Ras
Ras proteins are small GTPases that act as molecular switches in the MAPK signaling pathway, controlling cell growth, differentiation, and survival. Activated Ras initiates a signaling cascade that includes Raf, MEK, and ERK, leading to various cellular responses. Mutations in Ras genes are common in cancers, making Ras an important focus of cancer research. At CymitQuimica, we offer a range of Ras modulators to support your research in cancer biology, signal transduction, and therapeutic development.
Products of "Ras"
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Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Formula:C26H28BrF3N4O2Purity:98%Color and Shape:SolidMolecular weight:565.43Phellodendrine chloride
CAS:Phellodendrine chloride combats kidney inflammation by blocking macrophage and T cell activity in glomeruli.Formula:C20H24ClNO4Purity:98.85% - 99.05%Color and Shape:SolidMolecular weight:377.86AMG410
CAS:AMG410 is a non-covalent, bimodal GDP (OFF) and GTP (ON)-binding pan-KRAS inhibitor , binds on the variegated pocket, in KRAS G12D, G12V, G12C, G13D.Formula:C31H32ClF2N7O5Color and Shape:SoildMolecular weight:656.08AM-001
CAS:AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Formula:C24H16FN3OS2Color and Shape:SolidMolecular weight:445.53KRAS G12D inhibitor 25
CAS:KRAS G12D inhibitor 25 (Compound 148) acts as an inhibitor for KRAS G12C and HSP90α, displaying IC50 values of <0.1 μM and 0.1-1 μM respectively. Additionally, it suppresses the proliferation of MIA PaCa-2 and NCI-H358 cell lines, with EC50 values of <0.1 μM and 0.1-1 μM correspondingly. This compound also promotes the degradation of ERBB2, exhibiting a DC50 of 0.1-1 μM.Formula:C56H62ClN11O6Color and Shape:SolidMolecular weight:1020.62ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Formula:C21H19BrClN5O4S2Purity:96.29% - 99.72%Color and Shape:SolidMolecular weight:584.89Ref: TM-T1855
5mg50.00€10mg79.00€25mg136.00€50mg221.00€100mg310.00€200mg497.00€500mg805.00€1mL*10mM (DMSO)79.00€KRAS inhibitor-34
CAS:KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.Formula:C43H41F3N6O3Color and Shape:SolidMolecular weight:746.82ARS-1620
CAS:ARS-1620 is a covalent inhibitor of K-RASG12C.Formula:C21H17ClF2N4O2Purity:98.86%Color and Shape:SolidMolecular weight:430.84Ref: TM-T7609
1mg92.00€2mg117.00€5mg188.00€10mg274.00€25mg543.00€50mg780.00€100mg938.00€1mL*10mM (DMSO)212.00€K-Ras(G12C) inhibitor 12
CAS:K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C15H17ClIN3O3Purity:97.16%Color and Shape:SolidMolecular weight:449.67MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formula:C33H39N7O2Purity:96.59% - 99.07%Color and Shape:SolidMolecular weight:565.71Ref: TM-T16143
1mg64.00€2mg89.00€5mg131.00€10mg220.00€25mg371.00€50mg557.00€100mg797.00€1mL*10mM (DMSO)170.00€Kobe0065
CAS:Kobe0065: novel small-molecule, inhibits Ras-Raf, Ki=46±13 μM, blocks H-Ras·GTP/c-Raf-1 RBD binding.Formula:C15H11ClF3N5O4SPurity:100% - 99.58%Color and Shape:SolidMolecular weight:449.79BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formula:C25H28N4O2SPurity:96.8%Color and Shape:SolidMolecular weight:448.586H05 (TFA)
CAS:6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Formula:C22H31ClF3N3O4S3Purity:≥95%Color and Shape:SolidMolecular weight:590.14Ref: TM-T7326
1mg69.00€2mg95.00€5mg134.00€10mg230.00€25mg378.00€50mg568.00€100mg807.00€1mL*10mM (DMSO)170.00€TH-Z835
CAS:TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM.Formula:C30H38N6OPurity:98%Color and Shape:SolidMolecular weight:498.66RMC-6236
CAS:RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Formula:C44H58N8O5SPurity:98.24% - 99.92%Color and Shape:SolidMolecular weight:811.05K-Ras(G12C) Inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Formula:C17H22Cl2N2O3SPurity:89.07% - 97.09%Color and Shape:SolidMolecular weight:405.33Ref: TM-T3725
1mg63.00€2mg88.00€5mg133.00€10mg230.00€25mg477.00€50mg667.00€100mg932.00€1mL*10mM (DMSO)133.00€BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formula:C47H62N8O4SColor and Shape:SolidMolecular weight:835.11MLS000532223
CAS:MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).Formula:C15H9NO3Purity:98.60%Color and Shape:SolidMolecular weight:251.24Ref: TM-T8473
1mg130.00€2mg183.00€5mg306.00€10mg462.00€25mg755.00€50mg1,035.00€100mg1,415.00€1mL*10mM (DMSO)319.00€1A-116
CAS:1A-116 is a specific Rac1 inhibitor.Formula:C16H16F3N3Purity:98.43%Color and Shape:SolidMolecular weight:307.31Ref: TM-T14004
1mg50.00€5mg111.00€10mg166.00€25mg283.00€50mg444.00€100mg655.00€200mg924.00€1mL*10mM (DMSO)123.00€(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Formula:C30H30F2N6O3Purity:98.01% - 99.76%Color and Shape:SolidMolecular weight:560.59Ref: TM-T22258
2mg37.00€5mg52.00€10mg85.00€25mg156.00€50mg274.00€100mg426.00€500mg938.00€1mL*10mM (DMSO)77.00€
