PPAR
Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes involved in metabolism, particularly fatty acid storage and glucose metabolism. PPAR inhibitors are important tools for studying metabolic disorders such as diabetes, obesity, and cardiovascular diseases. These inhibitors can modulate lipid metabolism, insulin sensitivity, and inflammation, making them valuable in therapeutic research. At CymitQuimica, we offer a range of PPAR inhibitors to support your research in metabolic diseases, endocrinology, and drug development.
Products of "PPAR"
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LG100754
CAS:LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.Formula:C26H36O3Color and Shape:SolidMolecular weight:396.56AMG131
CAS:AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used forFormula:C21H12Cl4N2O3SPurity:99.37%Color and Shape:SolidMolecular weight:514.21SR1664
CAS:SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity.Formula:C33H29N3O5Purity:98.02%Color and Shape:SolidMolecular weight:547.6Ref: TM-T23389
1mg52.00€2mg74.00€5mg111.00€10mg144.00€25mg305.00€50mg543.00€100mg780.00€500mg1,605.00€1mL*10mM (DMSO)123.00€NSC-87877 disodium
CAS:NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.Formula:C19H13N3O7S2·2NaPurity:97.89%Color and Shape:SolidMolecular weight:503.42CC618
CAS:CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.Formula:C20H15F6N3O3S2Purity:99.37%Color and Shape:SolidMolecular weight:523.47Ref: TM-T9767
1mg115.00€5mg249.00€10mg369.00€25mg562.00€50mg787.00€100mg1,054.00€200mg1,406.00€1mL*10mM (DMSO)314.00€PPARγ agonist 8
CAS:PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferatorFormula:C19H12F4O2SPurity:98%Color and Shape:SolidMolecular weight:380.36Clofibric acid
CAS:Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.Formula:C10H11ClO3Purity:99.47% - 99.8%Color and Shape:Pale Yellow SolidMolecular weight:214.65OPHIOPOGONIN D
CAS:Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.Formula:C44H70O16Purity:99.46% - ≥95%Color and Shape:SolidMolecular weight:855.02CDDO-Im
CAS:CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).Formula:C34H43N3O3Purity:100% - 98.3%Color and Shape:SolidMolecular weight:541.72Ref: TM-TQ0120
1mg37.00€5mg79.00€10mg111.00€25mg210.00€50mg338.00€100mg512.00€500mg1,093.00€1mL*10mM (DMSO)94.00€Rosiglitazone
CAS:Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.Formula:C18H19N3O3SPurity:98.61% - 99.87%Color and Shape:White To Off-White Crystalline PowderMolecular weight:357.43Daltroban
CAS:Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.Formula:C16H16ClNO4SPurity:99.49%Color and Shape:SolidMolecular weight:353.82Ref: TM-T15049
1mg58.00€5mg129.00€10mg187.00€25mg311.00€50mg444.00€100mg605.00€200mg815.00€1mL*10mM (DMSO)117.00€AVE-8134
CAS:AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.Formula:C22H23NO5Purity:98%Color and Shape:SolidMolecular weight:381.42PPARδ agonist 11
CAS:Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.Formula:C19H15F3N2O3S2Color and Shape:SolidMolecular weight:440.46Muraglitazar
CAS:Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.Formula:C29H28N2O7Purity:99.31%Color and Shape:SolidMolecular weight:516.54SP4f
SP4f, an activator of PPAR-γ, exhibits an EC50 value of 826 nM in HK-2 cells.Purity:98%Color and Shape:Odour SolidOroxin A
CAS:Oroxin A, a partial PPARγ agonist, activates PPARγ, inhibits α-glucosidase, and has antioxidant properties.Formula:C21H20O10Purity:98%Color and Shape:SolidMolecular weight:432.38Eupatilin
CAS:Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.Formula:C18H16O7Purity:98.42% - 99%Color and Shape:SolidMolecular weight:344.32Indeglitazar
CAS:Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).Formula:C19H19NO6SPurity:99.73%Color and Shape:SolidMolecular weight:389.42Magnolol
CAS:Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.Formula:C18H18O2Purity:99.49%Color and Shape:A Bioactive Compound Found In The Bark Of The Houpu MagnoliaMolecular weight:266.33L-165041
CAS:L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)Formula:C22H26O7Purity:97.97%Color and Shape:SolidMolecular weight:402.44
