NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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INH14
CAS:INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formula:C15H16N2OPurity:95.41%Color and Shape:SolidMolecular weight:240.3Ref: TM-T5209
2mg38.00€5mg56.00€10mg84.00€25mg120.00€50mg210.00€100mg313.00€200mg452.00€1mL*10mM (DMSO)58.00€TH023
TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.Formula:C22H21ClF2N4OColor and Shape:SolidMolecular weight:430.88SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Formula:C131H234N36O31SPurity:99.86%Color and Shape:SolidMolecular weight:2841.55Asperulosidic acid
CAS:Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.Formula:C18H24O12Purity:99.47%Color and Shape:SolidMolecular weight:432.38SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Formula:C129H230N36O29S·XCF3COOHColor and Shape:SolidMolecular weight:2781.5 (free base)CLEFMA
CAS:CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Formula:C23H17Cl2NO4Purity:98.17%Color and Shape:SolidMolecular weight:442.29Ref: TM-T9582
1mg87.00€5mg192.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)219.00€Tectochrysin
CAS:Tectochrysin: antioxidant, hinders ABCG2 transport, induces apoptosis in NSC-LC by blocking STAT3 and activating DR3/Fas.Formula:C16H12O4Purity:99.26%Color and Shape:SolidMolecular weight:268.26RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.Formula:C24H16N4O2S2Purity:98%Color and Shape:SolidMolecular weight:456.54IRAK4-IN-10
CAS:IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.Formula:C22H24N8Purity:99.76%Color and Shape:SolidMolecular weight:400.48Polygalasaponin F
CAS:Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Formula:C53H86O23Purity:98% - 99.83%Color and Shape:SolidMolecular weight:1091.24Fibrinogen
CAS:Fibrinogen is a heterodimeric protein that can be cleaved by thrombin.Color and Shape:SolidHesperidin methylchalcone
CAS:Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Formula:C29H36O15Purity:99.53%Color and Shape:Yellow PowderMolecular weight:624.59(Rac)-Benpyrine
CAS:(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.Formula:C16H16N6OPurity:98.44%Color and Shape:SolidMolecular weight:308.34Ref: TM-T8692
1mg73.00€5mg124.00€10mg187.00€25mg376.00€50mg562.00€100mg802.00€500mg1,644.00€1mL*10mM (DMSO)137.00€(−)-N-Hydroxyapiosporamide
CAS:(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo.Formula:C24H31NO7Purity:98%Color and Shape:SolidMolecular weight:445.51Iron sucrose
CAS:Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.Formula:C18H24Fe2O24Purity:98%Color and Shape:SolidMolecular weight:736.1MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Formula:C26H37ClN6O2Purity:98.19%Color and Shape:SolidMolecular weight:501.07ALPK1-IN-3
CAS:ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-inducedFormula:C20H16F2N4OSPurity:98%Color and Shape:SolidMolecular weight:398.43Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formula:C54H92O23Purity:99.12% - 99.76%Color and Shape:SolidMolecular weight:1109.29Eurycomalactone
CAS:Eurycomalactone, from Eurycoma longifolia, inhibits NF-κB (IC50 0.5 μM), stops protein synthesis and cyclin D1, spares IκBα and IKK.Formula:C19H24O6Purity:98.98% - 99.87%Color and Shape:SolidMolecular weight:348.39Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formula:C25H24O6Purity:98.68% - 99.8%Color and Shape:SolidMolecular weight:420.45
