PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Products of "PDE"
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Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Formula:C21H23N7O2Purity:98%Color and Shape:SolidMolecular weight:405.45NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Formula:C17H19N3O2Purity:99.10%Color and Shape:SolidMolecular weight:297.35Ref: TM-T12267
1mg52.00€5mg116.00€10mg187.00€25mg325.00€50mg467.00€100mg645.00€200mg872.00€1mL*10mM (DMSO)128.00€MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Formula:C19H22N6OSPurity:100% - 99.67%Color and Shape:SolidMolecular weight:382.48Tovinontrine
CAS:Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.Formula:C21H26N6O2Purity:98.14%Color and Shape:SolidMolecular weight:394.47FCPR03
CAS:FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.Formula:C15H19F2NO3Purity:100.00%Color and Shape:SolidMolecular weight:299.31Ref: TM-T39341
1mg52.00€2mg75.00€5mg116.00€10mg183.00€25mg311.00€50mg444.00€100mg605.00€200mg815.00€1mL*10mM (DMSO)128.00€T-0156
CAS:T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.Formula:C31H29N5O7Purity:100% - 98.42%Color and Shape:SoildMolecular weight:583.59Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C30H39ClN6O4S2Purity:98%Color and Shape:SolidMolecular weight:647.25Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Formula:C13H12N4OPurity:98.56% - 99.36%Color and Shape:SolidMolecular weight:240.26Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Formula:C13H13ClN4OPurity:99.84%Color and Shape:SolidMolecular weight:276.72Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFormula:C17H14Cl2F2N2O3Purity:100.00% - 99.76%Color and Shape:SolidMolecular weight:403.21BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Formula:C9H12N2O4SPurity:99.66%Color and Shape:SolidMolecular weight:244.27Autotaxin-IN-3
CAS:Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.Formula:C22H21N9O2Purity:98.49% - 99.21%Color and Shape:SolidMolecular weight:443.46Ref: TM-T10415
2mg46.00€5mg70.00€10mg101.00€25mg183.00€50mg284.00€100mg455.00€200mg625.00€1mL*10mM (DMSO)78.00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Formula:C13H16O3Purity:99.54%Color and Shape:SolidMolecular weight:220.26PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Formula:C25H21N3O6SPurity:98%Color and Shape:SolidMolecular weight:491.52Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Formula:C23H33N7O5SPurity:98.25% - 99.06%Color and Shape:SolidMolecular weight:519.62Ref: TM-T15381
1mg185.00€5mg415.00€10mg613.00€25mg938.00€50mg1,311.00€100mg1,768.00€1mL*10mM (DMSO)520.00€Pumafentrine
CAS:Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Formula:C29H39N3O3Purity:99.79%Color and Shape:SolidMolecular weight:477.64PF-05085727
CAS:PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.Formula:C20H18F3N7Purity:98%Color and Shape:SolidMolecular weight:413.4OPC18750 HCl
CAS:OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Formula:C20H23ClN2O4Purity:98.92%Color and Shape:SoildMolecular weight:390.86Ref: TM-T83974
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€1mL*10mM (DMSO)47.00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Formula:C25H20N4OPurity:99.87%Color and Shape:SolidMolecular weight:391.45YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Formula:C17H16ClN3OPurity:99.84%Color and Shape:SolidMolecular weight:313.78
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