ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Products of "ATM/ATR"
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ATR-IN-21
CAS:ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Formula:C23H27N7OPurity:98%Color and Shape:SolidMolecular weight:417.51AZD0156
CAS:AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Formula:C26H31N5O3Purity:99.03% - 99.13%Color and Shape:SolidMolecular weight:461.56Schisandrin B
CAS:Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.Formula:C23H28O6Purity:100% - 99.84%Color and Shape:SolidMolecular weight:400.46Ref: TM-T2925
1mg42.00€5mg88.00€10mg127.00€25mg230.00€50mg414.00€100mg600.00€500mg1,254.00€1mL*10mM (DMSO)94.00€Berzosertib
CAS:Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Formula:C24H25N5O3SPurity:100% - 99.7%Color and Shape:SolidMolecular weight:463.55Ref: TM-T2669
1mg35.00€5mg74.00€10mg92.00€25mg155.00€50mg225.00€100mg359.00€200mg525.00€500mg833.00€1mL*10mM (DMSO)77.00€ATR-IN-29
CAS:ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Formula:C19H22N8OPurity:98%Color and Shape:SolidMolecular weight:378.43Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFormula:C20H21N7OPurity:98.72% - 99.84%Color and Shape:SolidMolecular weight:375.43Ref: TM-T7318
1mg37.00€5mg79.00€10mg111.00€25mg216.00€50mg359.00€100mg562.00€500mg1,206.00€1mL*10mM (DMSO)87.00€PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formula:C14H16ClN3O4S2Purity:97.72%Color and Shape:SolidMolecular weight:389.88Camonsertib
CAS:Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.Formula:C21H26N6O3Purity:98.15% - 99.6%Color and Shape:SolidMolecular weight:410.47Ref: TM-T62083
1mg169.00€5mg416.00€10mg605.00€25mg944.00€50mg1,254.00€100mg1,730.00€1mL*10mM (DMSO)470.00€NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formula:C11H17N5O2Purity:98.36%Color and Shape:SolidMolecular weight:251.29ATR kinase-IN-3
CAS:ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Formula:C24H27F2N9O2Color and Shape:SolidMolecular weight:511.53Ceralasertib
CAS:Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Formula:C20H24N6O2SPurity:98% - 99.99%Color and Shape:SolidMolecular weight:412.51CP-466722
CAS:CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Formula:C17H15N7O2Purity:99.14% - 99.85%Color and Shape:SolidMolecular weight:349.35GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Formula:C16H13N4NaO3SPurity:99.70% - 99.91%Color and Shape:SolidMolecular weight:364.36azd1390
CAS:AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.Formula:C27H32FN5O2Purity:97.41% - 99.38%Color and Shape:SolidMolecular weight:477.57ATR kinase-IN-2
CAS:ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Formula:C24H29F2N9O2Color and Shape:SolidMolecular weight:513.54(S)-WSD0628
CAS:(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Formula:C23H23F2N5O2Color and Shape:SolidMolecular weight:439.458AZ20
CAS:AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.Formula:C21H24N4O3SPurity:100.00% - 98.02%Color and Shape:SolidMolecular weight:412.51KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Formula:C21H17NO3S2Purity:100% - 99.80%Color and Shape:SolidMolecular weight:395.49CGK733
CAS:CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Formula:C23H18Cl3FN4O3SPurity:98% - 99.7%Color and Shape:SolidMolecular weight:555.84Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54
