P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Products of "P-gp"
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Dofequidar fumarate
CAS:Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through theFormula:C34H35N3O7Purity:99.43%Color and Shape:SolidMolecular weight:597.66Ref: TM-T11071
1mg39.00€2mg50.00€5mg85.00€10mg125.00€25mg245.00€50mg472.00€100mg687.00€500mg1,444.00€1mL*10mM (DMSO)96.00€Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formula:C20H20O7Purity:99.05% - ≥95%Color and Shape:SolidMolecular weight:372.37P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formula:C30H28N2O6Purity:99.58%Color and Shape:SoildMolecular weight:512.55FM04
CAS:FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.Formula:C26H25NO4Purity:99.84%Color and Shape:SolidMolecular weight:415.48Talinolol
CAS:(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Formula:C20H33N3O3Purity:98.80%Color and Shape:SolidMolecular weight:363.49Ref: TM-T21640
2mg35.00€5mg50.00€10mg96.00€25mg188.00€50mg329.00€100mg565.00€200mg818.00€1mL*10mM (DMSO)55.00€Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formula:C27H38N2O4Purity:99.53%Color and Shape:OilMolecular weight:454.6Ref: TM-T20656
10mg35.00€25mg51.00€50mg73.00€100mg96.00€200mg143.00€500mg230.00€1mL*10mM (DMSO)55.00€(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormula:C30H52O3Purity:98.03% - 98.91%Color and Shape:SolidMolecular weight:460.73Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purity:99.27%Color and Shape:Prisms From Methanol + Ether SolidMolecular weight:550.64Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurity:99.57% - 99.96%Color and Shape:Cream Fine PowderMolecular weight:480.43
