Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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VISTA-IN-2
CAS:VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,Formula:C23H23N3OPurity:98%Color and Shape:SolidMolecular weight:357.45Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurity:98% - 99.75%Color and Shape:SolidMolecular weight:393.49Ref: TM-T1825
1mg38.00€2mg49.00€5mg70.00€10mg88.00€25mg164.00€50mg224.00€100mg393.00€1mL*10mM (DMSO)70.00€TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Formula:C20H12F3N3Purity:98.77% - 99.94%Color and Shape:SolidMolecular weight:351.32Ref: TM-T4645
2mg35.00€5mg52.00€10mg85.00€25mg156.00€50mg235.00€100mg329.00€200mg464.00€1mL*10mM (DMSO)71.00€10074-G5
CAS:10074-G5 is an inhibitor of c-Myc-Max dimerization.Formula:C18H12N4O3Purity:97.22% - 99.67%Color and Shape:SolidMolecular weight:332.31Ref: TM-T3686
2mg42.00€5mg63.00€10mg88.00€25mg142.00€50mg225.00€100mg396.00€200mg565.00€500mg900.00€1mL*10mM (DMSO)69.00€Temozolomide
CAS:Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity.Formula:C6H6N6O2Purity:98% - 99.87%Color and Shape:Off-White To Light-Pink Crystalline SolidMolecular weight:194.15Ref: TM-T1178
1g236.00€10mg49.00€25mg74.00€50mg89.00€100mg96.00€200mg127.00€500mg166.00€1mL*10mM (DMSO)59.00€Neferine
CAS:Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.Formula:C38H44N2O6Purity:98.81% - 99.18%Color and Shape:SolidMolecular weight:624.77Metyrapone
CAS:Metyrapone (NSC-25265) blocks steroid 11β-monooxygenase, used to diagnose Cushing's syndrome.Formula:C14H14N2OPurity:99.03% - ≥95%Color and Shape:Crystals From Ether & Pentane SolidMolecular weight:226.27Afzelin
CAS:Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-Formula:C21H20O10Purity:98.92% - 99.38%Color and Shape:SolidMolecular weight:432.38DCC-3116
CAS:DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.Formula:C26H36F3N7O2Purity:98.80%Color and Shape:SoildMolecular weight:535.61Autocamtide-2-related inhibitory peptide
CAS:Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.Formula:C64H116N22O19Purity:100%Color and Shape:SolidMolecular weight:1497.74Nitroxoline
CAS:Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found inFormula:C9H6N2O3Purity:97.74% - ≥98%Color and Shape:SolidMolecular weight:190.16Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Formula:C20H15Cl3N2OS·HNO3Purity:98.66%Color and Shape:SolidMolecular weight:500.78Silmitasertib
CAS:Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).Formula:C19H12ClN3O2Purity:98% - 99.90%Color and Shape:SolidMolecular weight:349.77Ref: TM-T2259
1mg40.00€2mg51.00€5mg85.00€10mg125.00€25mg207.00€50mg329.00€100mg520.00€500mg1,111.00€1mL*10mM (DMSO)93.00€Necrostatin-1
CAS:Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity.Formula:C13H13N3OSPurity:100% - 99.81%Color and Shape:SolidMolecular weight:259.33Ref: TM-T1847
5mg35.00€10mg49.00€25mg82.00€50mg113.00€100mg170.00€200mg250.00€500mg419.00€1mL*10mM (DMSO)52.00€Scutellarein
CAS:Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.Formula:C15H10O6Purity:98.02% - 99.63%Color and Shape:SolidMolecular weight:286.24LY2183240
CAS:LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM).Formula:C17H17N5OPurity:99.26%Color and Shape:SolidMolecular weight:307.35PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formula:C27H31NO4SPurity:99.02%Color and Shape:SolidMolecular weight:465.6Ref: TM-T6085
1mg50.00€5mg106.00€10mg156.00€25mg251.00€50mg374.00€100mg557.00€200mg903.00€1mL*10mM (DMSO)124.00€Lumacaftor
CAS:Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Formula:C24H18F2N2O5Purity:99.48% - 99.68%Color and Shape:SolidMolecular weight:452.41D4476
CAS:D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).Formula:C23H18N4O3Purity:99.02% - 99.96%Color and Shape:SolidMolecular weight:398.41Ref: TM-T2449
1mg43.00€2mg55.00€5mg78.00€10mg95.00€25mg159.00€50mg226.00€100mg408.00€200mg597.00€500mg938.00€1mL*10mM (DMSO)86.00€Pennogenin 3-O-β-chacotrioside
CAS:Pennogenin 3-O-beta-chacotrioside from Paris polyphylla fights colorectal cancer, boosting autophagy proteins LC3 and Beclin-1.Formula:C45H72O17Purity:99.69% - 99.77%Color and Shape:SolidMolecular weight:885.04
