DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Products of "DUB"
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C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Formula:C17H8FNO3Purity:97.22%Color and Shape:SolidMolecular weight:293.25IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formula:C20H23N3O2Purity:99.30%Color and Shape:SolidMolecular weight:337.42Ref: TM-T9375
1mg49.00€5mg104.00€10mg169.00€25mg334.00€50mg472.00€100mg658.00€200mg930.00€1mL*10mM (DMSO)115.00€GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Formula:C20H20N4O2Purity:96.59% - 98.2%Color and Shape:SolidMolecular weight:348.4Ref: TM-T4634
1mg81.00€5mg170.00€10mg273.00€25mg525.00€50mg753.00€100mg1,026.00€1mL*10mM (DMSO)187.00€USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Formula:C22H23N3O3Purity:99.35% - 99.81%Color and Shape:SolidMolecular weight:377.44SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Formula:C17H9NO3Purity:98.44%Color and Shape:SolidMolecular weight:275.26USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formula:C22H18N4Purity:98.2%Color and Shape:SolidMolecular weight:338.41VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formula:C23H17F2N3O6Purity:98.53% - 99.91%Color and Shape:SolidMolecular weight:469.39Ref: TM-T4067
1mg96.00€2mg155.00€5mg259.00€10mg406.00€25mg680.00€50mg938.00€100mg1,301.00€1mL*10mM (DMSO)265.00€IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。Formula:C19H23ClN2OPurity:98.94%Color and Shape:SolidMolecular weight:330.85Ref: TM-T15604
1mg35.00€5mg74.00€10mg127.00€25mg263.00€50mg467.00€100mg785.00€200mg1,074.00€1mL*10mM (DMSO)81.00€USP8-IN-1
CAS:USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Formula:C18H21N5O3SPurity:98.01%Color and Shape:SoildMolecular weight:387.46Ref: TM-T60146
1mg88.00€5mg187.00€10mg264.00€25mg464.00€50mg655.00€100mg944.00€1mL*10mM (DMSO)207.00€USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formula:C23H24ClN3O3Purity:98.70%Color and Shape:SolidMolecular weight:425.91Ref: TM-T13268
1mg97.00€5mg188.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)217.00€IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formula:C23H19N5OPurity:99.77%Color and Shape:SolidMolecular weight:381.43Wu-5
CAS:Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.Formula:C15H13NO7SPurity:99.29%Color and Shape:SoildMolecular weight:351.33OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Formula:C19H18N2O6S2Purity:98.19%Color and Shape:SolidMolecular weight:434.49USP1-IN-2
CAS:USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Formula:C26H22F4N6OPurity:99.60% - 99.88%Color and Shape:SolidMolecular weight:510.486XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Formula:C48H57ClN8O5Purity:98.75%Color and Shape:SolidMolecular weight:861.47Ref: TM-T9122
1mg96.00€5mg187.00€10mg298.00€25mg507.00€50mg730.00€100mg1,026.00€1mL*10mM (DMSO)283.00€HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Formula:C25H28ClN3OPurity:98.76%Color and Shape:SolidMolecular weight:421.96Ref: TM-T15464
1mg38.00€5mg85.00€10mg117.00€25mg187.00€50mg266.00€100mg373.00€200mg530.00€1mL*10mM (DMSO)94.00€DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Formula:C15H9N5OPurity:98.96%Color and Shape:SolidMolecular weight:275.26Ref: TM-T11111
1mg79.00€5mg172.00€10mg259.00€25mg518.00€50mg758.00€100mg1,103.00€200mg1,483.00€1mL*10mM (DMSO)182.00€P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formula:C12H7F2NO3S2Purity:97.9% - 99.58%Color and Shape:SolidMolecular weight:315.32USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C23H20Cl2N2O3SPurity:99.85%Color and Shape:SolidMolecular weight:475.39USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.Formula:C19H20ClN3O5SPurity:99.53%Color and Shape:SoildMolecular weight:437.9
