PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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TGX-221
CAS:TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.Formula:C21H24N4O2Purity:100% - 99.8%Color and Shape:SolidMolecular weight:364.44Ref: TM-T2661
1mg38.00€2mg49.00€5mg74.00€10mg116.00€25mg217.00€50mg359.00€100mg560.00€500mg1,198.00€1mL*10mM (DMSO)81.00€SST0116CL1
CAS:SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.Formula:C22H31ClN4O6Color and Shape:SolidMolecular weight:482.96Canertinib dihydrochloride
CAS:Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic andFormula:C24H27Cl3FN5O3Purity:99.13% - 99.23%Color and Shape:SolidMolecular weight:558.86Linperlisib
CAS:Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3KδFormula:C28H37FN6O5SPurity:99.01%Color and Shape:SolidMolecular weight:588.69Ref: TM-T6330
1mg35.00€2mg48.00€5mg70.00€10mg96.00€25mg202.00€50mg311.00€100mg487.00€1mL*10mM (DMSO)92.00€Duvelisib
CAS:Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.Formula:C22H17ClN6OPurity:99.38% - 99.74%Color and Shape:SolidMolecular weight:416.8620(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formula:C42H72O13Purity:100% - 99.93%Color and Shape:SolidMolecular weight:785.01SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Formula:C19H21ClF3N5O2Purity:99.42% - 99.79%Color and Shape:SolidMolecular weight:443.85Ref: TM-T12831L
1mg149.00€2mg217.00€5mg368.00€10mg580.00€25mg882.00€50mg1,596.00€1mL*10mM (DMSO)444.00€Insecticidal agent 364
CAS:Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.Formula:C23H18N4O3SPurity:98.24%Color and Shape:SolidMolecular weight:430.48GSK-3β inhibitor 8
CAS:GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidineFormula:C20H20ClN5OSPurity:98%Color and Shape:SolidMolecular weight:413.92PF-06459988
CAS:PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.Formula:C19H22ClN7O3Purity:98%Color and Shape:SolidMolecular weight:431.88Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Formula:C22H18FN7OPurity:98% - 99.39%Color and Shape:SolidMolecular weight:415.42Ref: TM-T1894
5mg35.00€10mg50.00€25mg74.00€50mg93.00€100mg108.00€200mg140.00€500mg225.00€1mL*10mM (DMSO)52.00€Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Formula:C21H24ClN7OPurity:97.04%Color and Shape:SolidMolecular weight:425.91Ref: TM-T7015
1mg46.00€2mg59.00€5mg93.00€10mg131.00€25mg219.00€50mg350.00€100mg505.00€1mL*10mM (DMSO)92.00€CP21R7
CAS:CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.Formula:C19H15N3O2Purity:96.14% - 98.21%Color and Shape:SolidMolecular weight:317.34Ref: TM-T3684
1mg63.00€2mg86.00€5mg97.00€10mg155.00€25mg273.00€50mg462.00€100mg677.00€1mL*10mM (DMSO)81.00€PI3Kδ-IN-14
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain ofFormula:C26H20ClFN8OPurity:98%Color and Shape:SolidMolecular weight:514.94DS06652923
DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.Color and Shape:Odour SolidErlotinib hydrochloride
CAS:Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Formula:C22H23N3O4·HClPurity:99.78% - 99.85%Color and Shape:White Or Off-White PowderMolecular weight:429.9β-Hydroxyisovalerylshikonin
CAS:Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumorFormula:C21H24O7Purity:98.16%Color and Shape:SolidMolecular weight:388.41Cavutilide
CAS:Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.Formula:C22H26FN3O3Purity:99.26% - 99.70%Color and Shape:SolidMolecular weight:399.458UCB9608
CAS:UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.Formula:C20H26N8O2Purity:98.65% - 99.59%Color and Shape:SolidMolecular weight:410.47Ref: TM-TQ0009
1mg55.00€5mg117.00€10mg170.00€25mg276.00€50mg395.00€100mg562.00€200mg758.00€1mL*10mM (DMSO)128.00€Disitamab vedotin
CAS:Disitamab vedotin (RC-48) is a HER2-targeting ADC with MMAE, effective in HER2-expressing gastric cancer.Purity:95.00% - 98%Color and Shape:LiquidMolecular weight:Approximately 144.15 kDa
