Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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p62-ZZ Ligand-Linker Conjugate 1
CAS:p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.Formula:C31H42N2O6Color and Shape:SolidMolecular weight:538.68Ciclopirox
CAS:Ciclopirox is an antifungal that chelates Fe3+ and Al3+, inhibiting enzymes and has antibacterial and anti-inflammatory effects.Formula:C12H17NO2Purity:97.72% - 99.41%Color and Shape:SolidMolecular weight:207.27Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Formula:C17H17N7Purity:98.39% - 98.43%Color and Shape:SolidMolecular weight:319.36Ref: TM-T6945
1mg51.00€2mg71.00€5mg116.00€10mg202.00€25mg454.00€50mg663.00€100mg944.00€500mg1,890.00€1mL*10mM (DMSO)116.00€Nitrendipine
CAS:Nitrendipine is a vasodilating calcium channel blocker and antihypertensive that preserves kidney function and promotes sodium excretion.Formula:C18H20N2O6Purity:99.54% - 99.55%Color and Shape:SolidMolecular weight:360.36Ref: TM-T0119
1g437.00€10mg38.00€25mg55.00€50mg71.00€100mg119.00€200mg175.00€500mg283.00€1mL*10mM (DMSO)55.00€HA15
CAS:HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.Formula:C23H22N4O3S2Purity:99.77% - 99.86%Color and Shape:SolidMolecular weight:466.58Ref: TM-T6855
1mg40.00€2mg51.00€5mg84.00€10mg96.00€25mg187.00€50mg329.00€100mg567.00€1mL*10mM (DMSO)84.00€Veliparib dihydrochloride
CAS:Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formula:C13H18Cl2N4OPurity:97.09% - 98%Color and Shape:SolidMolecular weight:317.21Danshensu sodium salt
CAS:Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen.Formula:C9H9NaO5Purity:97.04% - 99.52%Color and Shape:SolidMolecular weight:220.16LRRK2 inhibitor 1
CAS:LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.Formula:C20H23N5O4Purity:99.73%Color and Shape:SolidMolecular weight:397.43Ref: TM-T11878
1mg74.00€2mg97.00€5mg160.00€10mg264.00€25mg557.00€50mg944.00€100mg1,491.00€1mL*10mM (DMSO)170.00€Chloroquine phosphate
CAS:Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is used as an autophagy inhibitor. Chloroquine also is an inhibitor of TLRs.Formula:C18H26CLN3·2(H3PO4)Purity:99.64% - ≥95%Color and Shape:White To Slightly Yellow Crystalline Powder White SolidMolecular weight:515.87SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurity:98.84%Color and Shape:SolidMolecular weight:469.56Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Formula:C17H19NO5Purity:97.03% - 99.89%Color and Shape:SolidMolecular weight:317.34Andrographolide
CAS:Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potentialFormula:C20H30O5Purity:100% - 99.97%Color and Shape:PowderMolecular weight:350.45L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurity:≥95%Color and Shape:SolidMolecular weight:347.86-Thioguanine
CAS:6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formula:C5H5N5SPurity:100% - 98.75%Color and Shape:Odorless Or Almost Odorless Pale Yellow Crystalline PowderMolecular weight:167.19Quisinostat dihydrochloride
CAS:Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性,高效的 pan-HDAC 抑制剂,具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。Formula:C21H28Cl2N6O2Purity:97.13%Color and Shape:SolidMolecular weight:467.39Zebularine
CAS:Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Formula:C9H12N2O5Purity:100% - 99.84%Color and Shape:SolidMolecular weight:228.2Everolimus
CAS:Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.Formula:C53H83NO14Purity:97.76% - 99.52%Color and Shape:Off-White To Light Yellow PowdMolecular weight:958.22Ref: TM-T1784
5mg44.00€10mg55.00€25mg82.00€50mg96.00€100mg120.00€200mg177.00€500mg298.00€1mL*10mM (DMSO)55.00€Sodium salicylate
CAS:Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Formula:C7H5NaO3Purity:99.36% - 99.77%Color and Shape:White Solid AmorphousMolecular weight:160.11Cilofexor
CAS:Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Formula:C28H22Cl3N3O5Purity:99.32% - ≥95%Color and Shape:SolidMolecular weight:586.85Ref: TM-T7436
1mg50.00€2mg73.00€5mg124.00€10mg188.00€25mg380.00€50mg567.00€100mg807.00€500mg1,644.00€1mL*10mM (DMSO)158.00€Rosolutamide
CAS:Rosolutamide (ALZ-003) is a curcumin analog, an Nrf1 and Nrf2 activator.Formula:C28H32O6Purity:96.54% - 99.36%Color and Shape:SolidMolecular weight:464.55
