PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
Show 2 more subcategories
Products of "PI3K/Akt/mTOR Signaling"
Sort by
Neratinib maleate
CAS:Neratinib maleate is a selective HER2/EGFR inhibitor (IC50: 59/92 nM) used in breast and prostate cancer studies.Formula:C34H33ClN6O7Purity:99.64%Color and Shape:SolidMolecular weight:673.11Falnidamol
CAS:Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formula:C18H19ClFN7Purity:96.46%Color and Shape:SolidMolecular weight:387.84Ref: TM-TQ0271
2mg42.00€5mg64.00€10mg101.00€25mg192.00€50mg335.00€100mg462.00€200mg645.00€1mL*10mM (DMSO)64.00€PI3Kγ ligand 1
CAS:PI3Kγ ligand 1 serves as a PROTAC target protein ligand (Ligand for Target Protein for PROTAC).Formula:C26H29N5O3SColor and Shape:SolidMolecular weight:491.61ALK-IN-1
CAS:ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.Formula:C26H34ClN6O2PPurity:99.74% - 99.80%Color and Shape:SolidMolecular weight:529.01Canertinib
CAS:Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.Formula:C24H25ClFN5O3Purity:100% - 99.18%Color and Shape:White Or Similar To White Crystalline PowderMolecular weight:485.94AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H31N7O2Purity:97.07%Color and Shape:SolidMolecular weight:485.58JTV-519 hemifumarate
CAS:JTV-519 hemifumarate: Ca2+ blocker, SERCA inhibitor, ryanodine receptor partial agonist; antiarrhythmic, cardioprotective.Formula:C54H68N4O8S2Purity:98%Color and Shape:SolidMolecular weight:965.28Osu03012
CAS:Osu03012 (AR-12): oral celecoxib-derived PDK1 inhibitor with anticancer potential.Formula:C26H19F3N4OPurity:97.95% - 99.22%Color and Shape:SolidMolecular weight:460.45Ref: TM-T2466
2mg37.00€5mg51.00€10mg87.00€25mg143.00€50mg264.00€100mg349.00€200mg454.00€500mg742.00€1mL*10mM (DMSO)51.00€TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Formula:C21H32O6Purity:98.08%Color and Shape:SolidMolecular weight:380.48Ref: TM-T13173
1mg80.00€5mg167.00€10mg274.00€25mg465.00€50mg655.00€100mg1,017.00€1mL*10mM (DMSO)170.00€TX2-120-1
CAS:TX2-120-1 possesses the ability to bind with Her3, exhibiting an IC50 of 56 nM for Her3. It can be utilized in the synthesis of TX2-121-1.Formula:C26H27N7O2Color and Shape:SolidMolecular weight:469.54EGFR-IN-73
CAS:EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formula:C19H17ClFN3O4Purity:98%Color and Shape:SolidMolecular weight:405.81WHI-P258
CAS:WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.Formula:C16H15N3O2Purity:99.64% - 99.95%Color and Shape:SolidMolecular weight:281.31A 1070722
CAS:A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.Formula:C17H13F3N4O2Purity:99.78%Color and Shape:SolidMolecular weight:362.31UCL-TRO-1938
CAS:UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects.Formula:C27H32N6OPurity:99.95%Color and Shape:SolidMolecular weight:456.58Ref: TM-T78092
5mg120.00€10mg187.00€25mg393.00€50mg628.00€100mg1,008.00€200mg1,349.00€1mL*10mM (DMSO)120.00€EGFR-IN-81
EGFR-IN-81 (Compound 10i), an EGFR inhibitor, demonstrates potent activity by inhibiting EGFR WT and the L858R/T790M mutation at IC50 values of 4.38 nM and 5.69Formula:C28H24F3N5O4Purity:98%Color and Shape:SolidMolecular weight:551.52Poziotinib hydrochloride
CAS:Oral poziotinib HCl targets EGFR/HER mutants, inhibiting cancer cell growth.Formula:C23H22Cl3FN4O3Purity:97.48% - 99.81%Color and Shape:SolidMolecular weight:527.8Ref: TM-T8758
5mg55.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€200mg409.00€500mg677.00€1mL*10mM (DMSO)88.00€Metformin-d6 hydrochloride
CAS:Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.Formula:C4H12ClN5Purity:98.1%Color and Shape:SolidMolecular weight:171.66CNX-1351
CAS:CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.Formula:C30H35N7O3SPurity:98.83% - 99.69%Color and Shape:SolidMolecular weight:573.71GSK-3β inhibitor 11
CAS:GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.Formula:C20H15N3O4SPurity:97.33%Color and Shape:SolidMolecular weight:393.42NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Formula:C18H20N8O2Purity:97.79%Color and Shape:SolidMolecular weight:380.4
