GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Products of "GluR"
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FPTQ
CAS:FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].Formula:C17H12FN5Purity:99.68% - 99.88%Color and Shape:SolidMolecular weight:305.31Ref: TM-T5509
1mg50.00€2mg73.00€5mg111.00€10mg160.00€25mg310.00€50mg419.00€100mg557.00€500mgTo inquire1mL*10mM (DMSO)116.00€VU 0285683
CAS:VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.Formula:C14H7FN4OPurity:99.8%Color and Shape:SolidMolecular weight:266.23Ref: TM-T23509
1mg42.00€5mg90.00€10mg101.00€25mg170.00€50mg235.00€100mg335.00€200mg455.00€1mL*10mM (DMSO)92.00€VU6005649
CAS:VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).Formula:C16H12F5N3OPurity:99.79%Color and Shape:SolidMolecular weight:357.28Ref: TM-T13321
5mg40.00€10mg58.00€25mg105.00€50mg170.00€100mg259.00€200mg369.00€1mL*10mM (DMSO)44.00€VU-29
CAS:VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.Formula:C22H16N4O3Purity:99.63%Color and Shape:SolidMolecular weight:384.39Ref: TM-T23515
2mg34.00€5mg52.00€10mg90.00€25mg170.00€50mg273.00€100mg393.00€200mg560.00€1mL*10mM (DMSO)58.00€CBiPES hydrochloride
CAS:CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.Formula:C21H20ClN3O2SPurity:99.66%Color and Shape:SolidMolecular weight:413.92TCN238
CAS:TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).Formula:C12H11N3Purity:99.90%Color and Shape:SolidMolecular weight:197.24VU0422288
CAS:VU0422288 (ML396) is a type III mGlu receptor (mGlus) orthosteric modulator with inhibitory effects on mGluR4.VU0422288 can be used to study Rett syndrome.Formula:C17H11Cl2N3O2Purity:95.48%Color and Shape:SolidMolecular weight:360.19IEM 1754 2HBr
CAS:IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.Formula:C16H30N2·2HBrPurity:99.71% - 99.72%Color and Shape:SolidMolecular weight:412.25NS-102
CAS:NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2) and inhibits specific binding to the glur6 receptor.Formula:C12H11N3O4Purity:98.73% - 98.95%Color and Shape:SolidMolecular weight:261.23TC-N 22A
CAS:TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier.Formula:C14H13N5SPurity:99.84%Color and Shape:SolidMolecular weight:283.35ML289
CAS:ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.Formula:C22H23NO3Purity:99.09%Color and Shape:SolidMolecular weight:349.42Ref: TM-T23000
5mg50.00€10mg80.00€25mg145.00€50mg225.00€100mg339.00€200mg470.00€1mL*10mM (DMSO)51.00€AZD6538
CAS:AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.Formula:C15H6FN5OPurity:98.68%Color and Shape:SolidMolecular weight:291.24MMPIP hydrochloride
CAS:MMPIP hydrochloride is a selective antagonist of allosteric mGluR7.Formula:C19H16ClN3O3Purity:99.26%Color and Shape:SolidMolecular weight:369.8CX614
CAS:CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.Formula:C13H13NO4Purity:97.43%Color and Shape:SolidMolecular weight:247.25Ref: TM-T19698
5mg55.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€200mg409.00€1mL*10mM (DMSO)66.00€LY2794193
CAS:LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.Formula:C16H18N2O6Purity:98.15%Color and Shape:SolidMolecular weight:334.32Ro 67-4853
CAS:Ro 67-4853 is a positive allosteric modulator of mGluR1, selectively enhancing the response to the agonist (S)-3,5-dihydroxy-phenylglycine (DHPG).Formula:C19H19NO4Purity:98.57%Color and Shape:SolidMolecular weight:325.36Caroverine hydrochloride
CAS:Caroverine HCL: Blocks NMDA/AMPA receptors, antioxidant, calcium-blocker, and vasorelaxant, used for tinnitus research.Formula:C22H28ClN3O2Purity:98.37% - 98.75%Color and Shape:SolidMolecular weight:401.9Ref: TM-T9133
5mg47.00€10mg70.00€25mg131.00€50mg216.00€100mg378.00€200mg552.00€500mg868.00€1mL*10mM (DMSO)50.00€FTIDC
CAS:FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.Formula:C18H23FN6OPurity:≥98%Color and Shape:SolidMolecular weight:358.41Ref: TM-T3483
1mg105.00€2mg154.00€5mg227.00€10mg359.00€25mg597.00€50mg842.00€100mg1,130.00€1mL*10mM (DMSO)250.00€ADX-47273
CAS:ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).Formula:C20H17F2N3O2Purity:97% - 99.18%Color and Shape:SolidMolecular weight:369.36Decanoic Acid
CAS:Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist.Formula:C10H20O2Purity:98.59%Color and Shape:Crystalline Solid SolidMolecular weight:172.26
