Sodium Channel
Sodium channels are essential membrane proteins that allow the passage of sodium ions (Na+) across the cell membrane, generating and propagating electrical signals in neurons, muscle cells, and other excitable tissues. These channels are vital for the initiation and conduction of action potentials, making them crucial in processes such as nerve impulse transmission, muscle contraction, and cardiac function. Dysregulation of sodium channels can lead to neurological disorders, arrhythmias, and chronic pain conditions. At CymitQuimica, we provide a variety of sodium channel modulators to support your research in neurobiology, cardiology, and pain management.
Products of "Sodium Channel"
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Oxethazaine
CAS:Controlled ProductApplications A potent local anesthetic that is active even in acidic conditions. It is used (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. References Detrain, M. et al.: Acta. Gastro-Enterol. Belg., 28, 360 (1965); Barbezat, G.O. et al.: Scand. J. Gastroenterol., 13, 321 (1978); Masuda, Y. et al.: Biochem. Pharmacol., 64, 677 (2002);Formula:C28H41N3O3Color and Shape:NeatMolecular weight:467.64Metaflumizone
CAS:Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.Formula:C24H16F6N4O2Purity:≥95%Color and Shape:SolidMolecular weight:506.4AZ194
CAS:CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.Formula:C34H31F2N3O3Purity:99.86%Color and Shape:SolidMolecular weight:567.62Ref: TM-T9461
1mg81.00€5mg170.00€10mg274.00€25mg512.00€50mg740.00€100mg1,035.00€500mg2,072.00€1mL*10mM (DMSO)188.00€Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82Amlenetug
Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Color and Shape:Odour LiquidRopivacaine hydrochloride
CAS:Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activityFormula:C17H26N2O·HClPurity:99.85%Color and Shape:SolidMolecular weight:310.86Lorcainide Hydrochloride
CAS:Controlled ProductApplications Lorcainide Hydrochloride is an inhibitor of sodium voltage-gated channels. Effective anti-arrhythmic agents in patients. References Lynch, J. J., et al.: J. Pharm. Exp. Ther., 273, 554-560 (1995); Heykants, J.: Int. Congr. Symp., 49, 35-39 (1981)Formula:C22H27ClN2O·ClHColor and Shape:NeatMolecular weight:407.38Analgesic agent-2
Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the humanFormula:C21H21ClF2N4O2Purity:98%Color and Shape:SolidMolecular weight:434.876-Chlorohexanoic Acid
CAS:Controlled ProductApplications 6-Chlorohexanoic Acid is used as the starting material in the synthesis of 2,6-Dichloro-N-(2,6-dimethylphenyl)hexanamide (D434225); an impurity of the local anesthetic Levobupivacaine (B689546). 6-Chlorohexanoic Acid is also used as a reagent in the synthesis of novel types of polyester glycodendrimers as potential inhibitors of urinary tract infections. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tullar, B., et al.: J. Med. Chem., 14, 891 (1971); Schmidt, A., et al.: Pharm. Res., 22, 2121 (2005); Twibanire, J.K., et al.: New J. Chem., 39, 4115 (2015)Formula:C6H11ClO2Color and Shape:NeatMolecular weight:150.6Ralitoline
CAS:Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.Formula:C13H13ClN2O2SPurity:98.73%Color and Shape:SolidMolecular weight:296.77Ambroxol hydrochloride
CAS:Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract.Formula:C13H18Br2N2O·HClPurity:99.70%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:414.56Benzocaine-d4
CAS:Controlled ProductApplications Labelled Benzocaine (B202970). Benzocaine is used as an anesthetic (local). References Ali, S.L., et al.: Anal. Profiles Drug Subs., 12, 73 (1983),Formula:C92H4H7NO2Color and Shape:NeatMolecular weight:169.21Ethyl N-Boc-piperidine-4-carboxylate
CAS:Controlled ProductApplications Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme. References Levin. J.: Heterocycles, 70, 691 (2006); Seki, M., et al.: Chem. Pharm. Bull., 60, 488 (2012)Formula:C13H23NO4Color and Shape:NeatMolecular weight:257.33Bupivacaine hydrochloride
CAS:Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.Formula:C18H28N2O·HClPurity:100% - 100%Color and Shape:SolidMolecular weight:324.896-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Controlled ProductApplications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic. References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),Formula:C17H28N2O2Color and Shape:NeatMolecular weight:292.416Ropivacaine Hydrochloride Monohydrate
CAS:Controlled ProductApplications Anesthetic (local). References Cederholm. I., et al.: Reg. Anesth., 19, 18 (1994), Johansson, B., et al.: Anesth. Analg., 78, 210 (1994), Oda, Y., et al.: Anesthesiology, 82, 214 (1995),Formula:C17H26N2OColor and Shape:White SolidMolecular weight:328.88GNE-131
CAS:GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).Formula:C23H30N4O3SPurity:98.54% - 99.59%Color and Shape:SolidMolecular weight:442.57Ref: TM-TQ0014
1mg120.00€5mg264.00€10mg376.00€25mg630.00€50mg880.00€100mg1,169.00€1mL*10mM (DMSO)283.00€PF-04885614
CAS:PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment.Formula:C13H14F3N3OPurity:98.02%Color and Shape:SolidMolecular weight:285.27Ref: TM-T12421
1mg48.00€2mg65.00€5mg96.00€10mg153.00€25mg283.00€50mg527.00€100mg743.00€500mg1,568.00€1mL*10mM (DMSO)96.00€
