Wnt/beta-catenin
Wnt/beta-catenin inhibitors are compounds that target and inhibit the Wnt/beta-catenin signaling pathway, which is crucial for the regulation of embryonic development, cell proliferation, and stem cell maintenance. Dysregulation of this pathway is linked to various cancers and degenerative diseases. Inhibitors of Wnt/beta-catenin signaling are valuable in research focused on understanding the role of this pathway in disease and developing targeted therapies. At CymitQuimica, we offer Wnt/beta-catenin inhibitors to support your research in stem cell biology, developmental biology, and cancer research.
Products of "Wnt/beta-catenin"
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Ipafricept
CAS:Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Color and Shape:LiquidSKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Formula:C14H14N4O3Purity:97.46% - 99.5%Color and Shape:SolidMolecular weight:286.29Ref: TM-T6989
5mg40.00€10mg60.00€25mg107.00€50mg185.00€100mg339.00€200mg510.00€500mg797.00€1mL*10mM (DMSO)66.00€KY1220
CAS:KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.Formula:C14H10N4O3SPurity:99.66%Color and Shape:SolidMolecular weight:314.32Ref: TM-T15677
2mg46.00€5mg80.00€10mg117.00€25mg259.00€50mg374.00€100mg545.00€200mg740.00€1mL*10mM (DMSO)73.00€NRX-252262
CAS:NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)Formula:C23H17Cl2F3N2O4SPurity:99.10% - 99.87%Color and Shape:SolidMolecular weight:545.36Ref: TM-T9182
1mg114.00€5mg273.00€10mg432.00€25mg715.00€50mg1,008.00€100mg1,359.00€1mL*10mM (DMSO)329.00€MSAB
CAS:MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.Formula:C15H15NO4SPurity:99.76%Color and Shape:SolidMolecular weight:305.35Ref: TM-T8710
1mg37.00€2mg49.00€5mg73.00€10mg119.00€25mg235.00€50mg354.00€100mg535.00€500mg1,121.00€1mL*10mM (DMSO)82.00€LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.Formula:C11H9ClN2O2S2Purity:99.91%Color and Shape:SolidMolecular weight:300.78DK419
CAS:DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Formula:C16H8ClF6N3OPurity:98.15%Color and Shape:SolidMolecular weight:407.7NRX-252114
CAS:NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Formula:C22H12Cl2F3N3O2SPurity:98.26%Color and Shape:SolidMolecular weight:510.32Dendrobium phenol
CAS:Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.Formula:C16H18O4Purity:98.66% - 99.48%Color and Shape:SolidMolecular weight:274.31Ref: TM-TL0008
1mg49.00€2mg65.00€5mg97.00€10mg156.00€25mg255.00€50mg373.00€100mg555.00€1mL*10mM (DMSO)165.00€Pamidronic acid
CAS:Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem CellsFormula:C3H11NO7P2Purity:97.72%Color and Shape:SolidMolecular weight:235.07Wnt pathway activator 2
CAS:Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Formula:C17H15NO4Purity:98.28%Color and Shape:SolidMolecular weight:297.31Ref: TM-T13345
1mg49.00€5mg105.00€10mg169.00€25mg344.00€50mg562.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)116.00€JW74
CAS:JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Formula:C24H20N6O2SPurity:95.00%Color and Shape:SolidMolecular weight:456.52BML-284
CAS:BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Formula:C19H18N4O3Purity:99.66% - 99.91%Color and Shape:SolidMolecular weight:350.37Ref: TM-T3144
5mg60.00€10mg88.00€25mg140.00€50mg253.00€100mg427.00€200mg615.00€500mg938.00€1mL*10mM (DMSO)66.00€WAY-262611
CAS:WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.Formula:C20H22N4Purity:98.09% - 99.09%Color and Shape:SolidMolecular weight:318.42Adavivint
CAS:Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.Formula:C29H24FN7OPurity:98.27% - 98.6%Color and Shape:SolidMolecular weight:505.55CCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Formula:C23H20BrN3OPurity:98.61%Color and Shape:SolidMolecular weight:434.33Ref: TM-T21685
1mg38.00€5mg71.00€10mg105.00€25mg207.00€50mg329.00€100mg472.00€200mg620.00€1mL*10mM (DMSO)87.00€IWP-4
CAS:IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.Formula:C23H20N4O3S3Purity:100.00%Color and Shape:SolidMolecular weight:496.62Cardiogenol C hydrochloride
CAS:Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).Formula:C13H17ClN4O2Purity:99.89% - 99.94%Color and Shape:SolidMolecular weight:296.75TNIK-IN-7
CAS:TNIK-IN-7 is a Traf2 and Nck interacting kinase (TNIK) inhibitor with antitumor activity for the study of signaling and proliferation in colorectal cancer cellsFormula:C23H22N4O2Purity:99.87%Color and Shape:SoildMolecular weight:386.45Tankyrase-IN-2
CAS:Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectivelyFormula:C17H14F2N2O2Purity:98%Color and Shape:SolidMolecular weight:316.3BML-286
CAS:BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.Formula:C22H18N2O4Color and Shape:SolidMolecular weight:374.39Carboxylesterase-IN-2
CAS:Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.Formula:C13H12N4OSPurity:100%Color and Shape:SoildMolecular weight:272.33Ref: TM-T77524
1mg62.00€5mg140.00€10mg215.00€25mg369.00€50mg509.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)156.00€IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formula:C26H20N6OPurity:99.12%Color and Shape:SolidMolecular weight:432.48Ref: TM-T5342
2mg39.00€5mg64.00€10mg101.00€25mg163.00€50mg226.00€100mg320.00€200mg459.00€1mL*10mM (DMSO)70.00€Wnt pathway inhibitor 3
CAS:Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studiesFormula:C21H17BrN2O5Purity:99.69%Color and Shape:SoildMolecular weight:457.27NRX-103095
CAS:NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Formula:C22H16Cl2F3N3O3SPurity:99.16% - 99.60%Color and Shape:SolidMolecular weight:530.35Ref: TM-T63730
1mg150.00€5mg364.00€10mg588.00€25mg1,169.00€50mg1,882.00€100mg2,822.00€1mL*10mM (DMSO)426.00€KY-05009
CAS:KY-05009 blocks TGF-β1 EMT in lung cancer cells, inhibits TNIK, Wnt genes, induces apoptosis, and is an ATP-competitive TNIK inhibitor (Ki = 100 nM).Formula:C18H16N4O2SPurity:98.06%Color and Shape:SolidMolecular weight:352.41Ref: TM-T11793
5mg50.00€10mg71.00€25mg117.00€50mg170.00€100mg245.00€200mg354.00€1mL*10mM (DMSO)51.00€CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Formula:C23H24ClN5OPurity:98.2% - 98.69%Color and Shape:SolidMolecular weight:421.92β-catenin modulator IIa-661
CAS:β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Formula:C19H23ClN2O3SPurity:99.53%Color and Shape:SoildMolecular weight:394.92ETC-159
CAS:ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.Formula:C19H17N7O3Purity:96.87% - 99.30%Color and Shape:SolidMolecular weight:391.38Wnt pathway activator 1
CAS:Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.Formula:C18H16O4Purity:99.94%Color and Shape:SolidMolecular weight:296.32Ref: TM-T17256
2mg34.00€5mg52.00€10mg80.00€25mg131.00€50mg212.00€100mg316.00€200mg454.00€1mL*10mM (DMSO)52.00€Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Purity:>95% - >95%Color and Shape:Liquid
