TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
Products of "TLR"
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CU-CPT-9a
CAS:CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-Formula:C17H15NO2Purity:99.01%Color and Shape:SolidMolecular weight:265.31Ref: TM-T7317
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg236.00€50mg432.00€100mg638.00€1mL*10mM (DMSO)87.00€Telratolimod
CAS:Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.Formula:C36H59N5O2Purity:98.61%Color and Shape:SolidMolecular weight:593.89Ref: TM-T17032
1mg172.00€2mg235.00€5mg354.00€10mg528.00€25mg852.00€50mg1,159.00€100mg1,568.00€1mL*10mM (DMSO)462.00€Procyanidin B1
CAS:Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Formula:C30H26O12Purity:98.00% - 99.13%Color and Shape:Red-Brown PowderMolecular weight:578.52Ref: TM-TQ0205
1mg51.00€5mg170.00€10mg274.00€25mg465.00€50mg652.00€100mg920.00€1mL*10mM (DMSO)221.00€TLR7/8 agonist 3
CAS:TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.Formula:C17H23N5OPurity:99.93%Color and Shape:SolidMolecular weight:313.4Ref: TM-T13167
1mg64.00€5mg140.00€10mg226.00€25mg368.00€50mg509.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)156.00€Afimetoran
CAS:Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.Formula:C26H32N6OPurity:99.89%Color and Shape:SolidMolecular weight:444.57Ref: TM-T39654
1mg92.00€5mg187.00€10mg311.00€25mg530.00€50mg748.00€100mg1,064.00€1mL*10mM (DMSO)215.00€Enpatoran
CAS:Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).Formula:C16H15F3N4Purity:97.08% - 99.38%Color and Shape:SolidMolecular weight:320.31CU-CPT-8m
CAS:CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)Formula:C14H12N4OPurity:99.00%Color and Shape:SolidMolecular weight:252.27Ref: TM-T7347
1mg48.00€5mg88.00€10mg127.00€25mg224.00€50mg349.00€100mg528.00€200mg752.00€1mL*10mM (DMSO)106.00€AZD8848
CAS:AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.Formula:C29H43N7O5Color and Shape:SolidMolecular weight:569.7CU-115
CAS:CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.Formula:C21H11F7INO2Purity:100%Color and Shape:SolidMolecular weight:569.21ABR-238901
CAS:ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end productsFormula:C11H9BrClN3O4SPurity:99.15%Color and Shape:SolidMolecular weight:394.63Ref: TM-T39115
1mg123.00€5mg298.00€10mg472.00€25mg748.00€50mg1,026.00€100mg1,406.00€1mL*10mM (DMSO)328.00€SM-276001
CAS:SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.Formula:C16H21N7OPurity:99.37%Color and Shape:SolidMolecular weight:327.38Ref: TM-T12933
1mg64.00€5mg139.00€10mg202.00€25mg364.00€50mg547.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)153.00€TLR7/8 agonist 1
CAS:TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.Formula:C22H25N5Purity:99.4%Color and Shape:SolidMolecular weight:359.47CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formula:C17H13F3N4O2Purity:99.84%Color and Shape:SolidMolecular weight:362.31Ref: TM-T15017
1mg106.00€2mg150.00€5mg216.00€10mg283.00€25mg356.00€50mg432.00€100mg625.00€500mg1,293.00€1mL*10mM (DMSO)188.00€TLR7 agonist 1
CAS:TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Formula:C21H25N5OPurity:98%Color and Shape:SolidMolecular weight:363.46DSR-6434
CAS:DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.Formula:C19H28N8O2Purity:99.12%Color and Shape:SolidMolecular weight:400.48TLR7/8/9 antagonist 2
CAS:TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Formula:C23H31N7Purity:98%Color and Shape:SoildMolecular weight:405.54Toll-like receptor modulator
CAS:Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Formula:C15H13F5N2O2Purity:98%Color and Shape:SolidMolecular weight:348.27Semapimod tetrahydrochloride
CAS:Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor.Formula:C34H56Cl4N18O2Purity:99.8%Color and Shape:SolidMolecular weight:890.74M62812
CAS:TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.Formula:C13H13Cl2N3OSPurity:96.85%Color and Shape:SolidMolecular weight:330.23AT791
CAS:AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.Formula:C23H31N3O3Purity:99.88%Color and Shape:SolidMolecular weight:397.51Ref: TM-T61882
1mg103.00€5mg246.00€10mg395.00€25mg785.00€50mg1,130.00€100mg1,768.00€200mg2,357.00€1mL*10mM (DMSO)271.00€
