PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
Show 2 more subcategories
Products of "PI3K/Akt/mTOR Signaling"
Sort by
BRD5648
CAS:BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Formula:C20H23N3OPurity:99.37%Color and Shape:SolidMolecular weight:321.42LY-294002 hydrochloride
CAS:LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.Formula:C19H17NO3·HClPurity:99.95%Color and Shape:SolidMolecular weight:343.81MIPS-21335
CAS:MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ withFormula:C24H21N7O5Purity:98%Color and Shape:SolidMolecular weight:487.47GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Formula:C19H22N6O3SPurity:98.42% - 99.42%Color and Shape:SolidMolecular weight:414.48Ref: TM-T6845
1mg39.00€2mg51.00€5mg84.00€10mg119.00€25mg210.00€50mg349.00€100mg434.00€200mg635.00€1mL*10mM (DMSO)92.00€GSK-3 inhibitor 4
CAS:Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.Formula:C22H15F2N5OPurity:98.77%Color and Shape:SoildMolecular weight:403.38Ref: TM-T77341
1mg333.00€5mg922.00€10mg1,140.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg3,734.00€Necitumumab
Necitumumab (IMC-11F8) is a human monoclonal antibody against EGFR, an anti-angiogenic agent used in the treatment of advanced non-small cell lung cancer.Color and Shape:LiquidMolecular weight:145.5 kDaParsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)Formula:C20H22ClFN6O2Purity:98.59%Color and Shape:SolidMolecular weight:432.88Ref: TM-T12367
1mg145.00€5mg305.00€10mg495.00€25mg805.00€50mg1,111.00€100mg1,501.00€1mL*10mM (DMSO)335.00€Desmethyl Erlotinib hydrochloride
CAS:Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.Formula:C21H21N3O4·HClPurity:99.49%Color and Shape:SolidMolecular weight:415.87Ref: TM-T6619
1mg59.00€2mg84.00€5mg115.00€10mg188.00€25mg335.00€50mg505.00€100mg720.00€1mL*10mM (DMSO)127.00€PROTAC EGFR degrader 8
CAS:PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells.Formula:C40H46ClN11O5Purity:98%Color and Shape:SolidMolecular weight:796.32Chrysophanol
CAS:Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.Formula:C15H10O4Purity:97.91% - 99.7%Color and Shape:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMolecular weight:254.24GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44GSK-3β inhibitor 22
CAS:GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.Formula:C18H12F3N3O2S2Color and Shape:SolidMolecular weight:423.43EGFR ligand-11
CAS:EGF Rligand-11, a target protein ligand for EGFR, is utilized in the synthesis of PROTAC MS154.Formula:C25H29ClFN5O4Color and Shape:SolidMolecular weight:517.98GSK-3 Inhibitor XIII
CAS:GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Formula:C18H15N5Purity:100% - 98.57%Color and Shape:SolidMolecular weight:301.35CUDC-101
CAS:CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.Formula:C24H26N4O4Purity:95.76% - 99.17%Color and Shape:SolidMolecular weight:434.49mTOR inhibitor-14
mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1Purity:98%Color and Shape:Odour SolidTucatinib
CAS:Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).Formula:C26H24N8O2Purity:99.05% - 99.96%Color and Shape:SolidMolecular weight:480.52Ref: TM-T2364
1g1,130.00€2mg35.00€5mg49.00€10mg79.00€25mg124.00€50mg187.00€100mg350.00€500mg825.00€1mL*10mM (DMSO)87.00€
