PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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ES-072
CAS:ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.Formula:C25H27F3N8O2Color and Shape:SolidMolecular weight:528.53ZLN024
CAS:ZLN024 is an activator of AMPK allosteric.Formula:C13H13BrN2OSPurity:99.82%Color and Shape:SolidMolecular weight:325.22Ref: TM-T13411
1mg87.00€5mg187.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)188.00€JCN037
CAS:JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Formula:C16H11BrFN3O2Purity:99.50%Color and Shape:SolidMolecular weight:376.18Ref: TM-T8431
2mg40.00€5mg74.00€10mg105.00€25mg178.00€50mg273.00€100mg391.00€200mg557.00€1mL*10mM (DMSO)84.00€BQR-695
CAS:BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.Formula:C19H20N4O3Purity:98.91% - 99.69%Color and Shape:SolidMolecular weight:352.39WZ-3146
CAS:WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).Formula:C24H25ClN6O2Purity:97.15%Color and Shape:SolidMolecular weight:464.95Ref: TM-T6733
1mg52.00€2mg74.00€5mg97.00€10mg180.00€25mg319.00€50mg510.00€100mg730.00€1mL*10mM (DMSO)106.00€EGFR-IN-123
CAS:EGFR-IN-123 (compound D06) is an effective EGFR inhibitor. It exhibits inhibitory activity against several cell lines including PC-9G, A549, A431, and HCT116, with IC50 values of 0.74, 1.36, 1.20, and 2.53 μM respectively.Formula:C24H27F3N6OColor and Shape:SolidMolecular weight:472.51WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C28H30F3N7O3Purity:97.93% - 98.81%Color and Shape:SolidMolecular weight:569.58Pelitinib
CAS:Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).Formula:C24H23ClFN5O2Purity:98.37% - 99.86%Color and Shape:Off-White SolidMolecular weight:467.92Dorsomorphin
CAS:Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.Formula:C24H25N5OPurity:98% - 99.06%Color and Shape:SolidMolecular weight:399.49740 Y-P
CAS:740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.Formula:C141H222N43O39PS3Purity:98.3% - 99.87%Color and Shape:SolidMolecular weight:3270.7Anticancer agent 137
Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis.Formula:C26H27NO6Purity:98%Color and Shape:SolidMolecular weight:449.5VO-Ohpic trihydrate
CAS:VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.Formula:C12H9N2O8V·3H2O·HPurity:100%Color and Shape:SolidMolecular weight:415.2Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Formula:C18H16N2O3Purity:97.18%Color and Shape:SolidMolecular weight:308.33Ref: TM-T22450
1mg51.00€2mg73.00€5mg105.00€10mg164.00€25mg275.00€50mg378.00€100mg543.00€200mg738.00€1mL*10mM (DMSO)117.00€NSC 228155
CAS:NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Formula:C11H6N4O4SPurity:99.84%Color and Shape:SolidMolecular weight:290.25Ref: TM-T6908
2mg35.00€5mg50.00€10mg66.00€25mg125.00€50mg205.00€100mg369.00€200mg495.00€1mL*10mM (DMSO)52.00€JBJ-07-149
CAS:JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 μM when used alone, and 0.148 μM when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].Formula:C28H26N6O2SColor and Shape:SolidMolecular weight:510.61MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formula:C22H24F2N6O2Purity:100% - 100%Color and Shape:SolidMolecular weight:442.46PI3Kγ inhibitor 7
CAS:PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].Formula:C31H25N9O2Purity:98%Color and Shape:SolidMolecular weight:555.59STX-478
CAS:STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumorFormula:C16H12F5N5O2Purity:99.59%Color and Shape:SolidMolecular weight:401.29Ref: TM-T78211
1mg88.00€5mg187.00€10mg303.00€25mg612.00€50mg938.00€100mg1,568.00€1mL*10mM (DMSO)207.00€ON 146040
CAS:ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.Formula:C24H23N7O3SPurity:99.89%Color and Shape:SolidMolecular weight:489.55Ref: TM-T12310
1mg64.00€5mg145.00€10mg226.00€25mg369.00€50mg520.00€100mg695.00€200mg939.00€1mL*10mM (DMSO)158.00€(E)-AG 99
CAS:(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).Formula:C10H8N2O3Purity:99.23%Color and Shape:SolidMolecular weight:204.18
