NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Products of "NF-κB"
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Sodium Aescinate
CAS:Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.Formula:C54H83NaO23Purity:95.17%Color and Shape:SolidMolecular weight:1123.21Dehydrodiisoeugenol
CAS:Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.Formula:C20H22O4Purity:99.97%Color and Shape:SolidMolecular weight:326.39Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Formula:C19H20O6Purity:99.6% - 99.71%Color and Shape:SolidMolecular weight:344.36EUK-134
CAS:EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formula:C18H18ClMnN2O4Purity:98.39%Color and Shape:SolidMolecular weight:416.74Ref: TM-T6495
10mg35.00€25mg66.00€50mg104.00€100mg160.00€200mg230.00€500mg378.00€1mL*10mM (DMSO)47.00€GSK-872
CAS:GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.Formula:C19H17N3O2S2Purity:99.3%Color and Shape:SolidMolecular weight:383.49Ref: TM-T4074
1mg38.00€5mg79.00€10mg119.00€25mg188.00€50mg321.00€100mg494.00€200mg705.00€1mL*10mM (DMSO)86.00€Anatabine dicitrate
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.Formula:C22H28N2O14Purity:98%Color and Shape:SolidMolecular weight:544.46Necrostatin-34
CAS:Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying aFormula:C18H16N4O2S2Purity:98.66% - 98.80%Color and Shape:SolidMolecular weight:384.48Ref: TM-T9095
1mg52.00€5mg116.00€10mg170.00€25mg305.00€50mg442.00€100mg615.00€200mg832.00€1mL*10mM (DMSO)135.00€HOIPIN-1
CAS:HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formula:C17H13NaO4Purity:98.83%Color and Shape:SoildMolecular weight:304.27Mangiferin
CAS:Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Formula:C19H18O11Purity:96.74% - 98.30%Color and Shape:Light Yellow PowderMolecular weight:422.34Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFormula:C24H21Cl2NO3Purity:98%Color and Shape:SolidMolecular weight:442.33CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formula:C28H28N2O6SColor and Shape:SolidMolecular weight:520.6GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formula:C22H20O8Color and Shape:SolidMolecular weight:412.39Oxaprozin
CAS:Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formula:C18H15NO3Purity:98.53%Color and Shape:SolidMolecular weight:293.32Rucaparib Phosphate
CAS:Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Formula:C19H18FN3O·H3PO4Purity:99.1%Color and Shape:SolidMolecular weight:421.36Ref: TM-T6127
1mg38.00€2mg49.00€5mg79.00€10mg115.00€25mg188.00€50mg248.00€100mg393.00€200mg585.00€1mL*10mM (DMSO)79.00€Dehydroevodiamine
CAS:Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressantFormula:C19H15N3OPurity:99.54%Color and Shape:SolidMolecular weight:301.34GSK583
CAS:GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).Formula:C20H19FN4O2SPurity:98.68% - 99.06%Color and Shape:SolidMolecular weight:398.45Ref: TM-T3537
1mg50.00€2mg71.00€5mg116.00€10mg190.00€25mg319.00€50mg465.00€100mg690.00€500mg1,444.00€1mL*10mM (DMSO)116.00€Moslosooflavone
CAS:Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Formula:C17H14O5Purity:98% - 99.78%Color and Shape:SolidMolecular weight:298.29IKK2-IN-4
CAS:IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formula:C12H11N3O2SPurity:100%Color and Shape:SolidMolecular weight:261.3Ref: TM-T36524
1mg163.00€5mg395.00€10mg605.00€25mg938.00€50mg1,264.00€100mg1,700.00€200mg2,270.00€500µg111.00€Astilbin
CAS:Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.Formula:C21H22O11Purity:97% - 99.76%Color and Shape:White PowderMolecular weight:450.39Ref: TM-T2794
5mg52.00€10mg77.00€25mg140.00€50mg224.00€100mg334.00€200mg477.00€500mg778.00€1mL*10mM (DMSO)51.00€Rucaparib monocamsylate
CAS:Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.Formula:C29H34FN3O5SPurity:99.82%Color and Shape:SolidMolecular weight:555.66Ref: TM-T16807
5mg60.00€10mg96.00€25mg160.00€50mg235.00€100mg354.00€200mg522.00€1mL*10mM (DMSO)74.00€
