Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors that mediate the effects of endogenous and exogenous opioids. These receptors play a central role in pain modulation, mood regulation, and addictive behaviors. Opioid receptor agonists and antagonists are extensively used in pain management and addiction treatment, as well as in research on neurological and psychiatric disorders. At CymitQuimica, we provide a comprehensive selection of high-quality opioid receptor modulators to support your research in neurobiology, pain management, and addiction therapy.
Products of "Opioid Receptor"
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BW-180C
CAS:BW-180C (DADLE) is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.Formula:C29H39N5O7Purity:100%Color and Shape:SolidMolecular weight:569.65Ref: TM-TP1905
1mg47.00€2mg62.00€5mg89.00€10mg139.00€25mg254.00€50mg400.00€100mg595.00€1mL*10mM (DMSO)111.00€BMS-986122
CAS:BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1Formula:C16H15BrClNO3S2Purity:98.42%Color and Shape:SolidMolecular weight:448.78Ref: TM-T26869
1mg48.00€5mg96.00€10mg160.00€25mg344.00€50mg550.00€100mg787.00€500mg1,568.00€1mL*10mM (DMSO)96.00€Endomorphin 2
CAS:EM-2 reduces sEPSC frequency/amplitude in lamina IX motoneurons; CTOP reverses this. EM-2-IR affects limb muscles via presynaptic/postsynaptic mechanisms.Formula:C32H37N5O5Purity:99.64%Color and Shape:SolidMolecular weight:571.67MOR agonist-2
Compound 46, designated as MOR agonist-2, serves as a D3R antagonist and a MOR agonist with respective K i values of 7.26 nM and 564 nM.Formula:C37H47Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:680.71Asimadoline
CAS:Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany.Formula:C27H30N2O2Color and Shape:SolidMolecular weight:414.54Urotensin-II receptor antagonist-1
CAS:Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM).Formula:C25H31Cl2N3OColor and Shape:SolidMolecular weight:460.439ICI 204,448
CAS:ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.Formula:C23H27Cl3N2O4Purity:100%Color and Shape:SolidMolecular weight:501.83Opioid receptor agonist 1
Opioid receptor agonist1 (Compound 2638-28) is an orally active opioid receptor agonist that shows strong affinity for MOR, DOR, and KOR, with Ki values of 5, 24, and 212 nM, respectively. It exhibits analgesic activity in both the mouse warm water tail-flick model and the acetic acid writhing model.Formula:C32H45N5OMolecular weight:515.73LY255582
CAS:LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM,Formula:C22H35NO2Purity:98%Color and Shape:SolidMolecular weight:345.526'-GNTI dihydrochloride
CAS:6'-GNTI dihydrochloride is a κ-opioid receptor (KOR) agonist that favors activation of G-protein-mediated signaling over recruitment of β-aspirin 2.Formula:C27H29N5O3·2ClHPurity:99.08%Color and Shape:SolidMolecular weight:544.47IPAG
CAS:IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.Formula:C17H22IN3Purity:98.8%Color and Shape:SolidMolecular weight:395.28SNC 80
CAS:SNC 80, a non-peptide δ-opioid agonist (Ki=1.78 nM, IC50=2.73 nM), also targets μ-δ heteromers (EC50=52.8 nM), with analgesic and antidepressant potential.Formula:C28H39N3O2Purity:98.67%Color and Shape:SolidMolecular weight:449.63Anilopam
CAS:Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at opioid receptors.Formula:C20H26N2OColor and Shape:SolidMolecular weight:310.43Cebranopadol
CAS:Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP)Formula:C24H27FN2OPurity:99.61% - 99.78%Color and Shape:SolidMolecular weight:378.48Ref: TM-T5167
2mg40.00€5mg60.00€10mg87.00€25mg170.00€50mg274.00€100mg406.00€200mg592.00€1mL*10mM (DMSO)66.00€KOR agonist 3
KOR agonist 3 (Compound 5) is an agonist of the κ opioid receptor (κOR) with an EC50 of 0.88 nM. It also exhibits some activation of μOR, with an EC50 of 720 nM. However, KOR agonist 3 does not activate δOR at concentrations below 1 μM. Its ability to recruit β-Arrestin-2 is lower than that of U50488.Formula:C24H24N2O3Color and Shape:SolidMolecular weight:388.46LY2444296
CAS:LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).Formula:C24H22F2N2O2Purity:98.03%Color and Shape:SolidMolecular weight:408.44AH 8529
CAS:AH 8529 is an orally active opioid compound with analgesic properties.Formula:C16H23ClN2OColor and Shape:SolidMolecular weight:294.82Samidorphan HCl
CAS:Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ-opioid, κ-opioid, and delta-opioid receptors.Formula:C21H27ClN2O4Purity:98.25% - 99.60%Color and Shape:SoildMolecular weight:406.9DuP 747 HCl
CAS:DuP 747 HCl is a selective kappa agonist with analgesic activity.DuP 747 consists of two conformations.Formula:C24H29Cl3N2O2Purity:99.81%Color and Shape:SoildMolecular weight:483.86NNC 63-0532
CAS:NNC 63-0532 is a potentnociceptin receptor agonist, Ki=7.3 nM, EC50=305 nM.Formula:C27H29N3O3Purity:98.75%Color and Shape:SolidMolecular weight:443.54
