Sodium Channel

SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated

Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.

Applications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes. References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),

Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.

Stability Hygroscopic Applications Antiepileptic; increases levels of GABA in the brain. References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979), Nau, H., et al.: Pharmacol. Toxicol., 69, 310 (1991), Loscher, W., et al.: Prog. Neurobiol., 58, 31 (1999)

Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.

Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer.

Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.

Stability Light Sensitive Applications 2-Chloro-2',6'-dimethyl-d6-acetanilide is the labeled analogue of 2-Chloro-2',6'-dimethylacetanilide (C365375), an intermediate of Lidocaine (L397800), a local anesthetic; antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. References Moen, A., et al.: Biocatal. Biotransform., 23, 45 (2005); Yogeeswari, P., et al.: Bioorg. Med. Chem. Lett., 17, 3712 (2007); Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971); Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973); Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985); Davies, P.S., et al.: Drugs, 64, 937 (2004)

Applications Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant. Neuroprotective & Neuroresearch Product. References Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995), Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998), Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),

Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .

Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.

Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.

NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。

Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.

Applications Labelled Rufinamide (R701552). Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant. References Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995), Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998), Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),

Applications Labelled analogue of a local anesthetic with stimulant properties. Studies have shown its potency to be about half that of Cocaine (C633500). References Wppdward, J.J. et al.: Eur. J. Pharmacol., 277, 7 (1995); Rigon, A.R. et al.: Psychopharmacol., 127, 323 (1996); Wilcox, K.M. et al.: Synapse, 58, 220 (2005);

Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.