Phospholipase
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic substances, playing a critical role in membrane biology and the generation of signaling molecules. Inhibitors of phospholipases are used to study their role in inflammatory diseases, cardiovascular disorders, and neurodegeneration. These inhibitors are also valuable in exploring lipid signaling pathways and their implications in disease mechanisms. At CymitQuimica, we provide a variety of phospholipase inhibitors to support your research in inflammation, lipid metabolism, and cell signaling.
Products of "Phospholipase"
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Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurity:98.47% - 99.83%Color and Shape:SolidMolecular weight:360.43Ref: TM-T4019
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg219.00€50mg350.00€100mg522.00€500mg1,130.00€1mL*10mM (DMSO)66.00€A4333
A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2.Purity:98%Color and Shape:Odour SolidSB-435495
CAS:SB-435495 is a compound characterized by its potent, selective, reversible, and non-covalent inhibition of Lp-PLA2, demonstrating an IC50 value of 0.06 nM.Formula:C38H40F4N6O2SPurity:≥98%Color and Shape:SolidMolecular weight:720.82Difluprednate
CAS:Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.Formula:C27H34F2O7Purity:99.23% - 99.86%Color and Shape:SolidMolecular weight:508.55Ref: TM-T6472
10mg39.00€25mg55.00€50mg80.00€100mg101.00€200mg177.00€500mg283.00€1mL*10mM (DMSO)48.00€Lp-PLA2-IN-14
CAS:Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.Formula:C16H14F3N3O3Purity:98%Color and Shape:SolidMolecular weight:353.3ML349
CAS:ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).Formula:C23H22N2O4S2Purity:99.59% - 99.82%Color and Shape:SolidMolecular weight:454.56FAAH/cPLA2α-IN-1
CAS:FAAH/cPLA2α-IN-1 is a compound that simultaneously inhibits both FAAH and cPLA2α, demonstrating potent activity with half-maximal inhibitory concentrations (Formula:C19H26N4O5Purity:98%Color and Shape:SolidMolecular weight:390.43ASM-IN-1
CAS:ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.Formula:C16H12BrN3O4Purity:98%Color and Shape:SolidMolecular weight:390.19A3373
CAS:A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) ofFormula:C17H9F7N2OPurity:98%Color and Shape:SoildMolecular weight:390.26CAY10650
CAS:CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).Formula:C28H25NO6Purity:95.56%Color and Shape:SolidMolecular weight:471.5Ref: TM-TQ0105
1mg51.00€5mg137.00€10mg210.00€25mg424.00€50mg628.00€100mg938.00€1mL*10mM (DMSO)140.00€VU0359595
CAS:VU0359595 (ML-270) is a selective PLD1 inhibitor with 3.7 nM IC50; >1700x more selective over PLD2, for cancer/diabetes/neurodegenerative research.Formula:C25H29BrN4O2Purity:99.15%Color and Shape:SolidMolecular weight:497.43ST271
CAS:ST271 is an effective protein tyrosine kinase (PTK) inhibitor.Formula:C16H20N2O2Purity:98.94%Color and Shape:SolidMolecular weight:272.34VU0364739
CAS:VU0364739, a selective phospholipase D2 (PLD2) inhibitor with an IC50 of 22 nM, effectively reduces cancer cell proliferation [1].Formula:C26H27FN4O2Purity:98%Color and Shape:SolidMolecular weight:446.52BMS493
CAS:BMS493 is an inverse agonist of RAR that inhibits retinoic acid-induced differentiation and inhibits the increase in phospholipase A2 activity.Formula:C29H24O2Purity:100%Color and Shape:SolidMolecular weight:404.5Varespladib methyl
CAS:Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.Formula:C22H22N2O5Purity:100% - 99.69%Color and Shape:SolidMolecular weight:394.42Ref: TM-T17218
1mg117.00€5mg283.00€10mg454.00€25mg750.00€50mg1,026.00€100mg1,406.00€500mg2,822.00€1mL*10mM (DMSO)423.00€PACOCF3
CAS:PACOCF3, a phospholipase A2 inhibitor, hinders Ca2+ signaling with an IC50 of 3.8 μM in renal cells.Formula:C17H31F3OPurity:99.57%Color and Shape:SolidMolecular weight:308.42Lp-PLA2-IN-2
CAS:Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.Formula:C19H23FN2O4SPurity:98%Color and Shape:SolidMolecular weight:394.46MAFP
CAS:MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Formula:C21H36FO2PColor and Shape:SolidMolecular weight:370.48m-3M3FBS
CAS:m-3M3FBS is a phospholipase C (PLC) activator.Formula:C16H16F3NO2SPurity:99.66%Color and Shape:SolidMolecular weight:343.36Rapanone
CAS:Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.Formula:C19H30O4Purity:99.56% - 99.56%Color and Shape:SolidMolecular weight:322.44
