Organometallic Ligands

N-Cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate, also known as CMC, CMCT, Morpho-CDI and CME-carbodiimide, is a reagent widely used in the detection of post-transcriptional modifications on nucleosides in RNA. RNA chemical probing is a powerful technology used to address numerous biological questions. The main application of CMC is the chemical modification of pseudouridine in RNA, in order to detect it and quantify it using analytical techniques such as primer extension or MALDI. Pseudouridine is the most abundant modification occurring in cellular RNA, and is responsible for the increased rigidity of the phosphate backbone and base stacking, impacting important RNA interactions.

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Aloe-emodin is an anthraquinone derivative that is found in the aloe plant. It has a strong stimulant laxative action. Aloe-emodin may be useful in the treatment of cancer, as it inhibits cell proliferation by inducing apoptosis. Aloe-emodin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Azilsartan medoxomil is an antihypertensive drug, which is a prodrug of the angiotensin II receptor blocker azilsartan. It is synthesized through a chemical process involving the modification of the medoxomil ester, converting it into its active form upon absorption in the gastrointestinal tract. The primary mode of action of azilsartan medoxomil involves selective antagonism of the angiotensin II type 1 (AT1) receptor. By blocking the effects of angiotensin II-a potent vasoconstrictor-azilsartan medoxomil effectively reduces vascular resistance, leading to decreased blood pressure. Azilsartan medoxomil is primarily used in the management of hypertension. By lowering elevated blood pressure, it helps reduce the risk of cardiovascular events such as strokes and myocardial infarctions. The prodrug formulation ensures efficient gastrointestinal absorption and subsequent rapid activation, making it an effective therapeutic option in the clinical setting. Given its specific receptor antagonism, azilsartan medoxomil offers targeted therapeutic intervention, contributing to improved compliance and patient outcomes in hypertensive patients.

Repaglinide is an antihyperglycemic drug that is used for the improvement of glycemic control in diabetes. This drug acts on the beta cells of the pancreas and binds to specific receptors on the beta cells known as ATP-sensitive potassium channels. As a result, this promotes insulin secretion from beta cells. Repaglinide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

CCT020312 is a small-molecule inhibitor that is a selective and potent inhibitor of the P21-activated kinase 4 (PAK4), which is sourced through synthetic organic chemistry. By inhibiting PAK4, this compound disrupts the signaling pathways that are often upregulated in various malignancies, involving proliferation, survival, and cytoskeletal reorganization. Through competitive binding at the ATP-binding site of PAK4, CCT020312 effectively suppresses kinase activity, which is crucial for downstream signaling events associated with oncogenic processes. The application of CCT020312 is significant in cancer research, where it is used to explore the role of PAK4 in tumorigenesis. By studying its effects in cell lines and animal models, researchers can analyze changes in cellular behavior including growth arrest and apoptosis. CCT020312 serves as an invaluable tool in validating PAK4 as a potential therapeutic target and understanding the molecular mechanisms underlying cancer progression. Its application extends to preclinical studies aimed at developing PAK4-targeted therapies and enhancing the efficacy of existing anti-cancer approaches.

Peptide derived from the endothelial nitric oxide synthase which synthesises nitric oxide in order to protect endothelial cells from vascular diseases, atherosclerosis and thrombosis.

D8-MMAE is a chemical conjugate product, which is composed of the highly potent cytotoxic agent monomethyl auristatin E (MMAE) linked to targeting moieties, often through a stable linker. This product is synthetic in origin, derived from auristatins, which are analogs of dolastatin 10, a natural peptide isolated from marine organisms. The mode of action of D8-MMAE involves specific binding to cellular targets, typically through an antibody-drug conjugate (ADC) mechanism, where the conjugate binds to antigens on cancer cells. Once internalized, the linker is cleaved, releasing MMAE within the cell. MMAE then binds to tubulin, inhibiting cell division by disrupting the microtubule network, leading to apoptosis. D8-MMAE is utilized primarily in cancer research and development, especially in the creation of ADCs for targeted cancer therapy. Its applications lie in delivering cytotoxic agents directly to cancer cells, thereby minimizing off-target effects and enhancing therapeutic index. This targeted approach is crucial in developing treatments for various malignancies, offering a pathway to more effective and personalized oncology therapies.

Inhibitor of COX-1 and COX-2 cyclooxygenases

Beta-2-adrenergic receptor agonist

Mardepodect is an investigative pharmaceutical compound, which is derived synthetically through a series of complex chemical reactions involving multiple steps of organic synthesis. This compound operates primarily as a selective phosphodiesterase-9 (PDE9) inhibitor, modulating intracellular signaling pathways by preventing the degradation of cyclic guanosine monophosphate (cGMP). The resulting elevated levels of cGMP lead to various downstream biological effects that can be explored for therapeutic benefits. Mardepodect is utilized in research settings to investigate potential treatments for neurological disorders and may have implications in other therapeutic areas due to its role in modulating key signaling pathways involved in cellular function and communication. Its mode of action allows scientists to explore the intricate mechanisms of disease pathogenesis and neuronal signaling, providing valuable insights into the development of new therapeutic strategies. The precise effects on the cGMP pathways could yield significant breakthroughs in understanding conditions like Alzheimer's disease, schizophrenia, and other cognitive disorders.

rac-Atomoxetine-d5 hydrochloride is an analog of the drug Atomoxetine, which is used to treat attention deficit hyperactivity disorder (ADHD). It is a ligand that binds to the α-adrenergic receptor. The racemic mixture of Atomoxetine is used as a research tool and as an analytical standard in pharmacology. The rac-Atomoxetine-d5 hydrochloride has been shown to be an inhibitor of protein interactions, such as those with the α2A-adrenergic receptor.

