Carbonic Anhydrase
Carbonic anhydrase is an enzyme that catalyzes the reversible conversion of carbon dioxide and water into bicarbonate and protons. This enzyme plays a crucial role in maintaining acid-base balance, respiration, and the transport of carbon dioxide in the blood. Inhibitors of carbonic anhydrase are used in the treatment of glaucoma, epilepsy, and altitude sickness, as well as in research on acid-base homeostasis and gas exchange. At CymitQuimica, we offer a range of high-quality carbonic anhydrase inhibitors and reagents to support your research in enzymology, respiratory physiology, and therapeutic development.
Products of "Carbonic Anhydrase"
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Carbonic anhydrase inhibitor 15
Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1].Formula:C27H33N5O2S2Purity:98%Color and Shape:SolidMolecular weight:523.71SH7s
SH7s is an effective carbonic anhydrase inhibitor, exhibiting Ki values of 15.9 nM for hCA IX and 55.2 nM for hCA XII. Additionally, SH7s acts as a hypoxia-mediated chemosensitizer in colorectal cancer cells.Formula:C24H19ClF3N5O4SColor and Shape:SolidMolecular weight:565.95Polmacoxib
CAS:Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.Formula:C18H16FNO4SPurity:97.88%Color and Shape:SolidMolecular weight:361.39Ref: TM-T21294
2mg47.00€5mg70.00€10mg107.00€25mg173.00€50mg259.00€100mg378.00€200mg563.00€1mL*10mM (DMSO)77.00€ALP/Carbonic anhydrase-IN-1
CAS:Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkalineFormula:C15H16N2Purity:98%Color and Shape:SolidMolecular weight:224.3CAIX/CAXII-IN-4
CAIX/CAXII-IN-4 (Compound 7h) is an inhibitor of carbonic anhydrase (CA) that binds to CAIX, CA XII, and CAII with Ki values of 1.324 μM, 0.435 μM, and 3.035 μM, respectively. This compound exhibits broad-spectrum anti-tumor activity and inhibits the proliferation of central nervous system tumor cells U251, with a GI50 of 0.361 μM.Formula:C23H21N5O3SColor and Shape:SolidMolecular weight:447.51CAIX/CAXII-IN-3
CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.Color and Shape:Odour SolidWES-1
CAS:WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines,Formula:C20H20N4O3SPurity:98%Color and Shape:SolidMolecular weight:396.46Zonisamide
CAS:Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.Formula:C8H8N2O3SPurity:99.05% - 99.9%Color and Shape:Off-White PowderMolecular weight:212.23hCAII/XII-IN-1
hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Ki values of 8.4 nM and 9.4 nM, respectively. It plays a significant role in cancer research.Formula:C22H20N4O6S2Molecular weight:500.547Chlorothiazide
CAS:Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.Formula:C7H6ClN3O4S2Purity:95.42%Color and Shape:Crystals Physical Description Crystals; White Powder (Ntp 1992)Molecular weight:295.72hCAII-IN-9
CAS:hCAII-IN-9 inhibits hCA II/IX/XII with IC50s of 1.18, 0.17, 2.99 μM; not BBB permeable.Formula:C15H16ClN3O5S2Purity:98.63%Color and Shape:SolidMolecular weight:417.89Carbonic anhydrase inhibitor 12
CAS:CA Inhibitor 12 strongly blocks CA II (K_i 1.72 nM), also inhibits CA I (271 nM), shows anticancer effects.Formula:C27H22BrN5O5S2Purity:98%Color and Shape:SolidMolecular weight:640.53CA Ⅱ-IN-1
CAⅡ-IN-1 (compound 2i) is an inhibitor of the CA Ⅱ isozyme, exhibiting an IC50 of 0.44 µM. This compound is utilized in metabolic research.Formula:C18H19NO6SColor and Shape:SolidMolecular weight:377.41U-104
CAS:U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).Formula:C13H12FN3O3SPurity:100% - 99.6%Color and Shape:SolidMolecular weight:309.32Ref: TM-T2017
5mg35.00€10mg52.00€25mg87.00€50mg142.00€100mg250.00€200mg399.00€500mg652.00€1mL*10mM (DMSO)58.00€Dichlorphenamide
CAS:Dichlorphenamide (Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.Formula:C6H6Cl2N2O4S2Purity:96.87% - 98.51%Color and Shape:Needles From Dimethylsulfoxide + Water SolidMolecular weight:305.16Ref: TM-T6469
5mg50.00€10mg65.00€25mg87.00€50mg96.00€100mg140.00€200mg202.00€500mg340.00€1mL*10mM (DMSO)59.00€CAIX Inhibitor S4
CAS:CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively.Formula:C15H17N3O4SPurity:98.35%Color and Shape:SolidMolecular weight:335.38Ref: TM-T36758
2mg40.00€5mg60.00€10mg96.00€25mg188.00€50mg354.00€100mg528.00€500mg1,159.00€1mL*10mM (DMSO)66.00€EMAC10101d
CAS:compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with anFormula:C17H15Cl2N3O2S2Purity:99.96%Color and Shape:SolidMolecular weight:428.36hCAI/II/IV-IN-28
CAS:hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity.Formula:C14H15N3O3SPurity:96.48%Color and Shape:SolidMolecular weight:305.35Carbonic anhydrase inhibitor 26
Compound 6T, designated as Carbonic anhydrase inhibitor26, acts as an inhibitor of Carbonic Anhydrase II (Carbonic AnhydraseII), exhibiting an IC50 value of 9.10 ± 0.26 μM.Formula:C17H14N6O4Color and Shape:SolidMolecular weight:366.33Perfluorohexane sulfonamide
CAS:Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.Formula:C6H2F13NO2SColor and Shape:SolidMolecular weight:399.13
