DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
Products of "DNA Methyltransferase"
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GSK2807 Trifluoroacetate
CAS:GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).Formula:C21H33F3N8O7Purity:99.95%Color and Shape:SolidMolecular weight:566.53CARM1-IN-1
CAS:CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.Formula:C26H21Br2NO3Purity:97.35%Color and Shape:SolidMolecular weight:555.26Ref: TM-T10682L
1mg37.00€5mg88.00€10mg127.00€25mg250.00€50mg406.00€100mg632.00€200mg883.00€1mL*10mM (DMSO)97.00€Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Formula:C9H16N2O6Purity:98%Color and Shape:SolidMolecular weight:248.23PRMT5-IN-2
CAS:PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.Formula:C17H16ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:394.78PRMT4-IN-3
PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37Formula:C23H29N7OPurity:98%Color and Shape:SolidMolecular weight:419.52CPUY074020
CAS:CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Formula:C25H28N4O2Purity:99.07%Color and Shape:SolidMolecular weight:416.52HLCL-61 hydrochloride
CAS:HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.Formula:C23H24N2O·ClHPurity:99.88% - 99.95%Color and Shape:SolidMolecular weight:380.91GSK126
CAS:GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).Formula:C31H38N6O2Purity:98% - 99.67%Color and Shape:SolidMolecular weight:526.67Ref: TM-T2079
2mg44.00€5mg65.00€10mg88.00€25mg152.00€50mg227.00€100mg349.00€200mg455.00€1mL*10mM (DMSO)74.00€SMYD2-IN-1
CAS:SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).Formula:C25H25Cl2F2N7O2Purity:98%Color and Shape:SolidMolecular weight:564.41LEM-14-1189
CAS:LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.Formula:C35H34N6O5S2Purity:97.98%Color and Shape:SolidMolecular weight:682.81IHMT-EZH2-426
IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5Formula:C31H35FN4O4SPurity:98%Color and Shape:SolidMolecular weight:578.7BRD0639
CAS:BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.Formula:C21H22ClN5O4SPurity:99.85%Color and Shape:SolidMolecular weight:475.95CM-272
CAS:CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.Formula:C28H38N4O3Purity:97.83%Color and Shape:SolidMolecular weight:478.63Ref: TM-T7194
1mg73.00€5mg160.00€10mg274.00€25mg512.00€50mg738.00€100mg1,035.00€1mL*10mM (DMSO)170.00€AMI-1
CAS:AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).Formula:C21H14N2Na2O9S2Purity:97.53% - 99.9%Color and Shape:DrypowderMolecular weight:548.45MI-2-2
CAS:MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.Formula:C17H20F3N5S2Purity:99.56%Color and Shape:SolidMolecular weight:415.5BCI-121
CAS:BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.Formula:C14H18BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:340.22Tazemetostat trihydrochloride
CAS:Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.Formula:C34H47Cl3N4O4Purity:98%Color and Shape:SolidMolecular weight:682.12UNC0642
CAS:UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Formula:C29H44F2N6O2Purity:98.75% - 99.5%Color and Shape:SolidMolecular weight:546.7Ref: TM-T4166
1mg40.00€2mg52.00€5mg87.00€10mg131.00€25mg230.00€50mg378.00€100mg567.00€200mg825.00€1mL*10mM (DMSO)95.00€Amodiaquine
CAS:Amodiaquine is a synthetic aminoquinoline, used to treat malaria.Formula:C20H22ClN3OPurity:99.78%Color and Shape:Crystals From Absolute Ethanol SolidMolecular weight:355.86Ref: TM-T8381
1mg52.00€2mg70.00€5mg96.00€10mg173.00€25mg304.00€50mg452.00€100mg647.00€1mL*10mM (DMSO)120.00€