Farnesyl pyrophosphate synthase inhibitor; hepatic de novo lipogenesis inhibitor

N-Cyclohexylpropyl deoxynojirimycin, hydrochloride is a specific glucosidase inhibitor, which is derived from natural sources, notably microorganisms like Streptomyces species. This compound functions by competitively inhibiting alpha-glucosidases, enzymes that play a crucial role in the cleavage of glucose moieties from glycoproteins and glycolipids. Its mode of action involves binding to the active site of these enzymes, thereby preventing the normal catalytic process. The primary use of N-Cyclohexylpropyl deoxynojirimycin, hydrochloride is in biochemical research to study the pathways of glycoprotein processing and the role of glucosidases in various biological systems. It is particularly useful for dissecting the mechanisms underlying enzyme catalysis and substrate specificity in glycobiology. Furthermore, it has applications in elucidating the function of glycosidases in pathological conditions, such as lysosomal storage disorders and diabetes. By inhibiting glucosidase activity, researchers can gain insights into the modulation of cellular processes linked to carbohydrate metabolism, enhancing the understanding of disease mechanisms and potential therapeutic approaches.

FN-1501 is a synthetic bioactive compound, which is engineered through combinatorial chemistry with a specific focus on enzymatic activity. This product has been meticulously designed to emulate protease-like activity, facilitating the cleavage of peptide bonds within protein substrates. The mode of action involves the catalytic hydrolysis of peptide bonds, thereby enabling the precise dissection of protein structures for analytical studies. FN-1501 is primarily utilized in biochemical research for the mapping of protein sequences and the elucidation of protein tertiary and quaternary structures. Its application extends to proteomic studies where it assists in the digestion of proteins prior to mass spectrometry analysis. This allows for a detailed investigation of protein modifications, interactions, and mechanisms. FN-1501's stability and specificity make it an invaluable tool in structural biology research, advancing our understanding of protein function and interaction in complex biological systems.

Agonist of mechanosensitive cation channel Piezo1, which is expressed in bladder, kidney, lung, colon and skin tissues. Yoda 1 stabilizes the Piezo1 channel in an open state and reduces the threshold for mechanical activation. Yoda 1 also partially activates the Piezo1 channel in absence of mechanical stimuli.

HMG-CoA reductase inhibitor

Esomeprazole is an anti-ulcer drug that is used in the treatment of GERD and to reduce the risk of ulcers associated with NSAID’s. This drug is a proton pump inhibitor that suppresses the release of gastric acid in the stomach. Esomeprazole magnesium trihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

TVB-3664 is an analytical instrument, specifically designed for high-precision monitoring and measurement applications. It is engineered with advanced sensor technologies that provide enhanced detection capabilities, allowing for the accurate collection of data regarding various chemical and physical parameters. The source technology behind TVB-3664 involves state-of-the-art manufacturing processes, integrating robust materials with cutting-edge electronics to ensure durability and precision. The mode of action of TVB-3664 relies on its ability to autonomously calibrate and adapt to varying environmental conditions, ensuring that it delivers reliable and consistent results. This is achieved through integrated software algorithms that process raw data in real time, adjusting the sensitivity and specificity of the measurements as needed. TVB-3664 is utilized across a range of scientific disciplines, including environmental monitoring, industrial processing, and laboratory research, where precise measurement is crucial. Its applications extend into fields such as chemistry, biology, and physics, and it serves as an essential tool in both applied and theoretical research settings. Scientists appreciate the device’s versatility, robustness, and high accuracy, making it a preferred choice for complex analyses and long-term experiments.

5-Phenacyloxy-2H-isoquinolin-1-one is a synthetic chemical compound, which is primarily utilized as a biochemical inhibitor. This compound is derived from isoquinolinone sources and is distinguished by its phenacyloxy moiety linking it to the isoquinolinone core structure. Its mechanism of action involves selectively inhibiting specific biological pathways, a characteristic that makes it a valuable tool in the study of enzyme regulation and signal transduction processes. By interfering with these pathways, 5-Phenacyloxy-2H-isoquinolin-1-one provides insights into cellular functions and the biochemical landscape. In research settings, this compound is extensively applied in the exploration of therapeutic targets, particularly within the realms of cancer research and neurobiology. Scientists harness its ability to disrupt specific enzymatic activities to elucidate molecular mechanisms and identify potential intervention points for drug development. The versatility and specificity of 5-Phenacyloxy-2H-isoquinolin-1-one render it an indispensable reagent in the biochemical toolbox, facilitating advancements in molecular biology and pharmacology.