MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Products of "MAPK"
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AS601245.2TFA (345987-15-7 free base)
CAS:AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formula:C24H18F6N6O4SPurity:98%Color and Shape:SoildMolecular weight:600.50AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selectiveFormula:C29H28ClN5OPurity:98%Color and Shape:SolidMolecular weight:498.02J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formula:C17H9ClFN3O2SPurity:99.90%Color and Shape:SolidMolecular weight:373.794-(3,4-Dimethoxyphenyl)-3-buten-1-ol
CAS:'E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol could boost melanin synthesis through USF1 to treat hypopigmentation.'Formula:C12H16O3Purity:98%Color and Shape:SolidMolecular weight:208.25LY-364947
CAS:LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.Formula:C17H12N4Purity:99.41% - 99.96%Color and Shape:SolidMolecular weight:272.3Ref: TM-T2048
5mg65.00€10mg82.00€25mg143.00€50mg255.00€100mg374.00€200mg560.00€500mg877.00€1mL*10mM (DMSO)72.00€M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formula:C31H30F3N7O2Purity:98.95%Color and Shape:SolidMolecular weight:589.61LY-2584702 tosylate salt
CAS:LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.Formula:C28H27F4N7O3SPurity:98.5% - 98.51%Color and Shape:SolidMolecular weight:617.62Ref: TM-T1746
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg216.00€50mg359.00€100mg512.00€500mg1,093.00€1mL*10mM (DMSO)96.00€B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formula:C19H15N3OSPurity:98%Color and Shape:SolidMolecular weight:333.41BSc5367
CAS:BSc5367 is a potent inhibitor of the structural domain of Nek1 kinase.cell cycle regulation, DNA repair, and microtubule regulation. ALS, PKD.Formula:C20H15N3O2Purity:98.72%Molecular weight:329.35Ref: TM-T201389
1mg97.00€5mg170.00€10mg269.00€25mg565.00€50mg877.00€100mg1,366.00€1mL*10mM (DMSO)185.00€methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS:methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.Formula:C13H13NO5Purity:97.69%Color and Shape:SolidMolecular weight:263.25LM22B-10
CAS:LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formula:C27H33ClN2O4Purity:98.18%Color and Shape:SolidMolecular weight:485.01NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47MHJ-627
MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leadingFormula:C34H45BrN2O3Purity:98%Color and Shape:SolidMolecular weight:609.64Anti-ERK2 Antibody (4F551)
Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.Color and Shape:Odour LiquidPLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formula:C17H14ClF2N3O3SPurity:97.78% - 99.83%Color and Shape:SolidMolecular weight:413.83PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Formula:C22H19BrF2N2O3Purity:97.79% - 97.90%Color and Shape:SolidMolecular weight:477.3Ref: TM-T1974
1mg46.00€5mg94.00€10mg144.00€25mg255.00€50mg406.00€100mg628.00€500mg1,320.00€1mL*10mM (DMSO)97.00€MK-8353
CAS:MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)Formula:C37H41N9O3SPurity:96.15% - 99.89%Color and Shape:SolidMolecular weight:691.84Ref: TM-T12069
1mg81.00€5mg156.00€10mg271.00€25mg620.00€50mg938.00€100mg1,454.00€1mL*10mM (DMSO)230.00€CAY10404
CAS:CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.Formula:C17H12F3NO3SPurity:99.02%Color and Shape:SolidMolecular weight:367.34Ref: TM-T8656
2mg35.00€5mg52.00€10mg96.00€25mg177.00€50mg304.00€100mg437.00€200mg615.00€1mL*10mM (DMSO)58.00€BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formula:C15H12ClN5OPurity:97.58%Color and Shape:SolidMolecular weight:313.74SGX-523
CAS:SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.Formula:C18H13N7SPurity:100% - 99.49%Color and Shape:SolidMolecular weight:359.41
