PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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CHMFL-PI3KD-317
CAS:CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.Formula:C21H24ClN5O3S2Purity:97.8%Color and Shape:SolidMolecular weight:494.03Ref: TM-T10804
1mg92.00€5mg216.00€10mg329.00€25mg593.00€50mg893.00€100mg1,216.00€1mL*10mM (DMSO)235.00€5-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormula:C16H10IN3O2Color and Shape:SolidMolecular weight:403.17EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Color and Shape:Odour SolidPI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Formula:C22H25N3O5S2Purity:99.76%Color and Shape:SolidMolecular weight:475.58Ref: TM-T12468
1mg80.00€5mg164.00€10mg255.00€25mg420.00€50mg562.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)167.00€BI-4020
CAS:BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.Formula:C30H38N8O2Purity:100.00% - 98.44%Color and Shape:SolidMolecular weight:542.68Ref: TM-T10534
1mg170.00€5mg398.00€10mg568.00€25mg848.00€50mg1,130.00€100mg1,510.00€200mg2,062.00€1mL*10mM (DMSO)472.00€Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurity:98.01% - 99.36%Color and Shape:SolidMolecular weight:270.29Ref: TM-T7014
1mg38.00€2mg49.00€5mg79.00€10mg124.00€25mg240.00€50mg384.00€100mg560.00€1mL*10mM (DMSO)79.00€CGP77675
CAS:CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFormula:C26H29N5O2Purity:98.23%Color and Shape:SolidMolecular weight:443.54Dalmitamig
Dalmitamig is a humanized IgG4κ antibody targeting EGFR/CD28, with HumanIgG4(S228P) kappa as its corresponding isotype control.Color and Shape:Odour LiquidEGFR/CDK2-IN-3
EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively.Formula:C30H20N6OSPurity:98%Color and Shape:SolidMolecular weight:512.58YM-53601 free base
CAS:YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.Formula:C21H21FN2OPurity:98%Color and Shape:SolidMolecular weight:336.4CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Formula:C15H19N7O3SPurity:98.81% - 99.87%Color and Shape:SolidMolecular weight:377.42Ref: TM-T2619
1mg64.00€2mg96.00€5mg144.00€10mg227.00€25mg420.00€50mg622.00€100mg885.00€500mg1,786.00€GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.Formula:C9H6BrNOPurity:99.58%Color and Shape:Off-White To Light Yellow Crystalline PowderMolecular weight:224.05Rilematovir
CAS:Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.Formula:C21H20ClF3N4O3SPurity:99.82%Color and Shape:SolidMolecular weight:500.92EGFR-IN-133
CAS:EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.Formula:C27H29F2N7O3Color and Shape:SolidMolecular weight:537.56P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFormula:C9H8ClN3OPurity:99.95%Color and Shape:SolidMolecular weight:209.63Khellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Formula:C14H12O5Purity:99.85% - 99.95%Color and Shape:Light Yellow CrystallineMolecular weight:260.24TWS119
CAS:TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiationFormula:C18H14N4O2Purity:98.02% - 99.13%Color and Shape:SolidMolecular weight:318.331-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Formula:C15H10BrN3OPurity:99.6%Color and Shape:Tan SolidMolecular weight:328.16Ref: TM-T6358
1mg79.00€2mg99.00€5mg188.00€10mg311.00€25mg560.00€50mg800.00€100mg1,093.00€500mg2,175.00€1mL*10mM (DMSO)187.00€MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Formula:C17H21N7O4Purity:100% - 99.6%Color and Shape:SolidMolecular weight:387.39Depatuxizumab
CAS:Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograftPurity:98%Color and Shape:Liquid
