p38 MAPK
p38 MAPKs are a subgroup of MAPKs that respond to stress signals and are involved in the regulation of inflammation, cell differentiation, apoptosis, and autophagy. p38 MAPK signaling is crucial in immune responses and is implicated in various diseases, including chronic inflammatory conditions, cancer, and neurodegenerative disorders. At CymitQuimica, we provide a comprehensive range of p38 MAPK inhibitors and modulators to support your research in inflammation, stress response, and therapeutic development.
Products of "p38 MAPK"
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SD-169
CAS:SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.Formula:C9H8N2OPurity:98.60%Color and Shape:SolidMolecular weight:160.17N-Feruloyloctopamine
CAS:N-Feruloyloctopamine is a natural product.Formula:C18H19NO5Purity:99.67%Color and Shape:SolidMolecular weight:329.35Ref: TM-TN1968
1mg89.00€5mg207.00€10mg304.00€25mg512.00€50mg740.00€100mg1,035.00€1mL*10mM (DMSO)172.00€Z16078526
CAS:Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Formula:C18H17N3O4SPurity:98.93%Color and Shape:SolidMolecular weight:371.41Ro-3201195
CAS:Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.Formula:C19H18FN3O4Purity:100%Color and Shape:SolidMolecular weight:371.36PD 169316
CAS:PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.Formula:C20H13FN4O2Purity:98.65%Color and Shape:SolidMolecular weight:360.34RWJ-67657
CAS:RWJ-67657 is a selective oral p38α/β MAPK inhibitor with IC50s of 1/11μM; inactive on p38γ/δ with cardioprotection.Formula:C27H24FN3OPurity:99.66%Color and Shape:SolidMolecular weight:425.5Ref: TM-T16812
2mg47.00€5mg70.00€10mg96.00€25mg216.00€50mg349.00€100mg563.00€500mg1,188.00€1mL*10mM (DMSO)77.00€PLK1/p38γ-IN-1
CAS:PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellularFormula:C21H26ClN3O2Purity:98%Color and Shape:SolidMolecular weight:387.9ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Formula:C19H19N9O2Purity:99.52%Color and Shape:SolidMolecular weight:405.41Ref: TM-T9697
1mg90.00€5mg215.00€10mg321.00€25mg582.00€50mg873.00€100mg1,216.00€1mL*10mM (DMSO)236.00€Isoliquiritin apioside
CAS:Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Formula:C26H30O13Purity:98.84% - 99.27%Color and Shape:SolidMolecular weight:550.51SB-203580
CAS:Controlled ProductStability -200C Applications A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase. References Kawasaki, H., et al.: J. Biol. Chem., 272, 18518 (1997), Ward, S.G., et al.: Biochem. Soc. Trans., 245, 304S (1997), Clerk, A., et al.: FEBS Lett., 426, 93 (1998),Formula:C21H16FN3OSColor and Shape:NeatMolecular weight:377.4310-Methoxy-canthin-6-one
CAS:10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC). Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.Formula:C15H10N2O2Color and Shape:SolidMolecular weight:250.25Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Formula:C8H12ClNO3Purity:96.17% - 99.85%Color and Shape:Physical Description Beige Solid (Ntp 1992)Molecular weight:205.64p38-α MAPK-IN-1
CAS:p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.Formula:C27H35N5O3Purity:99.52%Color and Shape:SolidMolecular weight:477.6Ref: TM-T12347
1mg88.00€5mg180.00€10mg281.00€25mg520.00€50mg777.00€100mg1,169.00€200mg1,568.00€1mL*10mM (DMSO)188.00€SB 203580 Hydrochloride
CAS:Controlled ProductFormula:C21H16FN3OS·HClColor and Shape:NeatMolecular weight:377.43 + 36.46AS-252424
CAS:Controlled ProductApplications AS-252424 is a novel, potent, and selective phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor. It is also an inhibitor of Casein kinase and PI3K p110α. References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Edling, C.E., et al.: Clin. Cancer Res., 16, 4928 (2010); Condliffe, A.M., et al.: Blood, 106, 1432 (2005)Formula:C14H8FNO4SColor and Shape:NeatMolecular weight:305.28LY 294002 Hydrochloride
CAS:Controlled ProductApplications LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590). References Lin, C., et. al.: J. Biol. Chem., 286, 10483 (2011); Cao, H., et. al.: J. Biol. Chem., 288, 30399 (2013);Formula:C19H17NO3·(HCl)Color and Shape:NeatMolecular weight:343.8
