P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Products of "P-gp"
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Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Formula:C32H31F2N3O2Color and Shape:SolidMolecular weight:527.6Evodine
CAS:1. Evodine has antinociceptive activity.Formula:C18H19NO5Purity:98%Color and Shape:SolidMolecular weight:329.35Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Formula:C19H18O8Purity:97.43% - 98.53%Color and Shape:SolidMolecular weight:374.34Ref: TM-TJS1159
1mg60.00€5mg127.00€10mg188.00€25mg348.00€50mg512.00€100mg730.00€500mg1,483.00€1mL*10mM (DMSO)226.00€Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Formula:C32H31F2N3O2·3HClPurity:100% - 99.55%Color and Shape:SolidMolecular weight:636.99PGP-4008
CAS:PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Formula:C26H23N3OPurity:98% - 98.53%Color and Shape:SolidMolecular weight:393.48Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formula:C21H21F2N3OSPurity:99.58%Color and Shape:SolidMolecular weight:401.47Ref: TM-T13383
1mg96.00€5mg205.00€10mg309.00€25mg557.00€50mg838.00€100mg1,216.00€1mL*10mM (DMSO)221.00€Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurity:98.3% - 99.46%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:407.5Ceefourin 1
CAS:Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Formula:C11H10N4S3Purity:99.15%Color and Shape:SolidMolecular weight:294.42Ref: TM-T8596
1mg43.00€5mg88.00€10mg119.00€25mg250.00€50mg389.00€100mg550.00€200mg785.00€1mL*10mM (DMSO)87.00€Voacamine
CAS:Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.Formula:C43H52N4O5Purity:98.54%Color and Shape:SolidMolecular weight:704.9Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formula:C39H37F3N4O5Purity:98.74%Color and Shape:SoildMolecular weight:698.73YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Formula:C37H35BrN4O3Purity:97.50%Color and Shape:SolidMolecular weight:663.6Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formula:C38H38N4O6Purity:98.07% - 99.17%Color and Shape:SolidMolecular weight:646.73Larotaxel
CAS:Larotaxel (XRP9881), a taxane with anticancer properties, stabilizes microtubules, induces apoptosis, and is researched in breast and bladder cancer.Formula:C45H53NO14Purity:99.22%Color and Shape:SolidMolecular weight:831.9Encequidar mesylate
CAS:Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.Formula:C39H40N6O10SPurity:99.84%Color and Shape:SolidMolecular weight:784.83Ref: TM-T11578L
2mg42.00€5mg62.00€10mg88.00€25mg155.00€50mg250.00€100mg393.00€500mg893.00€1mL*10mM (DMSO)74.00€Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formula:C27H39ClN2O4Purity:98.7% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:491.06Atazanavir
CAS:Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Formula:C38H52N6O7Purity:98% - 99.95%Color and Shape:Crystalline SolidMolecular weight:704.86Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formula:C38H52N6O7·H2SO4Purity:99.31% - 99.40%Color and Shape:SolidMolecular weight:802.93Ref: TM-T0100
5mg47.00€10mg62.00€25mg95.00€50mg120.00€100mg180.00€200mg264.00€500mg449.00€1mL*10mM (DMSO)52.00€Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Formula:C16H24NO5Purity:98% - 99.85%Color and Shape:White Or Light-Tan SolidMolecular weight:310.37Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purity:99.84%Color and Shape:SolidMolecular weight:769.96ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Formula:C32H38N4OPurity:98.86%Color and Shape:SolidMolecular weight:494.67
