25mg369.00€50mg563.00€100mg805.00€1mL*10mM (DMSO)145.00€DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Color and Shape:Odour Solid5-Aza-2'-deoxycytidine
CAS:Formula:C8H12N4O4Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:228.21SGI-1027
CAS:SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).Formula:C27H23N7OPurity:99.18% - 99.45%Color and Shape:SolidMolecular weight:461.52Ref: TM-T1904
5mg58.00€10mg94.00€25mg163.00€50mg296.00€100mg467.00€500mg1,035.00€1mL*10mM (DMSO)74.00€Genistein
CAS:Formula:C15H10O5Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:270.24SW155246
CAS:SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).Formula:C16H11ClN2O5SPurity:97.79%Color and Shape:SolidMolecular weight:378.79TC-E 5003
CAS:TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.Formula:C16H14Cl2N2O4SPurity:97.01%Color and Shape:SolidMolecular weight:401.26ZLD1039
CAS:ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.Formula:C36H48N6O3Purity:99.82%Color and Shape:SolidMolecular weight:612.8MRTX-1719
CAS:MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.Cost-effective and quality-assured.Formula:C23H18ClFN6O2Purity:98.27% - 99.18%Color and Shape:SolidMolecular weight:464.88Ref: TM-T40254
1mg379.00€5mg740.00€10mg1,005.00€25mg1,679.00€50mg2,355.00€100mg3,437.00€1mL*10mM (DMSO)758.00€Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formula:C27H49NO5SPurity:100% - 100%Color and Shape:SoildMolecular weight:499.75MS023 trihydrochloride
CAS:MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.Formula:C17H28Cl3N3OPurity:99.81%Color and Shape:SolidMolecular weight:396.78AS-85
CAS:AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.Formula:C26H28F3N5O3S2Purity:98.96%Color and Shape:SolidMolecular weight:579.66Levetiracetam
CAS:Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onsetFormula:C8H14N2O2Purity:98.37% - 99.67%Color and Shape:White Crystalline PowderMolecular weight:170.21UNC8153 TFA
CAS:UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormula:C35H38F3N5O7Purity:96.44%Color and Shape:SolidMolecular weight:697.7Antiproliferative agent-25
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM.Formula:C20H21BrN2O2Purity:98%Color and Shape:SolidMolecular weight:401.3NSD2-PWWP1-IN-1
CAS:NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.Formula:C28H30N4Color and Shape:SolidMolecular weight:422.565Tulmimetostat
CAS:Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advancedFormula:C28H36ClN3O5SPurity:98.04%Color and Shape:SolidMolecular weight:562.12Dot1L-IN-8
Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.Formula:C41H53N7O3SColor and Shape:SolidMolecular weight:723.97MS049
CAS:MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.Formula:C15H24N2OPurity:≥95%Color and Shape:SolidMolecular weight:248.36Ref: TM-T4378
2mg35.00€5mg51.00€10mg85.00€25mg158.00€50mg235.00€100mg354.00€200mg520.00€1mL*10mM (DMSO)55.00€Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS:Formula:C8H9ClN4Purity:98%Color and Shape:SolidMolecular weight:196.6369
