ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Products of "ATM/ATR"
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ATM Inhibitor-11
CAS:ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.Formula:C27H33FN6O2Color and Shape:SolidMolecular weight:492.59ATM Inhibitor-1
CAS:ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.Formula:C27H36N6O3Purity:98%Color and Shape:SolidMolecular weight:492.61ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Formula:C25H32N6O2Purity:98%Color and Shape:SolidMolecular weight:448.56KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Formula:C29H32N4O4S2Purity:99.10%Color and Shape:SolidMolecular weight:564.72AZ31
CAS:AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,Formula:C24H28N4O3Purity:98.01%Color and Shape:SolidMolecular weight:420.5Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Formula:C23H24O8Purity:95.84% - 99.76%Color and Shape:White SolidMolecular weight:428.43A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFormula:C27H28N6OPurity:98%Color and Shape:SolidMolecular weight:452.55Elimusertib hydrochloride(1876467-74-1 free base)
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumorFormula:C20H22ClN7OPurity:99.03%Color and Shape:SolidMolecular weight:411.89Ref: TM-T10468
1mg37.00€5mg88.00€10mg120.00€25mg235.00€50mg349.00€100mg497.00€200mg683.00€1mL*10mM (DMSO)96.00€ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFormula:C25H31N7OPurity:98%Color and Shape:SolidMolecular weight:445.56ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFormula:C26H34N6O2Purity:98%Color and Shape:SolidMolecular weight:462.59ATR-IN-24
CAS:ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].Formula:C23H26N6O2Purity:98%Color and Shape:SolidMolecular weight:418.49ART0380
CAS:ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.Formula:C18H24N6O2SPurity:100% - 99.76%Color and Shape:SolidMolecular weight:388.49Ref: TM-T85731
1mg70.00€5mg154.00€10mg210.00€25mg376.00€50mg533.00€100mg747.00€200mg1,017.00€1mL*10mM (DMSO)166.00€Gartisertib
CAS:Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.Formula:C25H29F2N9O3Purity:99.52%Color and Shape:SolidMolecular weight:541.55Ref: TM-T10407
1mg134.00€5mg321.00€10mg537.00€25mg1,074.00€50mg1,491.00€100mg2,242.00€1mL*10mM (DMSO)383.00€KU-60019
CAS:KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).Formula:C30H33N3O5SPurity:97.15% - 98.05%Color and Shape:SolidMolecular weight:547.67VE-821
CAS:VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).Formula:C18H16N4O3SPurity:99.26% - 99.97%Color and Shape:SolidMolecular weight:368.41Lartesertib
CAS:Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancerFormula:C23H21FN6O3Purity:99.9%Color and Shape:SolidMolecular weight:448.45Ref: TM-T62684
1mg130.00€2mg187.00€5mg311.00€10mg533.00€25mg1,035.00€50mg1,730.00€100mg2,680.00€1mL*10mM (DMSO)344.00€ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFormula:C20H22N6O3S2Purity:98%Color and Shape:SolidMolecular weight:458.56CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Formula:C34H46N2O6SColor and Shape:SolidMolecular weight:610.80ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formula:C30H22N4O2Purity:97.76%Color and Shape:SolidMolecular weight:470.52Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purity:98.93%Color and Shape:SolidMolecular weight:414.45
